Search Results - "Van Dierendonck, J. H."

A new method to detect apoptosis in paraffin sections: in situ end- labeling of fragmented DNA by Wijsman, JH, Jonker, RR, Keijzer, R, van de Velde, CJ, Cornelisse, CJ, van Dierendonck, JH

“…Apoptosis (programmed cell death) can be difficult to detect in routine histological sections. Since extensive DNA fragmentation is an important characteristic…”
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Specific tumor-cell killing with adenovirus vectors containing the apoptin gene by Pietersen, A M, van der Eb, M M, Rademaker, H J, van den Wollenberg, D J, Rabelink, M J, Kuppen, P J, van Dierendonck, J H, van Ormondt, H, Masman, D, van de Velde, C J, van der Eb, A J, Hoeben, R C, Noteborn, M H

“…Specificity is an essential prerequisite for cancer gene therapy. Recently we described that apoptin, a protein of 121 amino acids which is derived from the…”
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Increased local cytostatic drug exposure by isolated hepatic perfusion: a phase I clinical and pharmacologic evaluation of treatment with high dose melphalan in patients with colorectal cancer confined to the liver by VAHRMEIJER, A. L, VAN DIERENDONCK, J. H, VAN DE VELDE, C. J. H, KEIZER, H. J, BEIJNEN, J. H, TOLLENAAR, R. A. E. M, PIJL, M. E. J, MARINELLI, A, KUPPEN, P. J. K, VAN BOCKEL, J. H, MULDER, G. J

“…A phase I dose-escalation study was performed to determine whether isolated hepatic perfusion (IHP) with melphalan (L-PAM) allows exposure of the liver to much…”
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Loss of Bcl-2 in invasive breast cancer is associated with high rates of cell death, but also with increased proliferative activity by VAN SLOOTEN, H.-J, VAN DE VIJVER, M. J, VAN DE VELDE, C. J. H, VAN DIERENDONCK, J. H

“…Bcl-2 has been demonstrated to inhibit apoptosis in breast cancer cells in vitro, and the ratio between Bcl-2 and its proapoptotic homologue Bax seems to be an…”
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Immunohistochemical detection of p53 and Bcl-2 in colorectal carcinoma: no evidence for prognostic significance by TOLLENAAR, R. A. E. M, VAN KRIEKEN, J. H. J. M, VAN SLOOTEN, H.-J, BRUINVELS, D. J, NELEMANS, K. M. J, VAN DEN BROEK, L. J, HERMANS, J, VAN DIERENDONCK, J. H

“…To evaluate the prognostic significance of immunohistochemically detected p53 and Bcl-2 proteins in colorectal cancer, tissue sections from 238…”
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Ki-67 detects a nuclear matrix-associated proliferation-related antigen. II: Localization in mitotic cells and association with chromosomes by VERHEIJEN, R, KUIJPERS, H. J. H, VAN DRIEL, R, BECK, J. L. M, VAN DIERENDONCK, J. H, BRAKENHOFF, G. J, RAMAEKERS, F. C. S

“…In interphase cells the proliferation-associated antigen recognized by monoclonal antibody Ki-67 is almost exclusively located in the nucleoli. When cells at…”
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Cell-cycle-related staining patterns of anti-proliferating cell nuclear antigen monoclonal antibodies. Comparison with BrdUrd labeling and Ki- 67 staining by van Dierendonck, JH, Wijsman, JH, Keijzer, R, van de Velde, CJ, Cornelisse, CJ

“…Monoclonal antibodies (MAbs) to nuclear antigens are increasingly used as tools to obtain valuable information concerning the proliferative characteristics of…”
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The role of various Bcl-2 domains in the anti-proliferative effect and modulation of cellular glutathione levels: a prominent role for the BH4 domain by Hoetelmans, R. W. M., Vahrmeijer, A. L., Van Vlierberghe, R. L. P., Keijzer, R., Van De Velde, C. J. H., Mulder, G. J., Van Dierendonck, J. H.

“… Reduced cell proliferation and increased levels of cellular glutathione (GSH) are characteristic for cells that overexpress the anti‐apoptotic Bcl‐2 protein…”
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Interstitial photodynamic therapy with the second-generation photosensitizer bacteriochlorin a in a rat model for liver metastases by ROVERS, J. P, SCHUITMAKER, J. J, VAHRMEIJER, A. L, VAN DIERENDONCK, J. H, TERPSTRA, O. T

“…Bacteriochlorin a (BCA) is a second-generation photosensitizer that is effective in tumour destruction upon illumination with light of a wavelength of 760 nm…”
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Bcl-2 and Bax proteins are present in interphase nuclei of mammalian cells by Hoetelmans, R, van Slooten, H J, Keijzer, R, Erkeland, S, van de Velde, C J, Dierendonck, J H

