Search Results - "Van Helvoort Lengert, André"

Comprehensive Molecular Landscape of Cetuximab Resistance in Head and Neck Cancer Cell Lines by Gomes, Izabela N F, da Silva-Oliveira, Renato J, da Silva, Luciane Sussuchi, Martinho, Olga, Evangelista, Adriane F, van Helvoort Lengert, André, Leal, Letícia Ferro, Silva, Viviane Aline Oliveira, Dos Santos, Stéphanie Piancenti, Nascimento, Flávia Caroline, Lopes Carvalho, André, Reis, Rui Manuel

“…Cetuximab is the sole anti-EGFR monoclonal antibody that is FDA approved to treat head and neck squamous cell carcinoma (HNSCC). However, no predictive…”
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Temozolomide resistance mechanisms: unveiling the role of translesion DNA polymerase kappa in glioblastoma spheroids in vitro by Ribeiro, Diego Luis, Latancia, Marcela Teatin, de Souza, Izadora, Ariwoola, Abu-Bakr Adetayo, Mendes, Davi, Rocha, Clarissa Ribeiro Reily, Lengert, André Van Helvoort, Menck, Carlos Frederico Martins

“…Temozolomide (TMZ) is the leading therapeutic agent for combating Glioblastoma Multiforme (GBM). Nonetheless, the persistence of chemotherapy-resistant GBM…”
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Absolute telomere length in peripheral blood lymphocytes of workers exposed to construction environment by Rohr, Paula, Campanelli dos Santos, Isabela, van Helvoort Lengert, André, Alves de Lima, Marcos, Manuel Reis, Rui, Barbosa, Fernando, Cesar Santejo Silveira, Henrique

“…Construction environment is composed of various substances classified as carcinogens. Thus, workers exposed in this environment can be susceptible to genomic…”
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Cisplatin‑resistant germ cell tumor models: An exploration of the epithelial‑mesenchymal transition regulator SLUG by Cardoso, Ingridy Izabella Vieira, Rosa, Marcela Nunes, Moreno, Daniel Antunes, Tufi, Letícia Maria Barbosa, Ramos, Lorrayne Pereira, Pereira, Larissa Alessandra Bourdeth, Silva, Lenilson, Galvão, Janaina Mello Soares, Tosi, Isabela Cristiane, Lengert, André Van Helvoort, Da Cruz, Marcelo Cavalcanti, Teixeira, Silvia Aparecida, Reis, Rui Manuel, Lopes, Luiz Fernando, Pinto, Mariana Tomazini

“…Germ cell tumors (GCTs) constitute diverse neoplasms arising in the gonads or extragonadal locations. Testicular GCTs (TGCTs) are the predominant solid tumors…”
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High Expression of HULC Is Associated with Poor Prognosis in Osteosarcoma Patients by Uzan, Vanessa Regina Maciel, Lengert, André van Helvoort, Boldrini, Érica, Penna, Valter, Scapulatempo-Neto, Cristovam, Scrideli, Carlos Alberto, Filho, Alberto Paiva de Moraes, Cavalcante, Carlos Eduardo Bezerra, de Oliveira, Cleyton Zanardo, Lopes, Luiz Fernando, Vidal, Daniel Onofre

“…Osteosarcoma (OS) is the most common primary bone cancer in childhood. OS is an aggressive disease, and metastatic patients evolve with very poor clinical…”
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Potential New Therapeutic Approaches for Cisplatin-Resistant Testicular Germ Cell Tumors by Lengert, André van Helvoort, Pereira, Leticia do Nascimento Braga, Cabral, Eduardo Ramos Martins, Gomes, Izabela Natalia Faria, Jesus, Lais Machado de, Gonçalves, Maria Fernanda Santiago, Rocha, Aline Oliveira da, Tassinari, Tiago Alexandre, Silva, Luciane Sussuchi da, Laus, Ana Carolina, Vidal, Daniel Onofre, Pinto, Mariana Tomazini, Reis, Rui Manuel, Lopes, Luiz Fernando

“…BACKGROUNDTesticular germ cell tumors (TGCTs), a group of heterogeneous neoplasms, are the most frequent tumors of teenagers and young men, with the incidence…”
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DNA methylation patterns suggest the involvement of DNMT3B and TET1 in osteosarcoma development by Pires, Sara Ferreira, de Barros, Juliana Sobral, da Costa, Silvia Souza, de Oliveira Scliar, Marília, Van Helvoort Lengert, André, Boldrini, Érica, da Silva, Sandra Regina Morini, Tasic, Ljubica, Vidal, Daniel Onofre, Krepischi, Ana Cristina Victorino, Maschietto, Mariana

