Search Results - "Van Haastert, Peter JM"

Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum by Veltman, Douwe M, Keizer-Gunnik, Ineke, Van Haastert, Peter J.M

“…Chemotaxis is the ability of cells to move in the direction of an external gradient of signaling molecules. Cells are guided by actin-filled protrusions in the…”
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The ordered extension of pseudopodia by amoeboid cells in the absence of external cues by Bosgraaf, Leonard, Van Haastert, Peter J M

“…Eukaryotic cells extend pseudopodia for movement. In the absence of external cues, cells move in random directions, but with a strong element of persistence…”
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Ras activation and symmetry breaking during Dictyostelium chemotaxis by Kortholt, Arjan, Keizer-Gunnink, Ineke, Kataria, Rama, Van Haastert, Peter J M

“…Central to chemotaxis is the molecular mechanism by which a shallow spatial gradient of chemoattractant induces symmetry breaking of activated signaling…”
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Chemotaxis: signalling the way forward by Van Haastert, Peter J. M, Devreotes, Peter N

“…During random locomotion, human neutrophils and Dictyostelium discoideum amoebae repeatedly extend and retract cytoplasmic processes. During directed cell…”
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Chemotaxis: insights from the extending pseudopod by Van Haastert, Peter J.M

“…Chemotaxis is one of the most fascinating processes in cell biology. Shallow gradients of chemoattractant direct the movement of cells, and an intricate…”
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Biased Random Walk by Stochastic Fluctuations of Chemoattractant-Receptor Interactions at the Lower Limit of Detection by van Haastert, Peter J.M., Postma, Marten

“…Binding of ligand to its receptor is a stochastic process that exhibits fluctuations in time and space. In chemotaxis, this leads to a noisy input signal…”
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A Stochastic Model for Chemotaxis Based on the Ordered Extension of Pseudopods by Van Haastert, Peter J.M.

“…Many amoeboid cells move by extending pseudopods. Here I present a new stochastic model for chemotaxis that is based on pseudopod extensions by Dictyostelium…”
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Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis by van Haastert, Peter J.M, Keizer-Gunnink, Ineke, Kortholt, Arjan

“…Chemotaxis toward different cyclic adenosine monophosphate (cAMP) concentrations was tested in Dictyostelium discoideum cell lines with deletion of specific…”
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Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis by Kataria, Rama, Xu, Xuehua, Fusetti, Fabrizia, Keizer-Gunnink, Ineke, Jin, Tian, van Haastert, Peter J. M., Kortholt, Arjan

“…Heterotrimeric G proteins couple external signals to the activation of intracellular signal transduction pathways. Agonist-stimulated guanine nucleotide…”
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Highlighting the role of Ras and Rap during Dictyostelium chemotaxis by Kortholt, Arjan, van Haastert, Peter J.M.

“…Chemotaxis, the directional movement towards a chemical compound, is an essential property of many cells and has been linked to the development and progression…”
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Symmetry Breaking during Cell Movement in the Context of Excitability, Kinetic Fine-Tuning and Memory of Pseudopod Formation by van Haastert, Peter J M

“…The path of moving eukaryotic cells depends on the kinetics and direction of extending pseudopods. Amoeboid cells constantly change their shape with pseudopods…”
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Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling by Sato, Masayuki J, Kuwayama, Hidekazu, van Egmond, Wouter N, Takayama, Airi L.K, Takagi, Hiroaki, van Haastert, Peter J.M, Yanagida, Toshio, Ueda, Masahiro

“…Switching between attractive and repulsive migration in cell movement in response to extracellular guidance cues has been found in various cell types and is an…”
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A model for a correlated random walk based on the ordered extension of pseudopodia by Van Haastert, Peter J M

“…Cell migration in the absence of external cues is well described by a correlated random walk. Most single cells move by extending protrusions called…”
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Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase by Gotthardt, Katja, Weyand, Michael, Kortholt, Arjan, Van Haastert, Peter JM, Wittinghofer, Alfred

“…Correction to: The EMBO Journal (2008) 27, 2239-2249. doi:10.1038/emboj.2008.150…”
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GxcC connects Rap and Rac signaling during Dictyostelium development by Plak, Katarzyna, Veltman, Douwe, Fusetti, Fabrizia, Beeksma, Jetze, Rivero, Francisco, Van Haastert, Peter J M, Kortholt, Arjan

“…Rap proteins belong to the Ras family of small G-proteins. Dictyostelium RapA is essential and implicated in processes throughout the life cycle. In early…”
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Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling by Keizer-Gunnink, Ineke, Kortholt, Arjan, Van Haastert, Peter J.M

“…During embryonic development, cell movement is orchestrated by a multitude of attractants and repellents. Chemoattractants applied as a gradient, such as cAMP…”
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Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP by Bader, Sonya, Kortholt, Arjan, Van Haastert, Peter J M

“…The Dictyostelium discoideum genome uncovers seven cyclic nucleotide PDEs (phosphodiesterases), of which six have been characterized previously and the seventh…”
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Chemotaxis: signalling modules join hands at front and tail by Postma, Marten, Bosgraaf, Leonard, Loovers, Harriët M, Van Haastert, Peter J M

“…Chemotaxis is the result of a refined interplay among various intracellular molecules that process spatial and temporal information. Here we present a modular…”
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Characterization of the GbpD-activated Rap1 Pathway Regulating Adhesion and Cell Polarity in Dictyostelium discoideum by Kortholt, Arjan, Rehmann, Holger, Kae, Helmut, Bosgraaf, Leonard, Keizer-Gunnink, Ineke, Weeks, Gerald, Wittinghofer, Alfred, Van Haastert, Peter J.M.

“…The regulation of cell polarity plays an important role in chemotaxis. GbpD, a putative nucleotide exchange factor for small G-proteins of the Ras family, has…”
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Erratum To: Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase by Gotthardt, Katja, Weyand, Michael, Kortholt, Arjan, Van Haastert, Peter JM, Wittinghofer, Alfred

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