Search Results - "Van Duijn, C.M"

ACE Polymorphisms by Sayed-Tabatabaei, F A, Oostra, B A, Isaacs, A, van Duijn, C M, Witteman, J C.M

“…—Angiotensin converting enzyme (ACE) plays an essential role in two physiological systems, one leading to the production of angiotensin II and the other to the…”
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CLEC4M and STXBP5 gene variations contribute to von Willebrand factor level variation in von Willebrand disease by Sanders, Y. V., Bom, J. G., Isaacs, A., Cnossen, M. H., Maat, M. P. M., Laros‐van Gorkom, B. A. P., Fijnvandraat, K., Meijer, K., Duijn, C. M., Mauser‐Bunschoten, E. P., Eikenboom, J., Leebeek, F. W. G., Coppens, M., Kors, A., Meris, J., Nijziel, M. R., Tamminga, R. Y. J., Ypma, P. F., Smiers, F. J. W., Granzen, B., Hamulyák, K., Brons, P.

“…Summary Background von Willebrand factor (VWF) levels in healthy individuals are influenced by variations in genetic loci other than the VWF gene, whose…”
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PARK7, a Novel Locus for Autosomal Recessive Early-Onset Parkinsonism, on Chromosome 1p36 by van Duijn, C.M., Dekker, M.C.J., Bonifati, V., Galjaard, R.J., Houwing-Duistermaat, J.J., Snijders, P.J.L.M., Testers, L., Breedveld, G.J., Horstink, M., Sandkuijl, L.A., van Swieten, J.C., Oostra, B.A., Heutink, P.

“…Although the role of genetic factors in the origin of Parkinson disease has long been disputed, several genes involved in autosomal dominant and recessive…”
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Cathepsin D gene and the risk of Alzheimer's disease: A population-based study and meta-analysis by Schuur, M, Ikram, M.A, van Swieten, J.C, Isaacs, A, Vergeer-Drop, J.M, Hofman, A, Oostra, B.A, Breteler, M.M.B, van Duijn, C.M

“…Abstract Cathepsin D ( CTSD ) is a gene involved in amyloid precursor protein processing and is considered a candidate for Alzheimer's disease (AD). The aim of…”
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Delirium in the Acute Phase After Stroke and the Role of the Apolipoprotein E Gene by Oldenbeuving, A.W., M.D, de Kort, P.L.M., M.D., Ph.D, Kappelle, L.J., M.D., Ph.D, van Duijn, C.M., M.D., Ph.D, Roks, G., M.D., Ph.D

“…Objective To study the association between the epsilon 4 allele of apolipoprotein E (APOEε4) and delirium in a stroke population. Methods 527 consecutive…”
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Heritability of the function and structure of the arterial wall : Findings of the erasmus rucphen family (ERF) study by SAYED-TABATABAEI, F. A, VAN RIJN, M. J. E, SCHUT, A. F. C, AULCHENKO, Y. S, CROES, E. A, ZILLIKENS, M. C, POLS, H. A. P, WITTEMAN, J. C. M, OOSTRA, B. A, VAN DUIJN, C. M

“…Using 930 individuals connected in a single pedigree from an isolated population, participants of the Erasmus Rucphen Family (ERF) study, we investigated the…”
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Genetic variation in the C-reactive protein gene and arterial stiffness: The Rotterdam Study by Sie, M.P.S, Mattace-Raso, F.U.S, Kardys, I, de Maat, M.P.M, Uitterlinden, A.G, Hofman, A, Hoeks, A.P.G, Reneman, R.S, Asmar, R, van Duijn, C.M, Witteman, J.C.M

“…Summary Background and aim Arterial stiffness increases with age and has been found to predict cardiovascular disease. C-reactive protein (CRP) is an…”
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The impact of apolipoprotein E on dementia in persons with Down's syndrome by Coppus, A.M.W, Evenhuis, H.M, Verberne, G.-J, Visser, F.E, Arias-Vasquez, A, Sayed-Tabatabaei, F.A, Vergeer-Drop, J, Eikelenboom, P, van Gool, W.A, van Duijn, C.M

“…Abstract Apolipoprotein E (APOE) is consistently associated with dementia in the general population. Findings on the role of this gene in persons with Down's…”
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HFE variants, APOE and Alzheimer's disease: Findings from the population-based Rotterdam Study by Alizadeh, B.Z, Njajou, O.T, Millán, M.R, Hofman, A, Breteler, M.M, van Duijn, C.M

“…Abstract Iron is a reactive oxygen species and has been implicated in the pathogenesis of Alzheimer's disease (AD). In a population-based cohort study,…”
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Transforming-growth factor β1 Leu10Pro polymorphism and breast cancer morbidity by González-Zuloeta Ladd, A.M, Arias-Vásquez, A, Siemes, C, Coebergh, J.W.W, Hofman, A, Witteman, J, Uitterlinden, A, Stricker, B.H.Ch, van Duijn, C.M