“…DNA methylation may be involved in the development of osteosarcomas. Osteosarcomas commonly arise during the bone growth and remodeling in puberty, making it…”
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Detection of Alterations in the Gut Microbiota and Intestinal Permeability in Patients With Hashimoto Thyroiditis by Cayres, Leonardo César de Freitas, de Salis, Larissa Vedovato Vilela, Rodrigues, Guilherme Siqueira Pardo, Lengert, André van Helvoort, Biondi, Ana Paula Custódio, Sargentini, Larissa Donadel Barreto, Brisotti, João Luiz, Gomes, Eleni, de Oliveira, Gislane Lelis Vilela

“…Hashimoto thyroiditis (HT) is the most common autoimmune disease worldwide, characterized by chronic inflammation and circulating autoantibodies against…”
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MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression by Causin, Rhafaela Lima, Van Helvoort Lengert, André, Gomes, Izabela Natalia Faria, De Freitas, Ana Julia Aguiar, Rosa, Marcela Nunes, Dos Reis, Ricardo, Reis, Rui Manuel, Marques, Márcia Maria Chiquitelli

“…MicroRNAs (miRNAs or miRs) play essential roles in the initiation and progression of human tumors, including cervical cancer. However, the mechanisms…”
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Analysis of the Mutational Landscape of Osteosarcomas Identifies Genes Related to Metastasis and Prognosis and Disrupted Biological Pathways of Immune Response and Bone Development by Pires, Sara Ferreira, Barros, Juliana Sobral de, Costa, Silvia Souza da, Carmo, Gabriel Bandeira do, Scliar, Marília de Oliveira, Lengert, André van Helvoort, Boldrini, Érica, Silva, Sandra Regini Morini da, Vidal, Daniel Onofre, Maschietto, Mariana, Krepischi, Ana Cristina Victorino

“…Osteosarcoma (OS) is the most prevalent type of bone tumor, but slow progress has been achieved in disentangling the full set of genomic events involved in its…”
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Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines by da Silva-Oliveira, Renato José, Gomes, Izabela Natalia Faria, da Silva, Luciane Sussuchi, Lengert, André van Helvoort, Laus, Ana Carolina, Melendez, Matias Eliseo, Munari, Carla Carolina, Cury, Fernanda de Paula, Longato, Giovanna Barbarini, Reis, Rui Manuel

“…Background: EGFR mutations are present in approximately 15−50% of non-small cell lung cancer (NSCLC), which are predictive of anti-EGFR therapies. At variance,…”
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Comprehensive microRNA expression analysis of pediatric gonadal germ cell tumors: unveiling novel biomarkers and signatures by Santarosa Vieira, Ana Glenda, Silva, Luciane Sussuchi, Albino da Silva, Eduardo Caetano, Laus, Ana Carolina, Faria, Thaíssa Maria Veiga, Helvoort Lengert, André, Martins, Gisele Eiras, Oliveira, Marco Antônio, Reis, Rui Manuel, Lopes, Luiz Fernando, Pinto, Mariana Tomazini

“…microRNAs (miRNAs) are small endogenous noncoding RNAs, and alterations in their expression may contribute to oncogenesis. Discovering a unique miRNA pattern…”
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The Brazilian TP53 mutation (R337H) and sarcomas by Volc, Sahlua Miguel, Ramos, Cíntia Regina Niederauer, Galvão, Henrique de Campos Reis, Felicio, Paula Silva, Coelho, Aline Silva, Berardineli, Gustavo Noriz, Campacci, Natalia, Sabato, Cristina da Silva, Abrahao-Machado, Lucas Faria, Santana, Iara Viana Vidigal, Campanella, Nathalia, Lengert, André van Helvoort, Vidal, Daniel Onofre, Reis, Rui Manuel, Dantas, Caio F, Coelho, Robson C, Boldrini, Erica, Serrano, Sergio Vicente, Palmero, Edenir Inêz

