Search Results - "Van Haitsma, Jared"

A Highly Enantioselective Allylic Amination Reaction Using a Commercially Available Chiral Rhodium Catalyst: Resolution of Racemic Allylic Carbonates by Vrieze, Derek C, Hoge, Garrett S, Hoerter, Perrine Z, Van Haitsma, Jared T, Samas, Brian M

“…A novel method for the kinetic resolution of unsymmetrical acyclic allylic carbonates and the concurrent synthesis of enantioenriched secondary amines using a…”
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Development of a Cost-Efficient Process Toward a Key Synthetic Intermediate of the EZH2 Inhibitor PF-06821497 by Ashcroft, Christopher P., Berne, Alexander M., Blasberg, Florian, Catlin, Kelly, Collins, Michael R., Critcher, Doug J., Desrosiers, Jean-Nicolas, Goetz, Adam, Hayward, Cheryl, Jones, Ricky A., Karmilowicz, Michael J., Keene, Nandell, Martinez, Carlos A., Monfette, Sebastien, Pattavina, Sebastian David, Perfect, Hahdi H., Ragan, John A., Rauschenberger, Blake, Sach, Neal W., Scotney, Gemma, Sutton, Scott C., Talicska, Courtney, Twiddle, Steven J.R., Haitsma, Jared Van, Wisdom, Richard

“…A cost-efficient approach for the synthesis of a key intermediate of the EZH2 inhibitor PF-06821497 was identified after performing process chemistry…”
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Pinnick Oxidation on Scale: Process Development of a BDK Inhibitor by Arcari, Joel T., Buckley, Catherine, Buzon, Leanne M., Dan, Yongbo, Houck, Timothy, Jin, Zuxi, Li, Chao, Li, Peifang, Liu, Kai, Liu, Yiyang, Magano, Javier, Martinez-Alsina, Luis A., Nguyen, Bao, Pearson, Robert, Piper, Jared L., Ragan, John A., Reese, Matthew R., Tian, Wanli, Van Haitsma, Jared, Vetelino, Michael G., Zhang, Yuan

“…The development of a safe and scalable Pinnick oxidation of an aldehyde to a carboxylic acid in the late-stage synthesis of a BDK inhibitor candidate,…”
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Early Process Development of PF-07054894, a Squaramide-Based Antagonist of C–C Chemokine Receptor Type 6 (CCR6) by Chinigo, Gary M., McInturff, Emma L., Bagley, Scott W., Barnhart, Richard W., Blakemore, David C., Han, Lu, Lee, Taegyo, Magano, Javier, McWilliams, J. Christopher, Monfette, Sebastien, Mousseau, James J., Pan, Senliang, Pedro, Dylan, Perfect, Hahdi H., Raggon, Jeffrey W., Rose, Peter R., Sagal, John, Trujillo, John I., Van Haitsma, Jared, Vetelino, Michael G., Yang, Xiaojing Helen

“…The original synthesis of a CCR6 antagonist and subsequent enablement for kilogram manufacture is presented. Highlighted improvements made in the preparation…”
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Overcoming the Challenges of Making a Single Enantiomer N‑1 Substituted Tetrazole Prodrug Using a Tin-Mediated Alkylation and Enzymatic Resolution by Akin, Anne, Barilla, Mark T, Brandt, Thomas A, Brennan, John, Henegar, Kevin E, Hoagland, Steve, Kumar, Rajesh, Magano, Javier, McInturff, Emma L, Nematalla, Asaad, Piotrowski, David W, Van Haitsma, Jared, Wei, Liuqing, Xiao, Jun, Yu, Shu

“…The synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor 3 is described. This complex structure contains a tetrazole modified by a…”
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