Search Results - "Van Haeften, T W"

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms by Schäfer, S. A, Tschritter, O, Machicao, F, Thamer, C, Stefan, N, Gallwitz, B, Holst, J. J, Dekker, J. M, t'Hart, L. M, Nijpels, G, van Haeften, T. W, Häring, H. U, Fritsche, A

“…Aims/hypothesis Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes and reduced insulin secretion. The…”
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Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps by Groenewoud, M. J, Dekker, J. M, Fritsche, A, Reiling, E, Nijpels, G, Heine, R. J, Maassen, J. A, Machicao, F, Schäfer, S. A, Häring, H. U, t Hart, L. M, van Haeften, T. W

“…Aims/hypothesis Genome-wide association studies have recently identified novel type 2 diabetes susceptibility gene regions. We assessed the effects of six of…”
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Clustering of additional autoimmunity behaves differently in Hashimoto's patients compared with Graves' patients by Wiebolt, J, Achterbergh, R, den Boer, A, van der Leij, S, Marsch, E, Suelmann, B, de Vries, R, van Haeften, T W

“…ObjectiveIt is unclear whether Hashimoto's thyroiditis and Graves' disease (often referred to as autoimmune thyroid disease, AITD) cluster to the same extent…”
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Sex hormone-binding globulin concentrations before conception as a predictor for gestational diabetes in women with polycystic ovary syndrome by Veltman-Verhulst, S.M., van Haeften, T.W., Eijkemans, M.J.C., de Valk, H.W., Fauser, B.C.J.M., Goverde, A.J.

“…BACKGROUND Low plasma sex hormone-binding globulin (SHBG) concentrations during pregnancy have been associated with the risk of developing gestational diabetes…”
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Insulin-like growth factors and pancreas beta cells by Van Haeften, T. W., Twickler, Th. B.

“…Insulin‐like growth factors (IGFs) have been implicated in normal growth, and especially foetal pancreas beta‐cell development. As low birth weight has been…”
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Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort by VAN VLIET-OSTAPTCHOUK, J. V, SHIRI-SVERDLOV, R, ZHERNAKOVA, A, STRENGMAN, E, VAN HAEFTEN, T. W, HOFKER, M. H, WIJMENGA, C

“…A strong association between susceptibility to type 2 diabetes and common variants of transcription factor 7-like 2 (TCF7L2), encoding an enteroendocrine…”
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Defining the genetic contribution of type 2 diabetes mellitus by van Tilburg, Jonathan, van Haeften, Timon W, Pearson, Peter, Wijmenga, Cisca

“…Type 2 diabetes mellitus is a common multifactorial genetic syndrome, which is determined by several different genes and environmental factors. It now affects…”
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Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity by Wolfs, M G M, Gruben, N, Rensen, S S, Verdam, F J, Greve, J W, Driessen, A, Wijmenga, C, Buurman, W A, Franke, L, Scheja, L, Koonen, D P Y, Shiri-Sverdlov, R, van Haeften, T W, Hofker, M H, Fu, J

“…Objectives: Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated disease, and in obesity adipokines are believed to be involved in the…”
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Does physical training increase insulin sensitivity in chronic heart failure patients? by Sabelis, L W E, Senden, P J, Te Boekhorst, B C M, Hulzebos, H J, Van De Wiel, A, Van Haeften, T W, Zonderland, M L, Mosterd, W L

“…To determine the effect of training on insulin sensitivity (IS) and how this relates to peak V(.)O(2) (peak oxygen uptake) in CHF (chronic heart failure), 77…”
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Insulin secretion in normal glucose-tolerant relatives of type 2 diabetic subjects. Assessments using hyperglycemic glucose clamps and oral glucose tolerance tests by VAN HAEFTEN, T. W, DUBBELDAM, S, ZONDERLAND, M. L, ERKELENS, D. W

“…Insulin secretion in normal glucose-tolerant relatives of type 2 diabetic subjects. Assessments using hyperglycemic glucose clamps and oral glucose tolerance…”
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Waist circumference and metabolic risk factors have separate and additive effects on the risk of future Type 2 diabetes in patients with vascular diseases. A cohort study by Wassink, A. M. J., van der Graaf, Y., van Haeften, T. W., Spiering, W., Soedamah-Muthu, S. S., Visseren, F. L. J.

“…Diabet. Med. 28, 932–940 (2011) Aims  To assess the effect of various measures of adiposity and of metabolic risk factors, both separately and in combination,…”
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Diabetic environment in utero and predisposition to type 2 diabetes by van Haeften, TW, Twickler, TB

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Genome-wide screen in obese pedigrees with type 2 diabetes mellitus from a defined Dutch population by Van Tilburg, J. H., Sandkuijl, L. A., Franke, L., Strengman, E., Pearson, P. L., Van Haeften, T. W., Wijmenga, C.

“…A genome scan was performed in obese type 2 diabetes mellitus pedigrees to identify susceptibility loci involved in obesity‐driven type 2 diabetes mellitus. We…”
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Clinical characteristics of type 1 diabetic patients with and without severe hypoglycemia by TER BRAAK, Edith W. M. T, APPELMAN, Alexander M. M. F, VAN DE LAAK, Mariëlle F, STOLK, Ronald P, VAN HAEFTEN, Timon W, ERKELENS, D. Willem

“…Clinical characteristics of type 1 diabetic patients with and without severe hypoglycemia. E W ter Braak , A M Appelman , M van de Laak , R P Stolk , T W van…”
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Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus by HART, L. M, DEKKER, J. M, VAN HAEFTEN, T. W, RUIGE, J. B, STEHOUWER, C. D. A, ERKELENS, D. W, HEINE, R. J, MAASSEN, J. A

“…The sulphonylurea receptor is a subunit of the ATP-sensitive potassium channel in the pancreatic beta cell. Mutations at nt -3 of the splice acceptor site of…”
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A Genome-Wide Scan in Type 2 Diabetes Mellitus Provides Independent Replication of a Susceptibility Locus on 18p11 and Suggests the Existence of Novel Loci on 2q12 and 19q13 by van Tilburg, J. H. O., Sandkuijl, L. A., Strengman, E., van Someren, H., Rigters-Aris, C. A. E., Pearson, P. L., van Haeften, T. W, Wijmenga, C.

“…A genome-wide scan was performed, using nonparametric linkage analyses, to find susceptibility loci for type 2 diabetes mellitus in the Dutch population. We…”
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Insulin-like growth factor-I genotype and birthweight by Twickler, Th B, de Sain-van der Velden, MGM, van Doorn, J, van Haeften, TW

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Clinical significance of insulin antibodies in insulin-treated diabetic patients by Van Haeften, T W

“…Clinical significance of insulin antibodies in insulin-treated diabetic patients. T W Van Haeften Department of Endocrinology, Free University Hospital,…”
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Lower β-cell secretion in physically active first-degree relatives of type 2 diabetes patients by Zonderland, M.L., Dubbeldam, S., Erkelens, D.W., van Haeften, T.W.

“…Regular physical activity may prevent or postpone type 2 diabetes, and is thought to be related to an increase of insulin sensitivity. We studied whether…”
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Relative contributions of β-cell function and tissue insulin sensitivity to fasting and postglucose-load glycemia by van Haeften, T.W., Pimenta, W., Mitrakou, A., Korytkowski, M., Jenssen, T., Yki-Jarvinen, H., Gerich, J.E.

“…We performed hyperglycemic clamps in 283 nondiabetic Caucasians and, with multiple linear regression, determined the contribution of β-cell function and tissue…”
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