“…Abstract TGF-β1 has a dual role in carcinogenesis. In this gene, a leucine to proline substitution in codon 10 leads to higher circulating levels of TGF-β1 …”
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376 META-ANALYSIS OF GENOME-WIDE ASSOCIATION DATA IMPLICATES THE 4P15.3 REGION TO INFLUENCE CHRONIC WIDESPREAD PAIN IN WOMEN by Peters, M.J, van Wingerden, S.H, Popham, M, Kerkhof, H.J, Stolk, L, Rivadeira, F, van Duijn, C.M, Hofman, A, Williams, F.M, Uitterlinden, A.G, van Meurs, J.B

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Polymorphism in the promoter region of the insulin-like growth factor I gene is related to carotid intima-media thickness and aortic pulse wave velocity in subjects with hypertension by SCHUT, A. F. C, JANSSEN, J. A. M. J. L, DEINUM, J, VERGEER, J. M, HOFMAN, A, LAMBERTS, S. W. J, OOSTRA, B. A, POLS, H. A. P, WITTEMAN, J. C. M, VAN DUIJN, C. M

“…Low circulating levels of insulin-like growth factor I (IGF-I) have been associated with an increased risk for atherosclerosis. Absence of the 192-bp…”
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P.8.a.005 Plasma amino acids and neopterin in healthy subjects with Down's syndrome by Verhoeven, W.M.A, Coppus, A.M.W, Fekkes, D, Tuinier, S, Egger, J.I.M, Van Duijn, C.M

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IGF-1 CA repeat variant and breast cancer risk in postmenopausal women by González-Zuloeta Ladd, A.M, Liu, F, Houben, M.P.W.A, Arias Vásquez, A, Siemes, C, Janssens, A.C.J.W, Coebergh, J.W.W, Hofman, A, Janssen, J.A.M.J.L, Stricker, B.H.Ch, van Duijn, C.M

“…Abstract IGF-I is an important growth factor for the mammary gland. We evaluated the relationship of the IGF-I CA n polymorphism with breast cancer risk in…”
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Heritability of serum iron, ferritin and transferrin saturation in a genetically isolated population, the Erasmus Rucphen Family (ERF) Study by Njajou, O T, Alizadeh, B Z, Aulchenko, Y, Zillikens, M C, Pols, H A P, Oostra, B A, Swinkels, D W, van Duijn, C M

“…Iron has been implicated in the pathogenesis of various disorders. Mutations in the HFE gene are associated with an increase in serum iron parameters. The aim…”
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A systematic evaluation of 151 candidate genes for their association with osteoporosis and osteoporotic fracture in a meta-analysis of genome-wide association data by Richards, J, Kavvoura, F.K, Rivadeneira, F, Styrkarsdottir, U, Estrada, K, Halldorsson, B, Hsu, Y, Zillikens, M, Wilson, S.G, Mullins, B, Amin, N, Aulchenko, Y.A, Cupples, L, Deloukas, P, Demissie, S, Hofman, A, Kong, A, Karasik, D, van Meurs, J.M, Oostra, B, Pols, H.A.P, Sigurdsson, G, Thorsteinsdottir, U, Soranzo, N, Williams, F.M.K, Zhou, Y, Ralston, S, Thorleifsson, G, van Duijn, C.M, Kiel, D, Stefansson, K, Uitterlinden, A, Ioannidis, J.P.A, Spector, T.D

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Cerebrovascular risk factors do not contribute to genetic variance of cognitive function by Sleegers, K, de Koning, I, Aulchenko, Y.S, van Rijn, M.J.E, Houben, M.P.W.A, Croes, E.A, van Swieten, J.C, Oostra, B.A, van Duijn, C.M

“…Abstract Impaired cognition in later life may result from Alzheimer's disease-related pathology, but also from vascular pathology. We studied to what extent…”
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297 A NON-SYNONYMOUS SNP IN GENE ASSOCIATED WITH SUSCEPTIBILITY TO SYMPTOMATIC OSTEOARTHRITIS by Meulenbelt, I, Min, J.L, Bos, S, Riyazi, N, Houwing-Duistermaat, J.J, van der Wijk, H, Kroon, H.M, Uitterlinden, A.G, van Meurs, J.B, van der Deure, W.M, Visser, T.J, Seymour, A.B, Lakenberg, N, ter Breggen, R, Kremer, D, van Duijn, C.M, Kloppenburg, M, Loughlin, J, Slagboom, P.E

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The Impact of Genetic Testing on Complex Diseases by van Rijn, M. J. E., van Duijn, C. M., Slooter, A. J. C.

“…Objective: Wide applications for genetic testing in the clinical care of complex diseases have been discussed. However, it has never been quantified to what…”
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Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7 by Bonifati, V, Dekker, M C J, Vanacore, N, Fabbrini, G, Squitieri, F, Marconi, R, Antonini, A, Brustenghi, P, Dalla Libera, A, De Mari, M, Stocchi, F, Montagna, P, Gallai, V, Rizzu, P, van Swieten, J C, Oostra, B, van Duijn, C M, Meco, G, Heutink, P

“…Autosomal recessive, early onset parkinsonism (AREP) is genetically heterogeneous. Mutations in the parkin gene (PARK2 locus, chromosome 6q) account for up to…”
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