Search Results - "Van Hauwermeiren, Daan"

In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed process understanding by Verstraeten, Maxim, Van Hauwermeiren, Daan, Lee, Kai, Turnbull, Neil, Wilsdon, David, am Ende, Mary, Doshi, Pankaj, Vervaet, Chris, Brouckaert, Davinia, Mortier, Séverine T.F.C., Nopens, Ingmar, Beer, Thomas De

“…[Display omitted] Twin-screw wet granulation is gaining increasing interest within the pharmaceutical industry for the continuous manufacturing of solid oral…”
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Predicting Pharmaceutical Particle Size Distributions Using Kernel Mean Embedding by Van Hauwermeiren, Daan, Stock, Michiel, De Beer, Thomas, Nopens, Ingmar

“…In the pharmaceutical industry, the transition to continuous manufacturing of solid dosage forms is adopted by more and more companies. For these continuous…”
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Improvement of a 1D Population Balance Model for Twin-Screw Wet Granulation by Using Identifiability Analysis by Barrera Jiménez, Ana Alejandra, Van Hauwermeiren, Daan, Peeters, Michiel, De Beer, Thomas, Nopens, Ingmar

“…Recently, the pharmaceutical industry has undergone changes in the production of solid oral dosages from traditional inefficient and expensive batch production…”
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Application of iterative robust model‐based optimal experimental design for the calibration of biocatalytic models by Van Daele, Timothy, Gernaey, Krist V., Ringborg, Rolf H., Börner, Tim, Heintz, Søren, Van Hauwermeiren, Daan, Grey, Carl, Krühne, Ulrich, Adlercreutz, Patrick, Nopens, Ingmar

“…The aim of model calibration is to estimate unique parameter values from available experimental data, here applied to a biocatalytic process. The traditional…”
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Analysis of the Influence of Process and Formulation Properties on the Drying Behavior of Pharmaceutical Granules in a Semi-Continuous Fluid Bed Drying System by Vandeputte, Tuur, Ghijs, Michael, Peeters, Michiel, De Man, Alexander, Van Hauwermeiren, Daan, Dos Santos Schultz, Eduardo, Vigh, Tamas, Stauffer, Fanny, Nopens, Ingmar, De Beer, Thomas

“…In the last decade, twin-screw wet granulation became an essential technology for continuous pharmaceutical tablet production. Consequently, interest in…”
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T-shaped partial least squares for high-dosed new active pharmaceutical ingredients in continuous twin-screw wet granulation: Granule size prediction with limited material information by Matsunami, Kensaku, Meyer, Jonathan, Rowland, Martin, Dawson, Neil, De Beer, Thomas, Van Hauwermeiren, Daan

“…This work presents a granule size prediction approach applicable to diverse formulations containing new active pharmaceutical ingredients (APIs) in continuous…”
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A framework for the in silico assessment of the robustness of an MPC in a CDC line in function of process variability by Waeytens, Ruben, Van Hauwermeiren, Daan, Grymonpré, Wouter, Nopens, Ingmar, De Beer, Thomas

“…The shift from batch manufacturing towards continuous manufacturing for the production of oral solid dosages requires the development and implementation of…”
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Effect of process parameters and formulation properties on the lead-lag between in-line NIR tablet press feed frame and off-line NIR tablet measurements by Peeters, Michiel, Peeters, Elisabeth, Van Hauwermeiren, Daan, Cogoni, Giuseppe, De Beer, Thomas

“…[Display omitted] The use of in-line near-infrared (NIR) measurements for tablet potency monitoring and diversion was studied. First, the optimal sample size…”
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Determination and understanding of lead-lag between in-line NIR tablet press feed frame and off-line NIR tablet measurements by Peeters, Michiel, Peeters, Elisabeth, Van Hauwermeiren, Daan, Cogoni, Giuseppe, Liu, Yang, De Beer, Thomas

“…[Display omitted] The influence of different tableting process parameters on lead-lag was studied by collecting in-line near-infrared (NIR) spectra in the…”
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An extended 3-compartment model for describing step change experiments in pharmaceutical twin-screw feeders at different refill regimes by Waeytens, Ruben, De Souter, Lisa, Grymonpré, Wouter, Van Hauwermeiren, Daan, Nopens, Ingmar, De Beer, Thomas

“…Residence time distributions (RTDs) are a valuable tool for product tracking in the unit operations of a continuous line for manufacturing pharmaceutical oral…”
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Mechanistic modeling of semicontinuous fluidized bed drying of pharmaceutical granules by incorporating single particle and bulk drying kinetics by Vandeputte, Tuur, Ghijs, Michael, Van Hauwermeiren, Daan, Dos Santos Schultz, Eduardo, Schäfer, Elisabeth, Stauffer, Fanny, De Beer, Thomas, Nopens, Ingmar

