Search Results - "Van Duyvenvoorde, W"

Butyrate restores HFD-induced adaptations in brain function and metabolism in mid-adult obese mice by Arnoldussen, I A C, Wiesmann, M, Pelgrim, C E, Wielemaker, E M, van Duyvenvoorde, W, Amaral-Santos, P L, Verschuren, L, Keijser, B J F, Heerschap, A, Kleemann, R, Wielinga, P Y, Kiliaan, A J

“…Objective: Midlife obesity affects cognition and increases risk of developing dementia. Recent data suggest that intake of the short chain fatty acid butyrate…”
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Lipid ratios representing SCD1, FADS1, and FADS2 activities as candidate biomarkers of early growth and adiposity by Olga, L., van Diepen, J.A., Bobeldijk-Pastorova, I., Gross, G., Prentice, P.M., Snowden, S.G., Furse, S., Kooistra, T., Hughes, I.A., Schoemaker, M.H., van Tol, E.A.F., van Duyvenvoorde, W., Wielinga, P.Y., Ong, K.K., Dunger, D.B., Kleemann, R., Koulman, A.

“…Altered lipid metabolism in early life has been associated with subsequent weight gain and predicting this could aid in obesity prevention and risk management…”
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Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepatitis in obesity by Mulder, P, Morrison, M C, Wielinga, P Y, van Duyvenvoorde, W, Kooistra, T, Kleemann, R

“…Background: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with abdominal obesity. Growing evidence suggests that inflammation in specific…”
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Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR−/−.Leiden mice by Morrison, M C, Mulder, P, Salic, K, Verheij, J, Liang, W, van Duyvenvoorde, W, Menke, A, Kooistra, T, Kleemann, R, Wielinga, P Y

“…Background/Objectives: Non-alcoholic steatohepatitis (NASH) is a serious liver condition, closely associated with obesity and insulin resistance. Recent…”
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Combined analysis of pharmacokinetic and efficacy data of preclinical studies with statins markedly improves translation of drug efficacy to human trials by van de Steeg, E, Kleemann, R, Jansen, H T, van Duyvenvoorde, W, Offerman, E H, Wortelboer, H M, Degroot, J

“…Correct prediction of human pharmacokinetics (PK) and the safety and efficacy of novel compounds based on preclinical data, is essential but often fails. In…”
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Well-characterized garlic-derived materials are not hypolipidemic in APOE3-Leiden transgenic mice by Espirito Santo, Sonia M S, van Vlijmen, Bart J M, Buytenhek, Rien, van Duyvenvoorde, Wim, Havekes, Louis M, Arnault, Ingrid, Auger, Jacques, Princen, Hans M G

“…Garlic is reported to have beneficial effects on risk factors associated with cardiovascular disease, including normalization of plasma lipid levels. However,…”
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No Effect of Consumption of Green and Black Tea on Plasma Lipid and Antioxidant Levels and on LDL Oxidation in Smokers by Princen, Hans M.G, van Duyvenvoorde, Wim, Buytenhek, Rien, Blonk, Cor, Tijburg, Lilian, Langius, Jacqueline A.E, Meinders, A. Edo, Pijl, Hanno

“…Intake of flavonoids is associated with a reduced cardiovascular risk. Oxidation of LDL is a major step in atherogenesis, and antioxidants may protect LDL from…”
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Acyl-CoA: cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE3-Leiden mice by DELSING, Dianne J. M, OFFERMAN, Erik H, VAN DUYVENVOORDE, Wim, VAN DER BOOM, Hans, DE WIT, Elly C. M, GIJBELS, Marion J. J, VAN DER LAARSE, Arnoud, J. WOUTER, JOUKEMA, HAVEKES, Louis M, PRINCEN, Hans M. G

“…The present study investigated whether the ACAT inhibitor avasimibe can reduce atherogenesis independently of its cholesterol-lowering effect in ApoE*3-Leiden…”
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Supplementation With Low Doses of Vitamin E Protects LDL From Lipid Peroxidation in Men and Women by Princen, Hans M.G, van Duyvenvoorde, Wim, Buytenhek, Rien, van der Laarse, Arnoud, van Poppel, Geert, Gevers Leuven, Jan A, van Hinsbergh, Victor W.M

“…There is accumulating evidence that oxidative modification of LDL is an important step in the process of atherogenesis and that antioxidants may protect LDL…”
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Dietary Plant Stanol Esters Reduce VLDL Cholesterol Secretion and Bile Saturation in Apolipoprotein E3-Leiden Transgenic Mice by Volger, Oscar L, van der Boom, Hans, de Wit, Elly C.M, van Duyvenvoorde, Wim, Hornstra, Gerard, Plat, Jogchum, Havekes, Louis M, Mensink, Ronald P, Princen, Hans M.G