“…The Bcl-2 family of proteins comprises both cell death inhibiting and cell death promoting members, generally believed to be cytoplasmic and predominantly…”
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Outgrowth of BT-474 human breast cancer cells in immune-deficient mice : a new in vivo model for hormone-dependent breast cancer by VAN SLOOTEN, H.-J, BONSING, B. A, HILLER, A. J, COLBERN, G. T, VAN DIERENDONCK, J. H, CORNELISSE, C. J, SMITH, H. S

“…The effect of co-inoculation of basement membrane matrix, Matrigel and two human breast cancer cell lines, BT-474 and SK-BR-3, was tested in immune-deficient…”
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Expression of Bcl-2 in node-negative breast cancer is associated with various prognostic factors, but does not predict response to one course of perioperative chemotherapy by VAN SLOOTEN, H.-J, CLAHSEN, P. C, VAN DIERENDOCK, J. H, DUVAL, C, PALLUD, C, MANDARD, A.-M, DELOBELLE-DEROIDE, A, VAN DE VELDE, C. J. H, VAN DE VIJVER, M. J

“…The aim of this study was to assess relationships between Bcl-2 expression, response to chemotherapy and a number of pathological and biological tumour…”
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Effect of glutathione depletion on inhibition of cell cycle progression and induction of apoptosis by melphalan (L-phenylalanine mustard) in human colorectal cancer cells by Vahrmeijer, Alexander L, van Dierendonck, Jan Hein, Schutrups, Jan, van de Velde, Cornelis J.H, Mulder, Gerard J

“…Intracellular levels of glutathione have been shown to affect the sensitivity of cells to cell death-inducing stimuli, as well as the mode of cell death. We…”
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Microwave-enhanced in situ end-labeling of fragmented DNA: parametric studies in relation to postmortem delay and fixation of rat and human brain by Lucassen, PJ, Chung, WC, Vermeulen, JP, Van Lookeren Campagne, M, Van Dierendonck, JH, Swaab, DF

“…In situ end-labeling (ISEL) identifies DNA fragmentation in apoptotic or necrotic nuclei in tissue sections. However, application of ISEL on human brain…”
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Effect of hormone depletion on cell survival in the EMR-86 rat mammary carcinoma by WIJSMAN, J. H, CORNELISSE, C. J, KEIJZER, R, VAN DE VELDE, C. J. H, ELVERS, B, VAN DIERENDONCK, J. H

“…Growth of the transplantable EMR-86 rat mammary carcinoma depends on elevated prolactin levels which are induced by oestrogenic stimulation of the pituitary…”
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Increasing the effective concentration of melphalan in experimental rat liver tumours: comparison of isolated liver perfusion and hepatic artery infusion by MARINELLI, A, VAN DIERENDONCK, J. H, VAN BRAKEL, G. M, IRTH, H, KUPPEN, P. J. K, TJADEN, U. R, VAN DE VELDE, C. J. H

“…Regional chemotherapy allows further exploitation of the steep dose response curve of most chemotherapeutic agents, while systemic toxicity remains tolerable…”
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A prolactin-dependent, metastasising rat mammary carcinoma as a model for endocrine-related tumour dormancy by WIJSMAN, J. H, CORNELISSE, C. J, KEIJZER, R, VAN DE VELDE, C. J. H, VAN DIERENDONCK, J. H

“…In order to study the growth kinetics of breast tumours during long-term hormonal withdrawal, we developed a transplantable, invasive mammary carcinoma EMR-86…”
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Mutations in exons 5-8 of the p53 gene, independent of their type and location, are associated with increased apoptosis and mitosis in invasive breast carcinoma by van Slooten, Henk-Jan, van de Vijver, Marc J., Børresen, Anne-Lise, Eyfjörd, Jorunn E., Valgardsdóttir, Rut, Scherneck, Siegfried, Nesland, Jahn M., Devilee, Peter, Cornelisse, Cees J., van Dierendonck, Jan Hein

“…In breast cancer, mutations located in the zinc‐binding functional domains of the p53 gene have been reported to predict a worse prognosis and a worse response…”
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The presence of 19-kDa Bcl-2 in dividing cells by Hoetelmans, R. W. M., Van de Velde, C. J. H., Van Dierendonck, J. H.

“…The 26-kDa bcl-2 gene product inhibits apoptosis and cell proliferation. Cleavage of Bcl-2 into a 22-kDa fragment inactivates its anti-apoptotic activity and…”
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Effectiveness of isolated liver perfusion with mitomycin C in the treatment of liver tumours of rat colorectal cancer by MARINELLI, A, DIJKSTRA, F. R, VAN DIERENDONCK, J. H, KUPPEN, P. J. K, CORNELISSE, C. J, VAN DE VELDE, C. J. H

“…Dose limiting systemic toxicity prevents sufficient exploitation of the steep dose response relationship of most anticancer agents. In our rat liver tumour…”
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