“…In this work, a mechanistic fluidized bed drying model computing the granule moisture content in function of granule size, drying time, process settings and…”
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A multivariate formulation and process development platform for direct compression by Dhondt, Jens, Bertels, Johny, Kumar, Ashish, Van Hauwermeiren, Daan, Ryckaert, Alexander, Van Snick, Bernd, Klingeleers, Didier, Vervaet, Chris, De Beer, Thomas

“…[Display omitted] The efficient development of robust tableting processes is challenging due to the lack of mechanistic understanding on the impact of raw…”
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Development of a tablet press feed frame lead lag determination model using in-line and off-line NIR measurements by Van Hauwermeiren, Daan, Peeters, Michiel, Peeters, Elisabeth, Cogoni, Giuseppi, Yang, Liu A., De Beer, Thomas

“…[Display omitted] •Lead-lag behaviour can be modeled using a simple, yet effective tanks-in-series model.•Markov Chain Monte Carlo techniques are a powerful…”
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Exploring the effect of raw material properties on continuous twin-screw wet granulation manufacturability by Peeters, Michiel, Barrera Jiménez, Ana Alejandra, Matsunami, Kensaku, Van Hauwermeiren, Daan, Stauffer, Fanny, Arnfast, Lærke, Vigh, Tamas, Nopens, Ingmar, De Beer, Thomas

“…[Display omitted] Twin-screw wet granulation (TSWG) stands out as a promising continuous alternative to conventional batch fluid bed- and high shear wet…”
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Model-based NIR spectroscopy implementation for in-line assay monitoring during a pharmaceutical suspension manufacturing process by Verstraeten, Maxim, Van Hauwermeiren, Daan, Hellings, Mario, Hermans, Eline, Geens, Jeroen, Vervaet, Chris, Nopens, Ingmar, De Beer, Thomas

“…[Display omitted] The implementation of Process Analytical Technology (PAT) instruments is generally achieved stochastically. Sub-optimal PAT locations could…”
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Model development and calibration of two-dimensional population balance model for twin-screw wet granulation based on particle size distribution and porosity by Barrera Jiménez, Ana Alejandra, Matsunami, Kensaku, Ghijs, Michael, Van Hauwermeiren, Daan, Peeters, Michiel, Stauffer, Fanny, De Beer, Thomas, Nopens, Ingmar

“…Population balance models (PBMs) have been widely studied for the simulation of continuous twin-screw wet granulation. Due to the limited data availability and…”
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Heat Transfer Evaluation During Twin-Screw Wet Granulation in View of Detailed Process Understanding by Stauffer, Fanny, Ryckaert, Alexander, Van Hauwermeiren, Daan, Funke, Adrian, Djuric, Dejan, Nopens, Ingmar, De Beer, Thomas

“…During the last decade, the pharmaceutical industry has shown a growing interest in continuous twin-screw granulation (TSG). Despite flourishing literature on…”
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Validation of model-based design of experiments for continuous wet granulation and drying by Matsunami, Kensaku, Vandeputte, Tuur, Barrera Jiménez, Ana Alejandra, Peeters, Michiel, Ghijs, Michael, Van Hauwermeiren, Daan, Stauffer, Fanny, dos Santos Schultz, Eduardo, Nopens, Ingmar, De Beer, Thomas

“…This paper presents an application case of model-based design of experiments for the continuous twin-screw wet granulation and fluid-bed drying sequence. The…”
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Partial least squares regression to calculate population balance model parameters from material properties in continuous twin-screw wet granulation by Barrera Jiménez, Ana Alejandra, Matsunami, Kensaku, Van Hauwermeiren, Daan, Peeters, Michiel, Stauffer, Fanny, dos Santos Schultz, Eduardo, Kumar, Ashish, De Beer, Thomas, Nopens, Ingmar

“…In the pharmaceutical industry, twin-screw wet granulation has become a realistic option for the continuous manufacturing of solid drug products. Towards the…”
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Linking material properties to 1D-PBM parameters towards a generic model for twin-screw wet granulation by Barrera Jiménez, Ana Alejandra, Matsunami, Kensaku, Van Hauwermeiren, Daan, Peeters, Michiel, Stauffer, Fanny, dos Santos Schultz, Eduardo, Kumar, Ashish, De Beer, Thomas, Nopens, Ingmar

“…Population balance models (PBM) have been widely used to model the twin-screw wet granulation (TSWG) in the continuous manufacturing of solid dosage forms…”
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