“…ABSTRACT—Dietary plant stanols lower serum cholesterol levels in humans and in hyperlipidemic rodents, mainly by inhibition of the intestinal cholesterol…”
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Effect of fish-oil-enriched margarine on plasma lipids, low-density-lipoprotein particle composition, size, and susceptibility to oxidation by SØRENSEN, N. S, MARCKMANN, P, HØY, C.-E, VAN DUYVENVOORDE, W, PRINCEN, H. M. G

“…We investigated the effect of incorporating n-3 polyunsaturated fatty acids (PUFAs) into the diet on the lipid-class composition of LDLs, their size, and their…”
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Rosuvastatin Reduces Plasma Lipids by Inhibiting VLDL Production and Enhancing Hepatobiliary Lipid Excretion in ApoE3-Leiden Mice by Delsing, Dianne J. M, Post, Sabine M, Groenendijk, Martine, Solaas, Karianne, van der Boom, Hans, van Duyvenvoorde, Wim, de Wit, Elly C. M, Bloks, Vincent W, Kuipers, Folkert, Havekes, Louis M, Princen, Hans M. G

“…The present study was designed to investigate the lipid-lowering properties and mechanisms of action of a new HMG-CoA reductase inhibitor, rosuvastatin, in…”
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Increased lipogenesis and resistance of lipoproteins to oxidative modification in two patients with glycogen storage disease type 1a by Bandsma, Robert H.J., Rake, Jan-Peter, Visser, Gepke, Neese, Richard A., Hellerstein, Marc K., van Duyvenvoorde, Wim, Princen, Hans M.G., Stellaard, Frans, Smit, G.Peter A., Kuipers, Folkert

“…We describe 2 patients with glycogen storage disease type 1a and severe hyperlipidemia without premature atherosclerosis. Susceptibility of low-density…”
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Absence of an atheroprotective effect of the garlic powder printanor in APOE3-Leiden transgenic mice by Santo, Sonia M.S. Espirito, Vlijmen, Bart J.M. van, Duyvenvoorde, Wim van, Offerman, Erik H., Havekes, Louis M., Arnault, Ingrid, Auger, Jacques, Princen, Hans M.G.

“…Numerous animal studies have reported that garlic can protect against atherosclerosis. However, a comparable number of studies do not support this observation…”
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Effect of 17 beta-Estradiol on Plasma Lipids and LDL Oxidation in Postmenopausal Women With Type II Diabetes Mellitus by Brussaard, Hanny E, Leuven, Jan A. Gevers, Kluft, Cornelis, Krans, H. Michiel J, van Duyvenvoorde, Wim, Buytenhek, Rien, van der Laarse, Arnoud, Princen, Hans M.G

“…In type II diabetes mellitus the altered hormonal state after menopause may represent an additional cardiovascular risk factor. Estrogen replacement therapy…”
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Effects of Fish Oil on Oxidation Resistance of VLDL in Hypertriglyceridemic Patients by Hau, Man-Fai, Smelt, Augustinus H.M, Bindels, Alexander J.G.H, Sijbrands, Eric J.G, Van der Laarse, Arnoud, Onkenhout, Willem, van Duyvenvoorde, Wim, Princen, Hans M.G

“…In hypertriglyceridemic (HTG) patients the addition of fish oil to the diet causes a marked reduction in the concentration of triglyceride-rich lipoproteins in…”
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LDL Oxidation and Extent of Coronary Atherosclerosis by van de Vijver, Lucy P.L, Kardinaal, Alwine F.M, Kruijssen, Dick A.C.M, Grobbee, Diederick E, van Poppel, Geert, Princen, Hans M.G

“…Accumulated evidence indicates that oxidative modification of LDL plays an important role in the atherogenic process. Therefore, we investigated the relation…”
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Normal Oxidative Stress and Enhanced Lipoprotein Resistance to In Vitro Oxidation in Hypertriglyceridemia: Effects of Bezafibrate Therapy by de Man, Frits H. A. F, Jonkers, Iris J. A. M, Schwedhelm, Edzard, Smelt, Augustinus H. M, Onkenhout, Willem, van Duyvenvoorde, Wim, Buytenhek, Rien, Leuven, Jan A. Gevers, Troost, Raphael, van der Laarse, Arnoud, Princen, Hans M. G

“…Although there is evidence that hyperlipidemia and predominance of small dense low density lipoproteins (LDLs) are associated with increased oxidative stress,…”
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Dietary vegetable-, wood- or vegetable/wood-derived stanol esters reduce atherosclerotic lesion size and severity in APOE3-Leiden transgenic mice by Volger, O.L, van der Boom, J, de Wit, E.C.M, van Duyvenvoorde, W, Hornstra, G, Plat, J, Havekes, L.M, Princen, H.M.G, Mensink, R.P

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Long term vitamin E feeding attenuates aortic atherosclerosis independent of plasma lipid levels in heterozygous LDL-receptor deficient mice by Volger, O.L, van der Boom, J, van Duyvenvoorde, W, van Wijk, K, Mathot, J, Leenen, R, Roodenburg, A.J.C, Havekes, L.M, Princen, H.M.G

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