Search Results - "Van Deventer, James A."

Future prospects for noncanonical amino acids in biological therapeutics by Rezhdo, Arlinda, Islam, Mariha, Huang, Manjie, Van Deventer, James A

“…[Display omitted] •Use of noncanonical amino acid (ncAAs) in therapeutics requires careful evaluation.•NcAA-mediated strategies enable important routes to…”
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Engineering Selectively Targeting Antimicrobial Peptides by Lei, Ming, Jayaraman, Arul, Van Deventer, James A, Lee, Kyongbum

“…The rise of antibiotic-resistant strains of bacterial pathogens has necessitated the development of new therapeutics. Antimicrobial peptides (AMPs) are a class…”
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Desperately seeking sortase by Van Deventer, James A.

“…Directed evolution on the yeast cell surface enables the discovery of sortase variants with altered specificity capable of modifying Aβ peptides under…”
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ASAP-SML: An antibody sequence analysis pipeline using statistical testing and machine learning by Li, Xinmeng, Van Deventer, James A, Hassoun, Soha

“…Antibodies are capable of potently and specifically binding individual antigens and, in some cases, disrupting their functions. The key challenge in generating…”
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Hydration dynamics at fluorinated protein surfaces by Kwon, Oh-Hoon, Yoo, Tae Hyeon, Othon, Christina M., Van Deventer, James A., Tirrell, David A., Zewail, Ahmed H.

“…Water-protein interactions dictate many processes crucial to protein function including folding, dynamics, interactions with other biomolecules, and enzymatic…”
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Liven Up That Linker by Van Deventer, James A

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Genome-Wide Screen for Enhanced Noncanonical Amino Acid Incorporation in Yeast by Lino, Briana R, Van Deventer, James A

“…Expanding the genetic code beyond the 20 canonical amino acids enables access to a wide range of chemical functionality that is inaccessible within…”
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Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications by Johnson, Jeremiah A, Lu, Ying Y, Van Deventer, James A, Tirrell, David A

“…Residue-specific incorporation of non-canonical amino acids into proteins allows facile alteration and enhancement of protein properties. In this review, we…”
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Incorporating, Quantifying, and Leveraging Noncanonical Amino Acids in Yeast by Stieglitz, Jessica T, Van Deventer, James A

“…Genetic code expansion has allowed for extraordinary advances in enhancing protein chemical diversity and functionality, but there remains a critical need for…”
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Reaching New Heights in Genetic Code Manipulation with High Throughput Screening by Lino, Briana R., Williams, Sean J., Castor, Michelle E., Van Deventer, James A.

“…The chemical and physical properties of proteins are limited by the 20 canonical amino acids. Genetic code manipulation allows for the incorporation of…”
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Dual Noncanonical Amino Acid Incorporation Enabling Chemoselective Protein Modification at Two Distinct Sites in Yeast by Lahiri, Priyanka, Martin, Meghan S., Lino, Briana R., Scheck, Rebecca A., Van Deventer, James A.

“…Incorporation of more than one noncanonical amino acid (ncAA) within a single protein endows the resulting construct with multiple useful features such as…”
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High-Throughput Aminoacyl-tRNA Synthetase Engineering for Genetic Code Expansion in Yeast by Stieglitz, Jessica T., Van Deventer, James A.

“…Protein expression with genetically encoded noncanonical amino acids (ncAAs) benefits a broad range of applications, from the discovery of biological…”
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Strategies for enriching and characterizing proteins with inhibitory properties on the yeast surface by Rezhdo, Arlinda, Lessard, Catherine T, Islam, Mariha, Van Deventer, James A

“…Abstract Display technologies are powerful tools for discovering binding proteins against a broad range of biological targets. However, it remains challenging…”
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Flow cytometric evaluation of yeast–bacterial cell–cell interactions by Lei, Ming, Trivedi, Vikas D., Nair, Nikhil U., Lee, Kyongbum, Van Deventer, James A.

“…Synthetic cell–cell interaction systems can be useful for understanding multicellular communities or for screening binding molecules. We adapt a previously…”
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Systematic Evaluation of Protein-Small Molecule Hybrids on the Yeast Surface by Huang, Manjie, Rueda-Garcia, Marina, Harthorn, Abbigael, Hackel, Benjamin J., Van Deventer, James A.

“…Protein-small molecule hybrids are structures that have the potential to combine the inhibitory properties of small molecules and the specificities of binding…”
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Editorial overview: Pharmaceutical biotechnology: new frontiers in protein, gene, and cell therapies by Chen, Yvonne Y, Van Deventer, James A

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Yeast Display Enables Identification of Covalent Single-Domain Antibodies against Botulinum Neurotoxin Light Chain A by Alcala-Torano, Rafael, Islam, Mariha, Cika, Jaclyn, Lam, Kwok Ho, Jin, Rongsheng, Ichtchenko, Konstantin, Shoemaker, Charles B., Van Deventer, James A.

“…While covalent drug discovery is reemerging as an important route to small-molecule therapeutic leads, strategies for the discovery and engineering of…”
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Engineering Proteins Containing Noncanonical Amino Acids on the Yeast Surface by Hershman, Rebecca L, Rezhdo, Arlinda, Stieglitz, Jessica T, Van Deventer, James A

“…Yeast display has been used to advance many critical research areas, including the discovery of unique protein binders and biological therapeutics. In…”
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Genome-Wide Screen for Enhanced Noncanonical Amino Acid Incorporation in Yeast by Zackin, Matthew T., Stieglitz, Jessica T., Van Deventer, James A.

“…Numerous applications of noncanonical amino acids (ncAAs) in basic biology and therapeutic development require efficient protein biosynthesis using an expanded…”
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Intracellular Delivery of Antibodies for Selective Cell Signaling Interference by Hershman, Rebecca L., Li, Yamin, Ma, Feihe, Xu, Qioabing, Van Deventer, James A.

“…Many intracellular signaling events remain poorly characterized due to a general lack of tools to interfere with “undruggable” targets. Antibodies have the…”
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