“…Sarcomas represent less than 1% of all solid neoplasms in adults and over 20% in children. Their etiology is unclear, but genetic susceptibility plays an…”
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The Antitumoral/Antimetastatic Action of the Flavonoid Brachydin A in Metastatic Prostate Tumor Spheroids In Vitro Is Mediated by (Parthanatos) PARP-Related Cell Death by Ribeiro, Diego Luis, Tuttis, Katiuska, Oliveira, Larissa Cristina Bastos de, Serpeloni, Juliana Mara, Gomes, Izabela Natalia Faria, Lengert, André van Helvoort, Rocha, Cláudia Quintino da, Reis, Rui Manuel, Cólus, Ilce Mara de Syllos, Antunes, Lusânia Maria Greggi

“…Metastatic prostate cancer (mPCa) is resistant to several chemotherapeutic agents. Brachydin A (BrA), a glycosylated flavonoid extracted from , displays a…”
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Lipidomics by Nuclear Magnetic Resonance Spectroscopy and Liquid Chromatography-High-Resolution Mass Spectrometry in Osteosarcoma: A Pilot Study by Pontes, João Guilherme de Moraes, Jadranin, Milka, Assalin, Márcia Regina, Quintero Escobar, Melissa, Stanisic, Danijela, Costa, Tássia Brena Barroso Carneiro, van Helvoort Lengert, André, Boldrini, Érica, Morini da Silva, Sandra Regina, Vidal, Daniel Onofre, Liu, Leticia Huan Bacellar, Maschietto, Mariana, Tasic, Ljubica

“…Cancer is a complex disease that can also affect the younger population; however, it is responsible for a relatively high mortality rate of children and youth,…”
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Screening and characterization of BRCA2 c.156_157insAlu in Brazil: Results from 1380 individuals from the South and Southeast by Felicio, Paula Silva, Alemar, Barbara, Coelho, Aline Silva, Berardinelli, Gustavo Noriz, Melendez, Matias Eliseo, Lengert, André Van Helvoort, Miche lli, Rodrigo Depieri, Reis, Rui M., Fernandes, Gabriela Carvalho, Ewald, Ingrid Petroni, Bittar, Camila Matzenbacher, Netto, Cristina Brinckmann Oliveira, Artigalas, Osvaldo, Peixoto, Ana, Pinheiro, Manuela, Teixeira, Manuel R., Vargas, Fernando Regla, dos Santos, Anna Cláudia Evangelista, Moreira, Miguel Angelo Martins, Ashton-Prolla, Patricia, Palmero, Edenir Inêz

“…•In our cohort, the frequency of the Portuguese BRCA2 founder mutation (c.156_157insAlu) was 0.65%.•The most frequent ancestry proportions of the mutation…”
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Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population by de Oliveira, Andréia Ávila Soares, Souza, Marilesia Ferreira de, Lengert, André van Helvoort, de Oliveira, Marcelo Tempesta, Camargo, Rossana Batista de Oliveira Godoy, Braga, Gilberto Úbida Leite, Cólus, Ilce Mara de Syllos, Barbosa Junior, Fernando, Barcelos, Gustavo Rafael Mazzaron

“…This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in…”
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MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients by Martinelli, Camila Maria da Silva, Lengert, André van Helvoort, Cárcano, Flavio Mavignier, Silva, Eduardo Caetano Albino, Brait, Mariana, Lopes, Luiz Fernando, Vidal, Daniel Onofre

“…Testicular germ cell tumors (TGCT) represent the second main cause of cancer-related death in young men. Despite high cure rates, refractory disease results in…”
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Genomic instability evaluation by BMCyt and telomere length in Brazilian family farmers exposed to pesticides by dos Santos, Isabela Campanelli, da Silva, Jefferson Tenesse, Rohr, Paula, Lengert, André van Helvoort, de Lima, Marcos Alves, Kahl, Vivian Francilia Silva, da Silva, Juliana, Reis, Rui Manuel, Silveira, Henrique César Santejo

“…Brazil is one of the largest consumers of pesticides in the world. This high consumption has resulted in higher potential health risk to agricultural farm…”
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Polymorphisms in glutathione-related genes modify mercury concentrations and antioxidant status in subjects environmentally exposed to methylmercury by Barcelos, Gustavo Rafael Mazzaron, Grotto, Denise, de Marco, Kátia Cristina, Valentini, Juliana, Lengert, André van Helvoort, Oliveira, Andréia Ávila Soares de, Garcia, Solange Cristina, Braga, Gilberto Úbida Leite, Schläwicke Engström, Karin, Cólus, Ilce Mara de Syllos, Broberg, Karin, Barbosa, Fernando

“…Methylmercury (MeHg) toxicity may vary widely despite similar levels of exposure. This is hypothetically related to genetic differences in enzymes metabolizing…”
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