Search Results - "Van Dongen, Jacques J.M."

CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency by van Zelm, Menno C, Smet, Julie, Adams, Brigitte, Mascart, Françoise, Schandené, Liliane, Janssen, Françoise, Ferster, Alina, Kuo, Chiung-Chi, Levy, Shoshana, van Dongen, Jacques J M, van der Burg, Mirjam

“…Antibody deficiencies constitute the largest group of symptomatic primary immunodeficiency diseases. In several patients, mutations in CD19 have been found to…”
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Overview of clinical flow cytometry data analysis: recent advances and future challenges by Pedreira, Carlos E, Costa, Elaine S, Lecrevisse, Quentin, van Dongen, Jacques J.M, Orfao, Alberto

“…Highlights • Polychromatic flow cytometry generates increasingly complex n -dimensional data sets. • New tools are being created for objective flow cytometry…”
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Distinct early cellular kinetics in participants protected against colonization upon Bordetella pertussis challenge by Diks, Annieck M, de Graaf, Hans, Teodosio, Cristina, Groenland, Rick J, de Mooij, Bas, Ibrahim, Muktar, Hill, Alison R, Read, Robert C, van Dongen, Jacques Jm, Berkowska, Magdalena A

“…BACKGROUNDTo date, only limited data are available on the mechanisms of protection against colonization with Bordetella pertussis in humans.METHODSIn this…”
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Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion by Luis, Tiago C., Naber, Brigitta A.E., Roozen, Paul P.C., Brugman, Martijn H., de Haas, Edwin F.E., Ghazvini, Mehrnaz, Fibbe, Willem E., van Dongen, Jacques J.M., Fodde, Riccardo, Staal, Frank J.T.

“…Canonical Wnt signaling has been implicated in the regulation of hematopoiesis. By employing a Wnt-reporter mouse, we observed that Wnt signaling is…”
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Multicolor Flowcytometric Immunophenotyping Is a Valuable Tool for Detection of Intraocular Lymphoma by Missotten, Tom, MD, Tielemans, Dennis, MSc, Bromberg, Jacolien E., MD, PhD, van Hagen, P. Martin, PhD, van Lochem, Ellen G., MD, PhD, van Dongen, Jacques J.M., MD, PhD, Baarsma, G. Seerp, MD, Langerak, Anton W., PhD

“…Objective Intraocular lymphoma (IOL) is a rare condition and frequently difficult to distinguish from uveitis or other uveitis-masquerading syndromes. The…”
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Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection by Miedema, Frank, Hazenberg, Mette D, Otto, Sigrid A, Stuart, James W.T. Cohen, Verschuren, Martie C.M, Borleffs, Jan C.C, Boucher, Charles A.B, Coutinho, Roel A, Lange, Joep M.A, de Wit, Tobias F. Rinke, Tsegaye, Aster, van Dongen, Jacques J.M, Hamann, Dörte, de Boer, Rob J

“…Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs…”
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Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood by Blanco, Elena, Pérez-Andrés, Martín, Arriba-Méndez, Sonia, Contreras-Sanfeliciano, Teresa, Criado, Ignacio, Pelak, Ondrej, Serra-Caetano, Ana, Romero, Alfonso, Puig, Noemí, Remesal, Ana, Torres Canizales, Juan, López-Granados, Eduardo, Kalina, Tomas, Sousa, Ana E., van Zelm, Menno, van der Burg, Mirjam, van Dongen, Jacques J.M., Orfao, Alberto

“…Humoral immunocompetence develops stepwise throughout life and contributes to individual susceptibility to infection, immunodeficiency, autoimmunity, and…”
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Genetic defects in PI3Kδ affect B-cell differentiation and maturation leading to hypogammaglobulineamia and recurrent infections by Wentink, Marjolein, Dalm, Virgil, Lankester, Arjan C, van Schouwenburg, Pauline A, Schölvinck, Liesbeth, Kalina, Tomas, Zachova, Radana, Sediva, Anna, Lambeck, Annechien, Pico-Knijnenburg, Ingrid, van Dongen, Jacques J.M, Pac, Malgorzata, Bernatowska, Ewa, van Hagen, Martin, Driessen, Gertjan, van der Burg, Mirjam

“…Abstract Background Mutations in PIK3CD and PIK3R1 cause activated PI3K-δ syndrome (APDS) by dysregulation of the PI3K-AKT pathway. Methods We studied…”
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Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion by van Zelm, Menno C, Szczepanski, Tomasz, van der Burg, Mirjam, van Dongen, Jacques J M

“…The contribution of proliferation to B lymphocyte homeostasis and antigen responses is largely unknown. We quantified the replication history of mouse and…”
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Human IgE+ B cells are derived from T cell–dependent and T cell–independent pathways by Berkowska, Magdalena A., PhD, Heeringa, Jorn J., MD, Hajdarbegovic, Enes, MD, van der Burg, Mirjam, PhD, Thio, H. Bing, MD, PhD, van Hagen, P. Martin, MD, PhD, Boon, Louis, PhD, Orfao, Alberto, MD, PhD, van Dongen, Jacques J.M., MD, PhD, van Zelm, Menno C., PhD

“…Background The prevalence of IgE-mediated diseases has been increasing worldwide, yet IgE-expressing B cells are poorly characterized, mainly because of their…”
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The 3D Structure of the Immunoglobulin Heavy-Chain Locus: Implications for Long-Range Genomic Interactions by Jhunjhunwala, Suchit, van Zelm, Menno C., Peak, Mandy M., Cutchin, Steve, Riblet, Roy, van Dongen, Jacques J.M., Grosveld, Frank G., Knoch, Tobias A., Murre, Cornelis

“…The immunoglobulin heavy-chain ( Igh) locus is organized into distinct regions that contain multiple variable (V H), diversity (D H), joining (J H) and…”
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Phenotypic profiling of CD34 + cells by advanced flow cytometry improves diagnosis of juvenile myelomonocytic leukemia by Bugarin, Cristina, Antolini, Laura, Buracchi, Chiara, Matarraz, Sergio, Coliva, Tiziana Angela, Van der Velden, Vincent H, Szczepanski, Tomasz, Da Costa, Elaine Sobral, Van der Sluijs, Alita, Novakova, Michaela, Mejstrikova, Ester, Nierkens, Stefan, De Mello, Fabiana Vieira, Fernandez, Paula, Aanei, Carmen, Sędek, Łukasz, Strocchio, Luisa, Masetti, Riccardo, Sainati, Laura, Philippé, Jan, Valsecchi, Maria Grazia, Locatelli, Franco, Van Dongen, Jacques J M, Biondi, Andrea, Orfao, Alberto, Gaipa, Giuseppe

“…Diagnostic criteria for juvenile myelomonocytic leukemia (JMML) are currently well defined, however in some patients diagnosis still remains a challenge. Flow…”
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The nature of circulating CD27+CD43+ B cells by Perez-Andres, Martin, Grosserichter-Wagener, Christina, Teodosio, Cristina, van Dongen, Jacques J M, Orfao, Alberto, van Zelm, Menno C

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An Antibody-Deficiency Syndrome Due to Mutations in the CD19 Gene by van Zelm, Menno C, Reisli, Ismail, van der Burg, Mirjam, Castaño, Diana, van Noesel, Carel J.M, van Tol, Maarten J.D, Woellner, Cristina, Grimbacher, Bodo, Patiño, Pablo J, van Dongen, Jacques J.M, Franco, José L

“…Four patients from two unrelated families with increased susceptibility to infection, hypogammaglobulinemia, and normal numbers of B cells in the blood were…”
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Performance of spectral flow cytometry and mass cytometry for the study of innate myeloid cell populations by van der Pan, Kyra, Khatri, Indu, de Jager, Anniek L, Louis, Alesha, Kassem, Sara, Naber, Brigitta A E, de Laat, Inge F, Hameetman, Marjolijn, Comans, Suzanne E T, Orfao, Alberto, van Dongen, Jacques J M, Díez, Paula, Teodosio, Cristina

“…Monitoring of innate myeloid cells (IMC) is broadly applied in basic and translational research, as well as in diagnostic patient care. Due to their…”
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Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity by Driessen, Gertjan J., MD, IJspeert, Hanna, MSc, Weemaes, Corry M.R., MD, PhD, Haraldsson, Ásgeir, MD, PhD, Trip, Margreet, MD, Warris, Adilia, MD, PhD, van der Flier, Michiel, MD, PhD, Wulffraat, Nico, MD, PhD, Verhagen, Mijke M.M., MD, PhD, Taylor, Malcolm A., MD, PhD, van Zelm, Menno C., PhD, van Dongen, Jacques J.M., MD, PhD, van Deuren, Marcel, MD, PhD, van der Burg, Mirjam, PhD

“…Background Ataxia telangiectasia (AT) is a multisystem DNA-repair disorder caused by mutations in the ataxia telangiectasia mutated (ATM) gene. Patients with…”
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Effects of nongenetic factors on immune cell dynamics in early childhood: The Generation R Study by van den Heuvel, Diana, PhD, Jansen, Michelle A.E., MD, Nasserinejad, Kazem, MSc, Dik, Willem A., PhD, van Lochem, Ellen G., PhD, Bakker-Jonges, Liesbeth E., PhD, Bouallouch-Charif, Halima, BSc, Jaddoe, Vincent W.V., MD, PhD, Hooijkaas, Herbert, PhD, van Dongen, Jacques J.M., MD, PhD, Moll, Henriëtte A., MD, PhD, van Zelm, Menno C., PhD

“…Background Numbers of blood leukocyte subsets are highly dynamic in childhood and differ greatly between subjects. Interindividual variation is only partly…”
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The New EU Regulation on In Vitro Diagnostic Medical Devices: Implications and Preparatory Actions for Diagnostic Laboratories by Lubbers, Bart R., Schilhabel, Anke, Cobbaert, Christa M., Gonzalez, David, Dombrink, Isabel, Brüggemann, Monika, Bitter, W. Marieke, Dongen, Jacques J.M.

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Human CD19 and CD40L deficiencies impair antibody selection and differentially affect somatic hypermutation by van Zelm, Menno C., PhD, Bartol, Sophinus J.W., BSc, Driessen, Gertjan J., MD, PhD, Mascart, Françoise, MD, PhD, Reisli, Ismail, MD, Franco, Jose L., MD, Wolska-Kusnierz, Beata, MD, Kanegane, Hirokazu, MD, PhD, Boon, Louis, PhD, van Dongen, Jacques J.M., MD, PhD, van der Burg, Mirjam, PhD

“…Background Individuals with genetic defects in CD40 ligand (CD40L) or B-cell antigen receptor coreceptor molecules CD19 and CD81 suffer from an antibody…”
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Responsiveness of chronic lymphocytic leukemia cells to B-cell receptor stimulation is associated with low expression of regulatory molecules of the nuclear factor-κB pathway by Meijers, Ruud W J, Muggen, Alice F, Leon, Leticia G, de Bie, Maaike, van Dongen, Jacques J M, Hendriks, Rudi W, Langerak, Anton W

“…Chronic lymphocytic leukemia (CLL) is a disease with heterogeneous clinical and biological characteristics. Differences in Ca levels among cases, both basal…”
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