Search Results - "Van Der Horst, Gijsbertus T. J."

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis by Robinson, Andria Rasile, Appeldoorn, Esther, Hoeijmakers, Jan H. J, Theil, Arjan F, Raams, Anja, Odijk, Hanny, Kleijer, Wim J, Meinecke, Peter, van Leeuwen, Wibeke, Lalai, Astrid S, Ahmad, Anwaar, Niedernhofer, Laura J, Vijg, Jan, Jaspers, Nicolaas G. J, Garinis, George A, Vermeulen, Wim, van der Horst, Gijsbertus T. J, Oostendorp, Roos

“…XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA lesions and cytotoxic DNA interstrand crosslinks. Mild mutations in XPF cause the…”
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Social Jetlag and Related Risks for Human Health: A Timely Review by Caliandro, Rocco, Streng, Astrid A, van Kerkhof, Linda W M, van der Horst, Gijsbertus T J, Chaves, Inês

“…The term social jetlag is used to describe the discrepancy between biological time, determined by our internal body clock, and social times, mainly dictated by…”
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Biomarkers for circadian rhythm disruption independent of time of day by Van Dycke, Kirsten C G, Pennings, Jeroen L A, van Oostrom, Conny T M, van Kerkhof, Linda W M, van Steeg, Harry, van der Horst, Gijsbertus T J, Rodenburg, Wendy

“…Frequent shift work causes disruption of the circadian rhythm and might on the long-term result in increased health risk. Current biomarkers evaluating the…”
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Molecular Mechanisms of the Biological Clock in Cultured Fibroblasts by Yagita, Kazuhiro, Tamanini, Filippo, Gijsbertus T. J. van der Horst, Okamura, Hitoshi

“…In mammals, the central circadian pacemaker resides in the hypothalamic suprachiasmatic nucleus (SCN), but circadian oscillators also exist in peripheral…”
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Clinical chronobiology: a timely consideration in critical care medicine by McKenna, Helen, van der Horst, Gijsbertus T J, Reiss, Irwin, Martin, Daniel

“…A fundamental aspect of human physiology is its cyclical nature over a 24-h period, a feature conserved across most life on Earth. Organisms compartmentalise…”
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Circadian Variation in Human Milk Composition, a Systematic Review by Italianer, Merel F, Naninck, Eva F G, Roelants, Jorine A, van der Horst, Gijsbertus T J, Reiss, Irwin K M, Goudoever, Johannes B van, Joosten, Koen F M, Chaves, Inês, Vermeulen, Marijn J

“…Breastfeeding is considered the most optimal mode of feeding for neonates and mothers. Human milk changes over the course of lactation in order to perfectly…”
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Night shift work characteristics are associated with several elevated metabolic risk factors and immune cell counts in a cross-sectional study by Streng, Astrid A., Loef, Bette, Dollé, Martijn E. T., van der Horst, Gijsbertus T. J., Chaves, Inês, Proper, Karin I., van Kerkhof, Linda W. M.

“…Night shift work is associated with increased health risks. Here we examined the association of metabolic risk factors and immune cell counts, with both night…”
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Vagal Regulation of Respiratory Clocks in Mice by Bando, Hideki, Nishio, Takeshi, van der Horst, Gijsbertus T. J, Masubuchi, Satoru, Hisa, Yasuo, Okamura, Hitoshi

“…The present study addresses the role of the circadian system in day-night changes of respiratory functions in the mouse. In all airway tissues investigated…”
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CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock by Tamaru, Teruya, Hattori, Mitsuru, Honda, Kousuke, Nakahata, Yasukazu, Sassone-Corsi, Paolo, van der Horst, Gijsbertus T J, Ozawa, Takeaki, Takamatsu, Ken

“…Intracellular circadian clocks, composed of clock genes that act in transcription-translation feedback loops, drive global rhythmic expression of the mammalian…”
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Personalized sleep and nutritional strategies to combat adverse effects of night shift work: a controlled intervention protocol by van der Rhee, Maaike, Oosterman, Johanneke E, Wopereis, Suzan, van der Horst, Gijsbertus T J, Chaves, Inês, Dollé, Martijn E T, Burdorf, Alex, van Kerkhof, Linda W M, der Holst, Heidi M Lammers-Van

“…Working during the night interferes with the timing of normal daily activities and is associated with an increased risk of chronic diseases. Under controlled…”
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Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock by Engelen, Erik, Janssens, Roel C, Yagita, Kazuhiro, Smits, Veronique A J, van der Horst, Gijsbertus T J, Tamanini, Filippo

“…The transcription/translation feedback loop-based molecular oscillator underlying the generation of circadian gene expression is preserved in almost all…”
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Phase Responses to Light Pulses in Mice Lacking Functional per or cry Genes by Spoelstra, Kamiel, Albrecht, Urs, van der Horst, Gijsbertus T. J., Brauer, Verena, Daan, Serge

“…The phase-resetting properties of the circadian system in mice with a functional deletion in mCry1, mCry2, mPer1, or mPer2 were studied in 2 experiments. In…”
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Circadian Behavioral Rhythms in Cry1/Cry2 Double-Deficient Mice Induced by Methamphetamine by Honma, Sato, Yasuda, Tsubura, Yasui, Akira, van der Horst, Gijsbertus T.J, Honma, Ken-ichi

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Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology by Jaarsma, Dick, van der Pluijm, Ingrid, de Waard, Monique C, Haasdijk, Elize D, Brandt, Renata, Vermeij, Marcel, Rijksen, Yvonne, Maas, Alex, van Steeg, Harry, Hoeijmakers, Jan H J, van der Horst, Gijsbertus T J

“…Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neuronal degeneration and whether defects in different repair…”
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Premature Aging in Mice Deficient in DNA Repair and Transcription by de Boer, Jan, Andressoo, Jaan Olle, de Wit, Jan, Huijmans, Jan, Beems, Rudolph B., van Steeg, Harry, Weeda, Geert, Gijsbertus T. J. van der Horst, van Leeuwen, Wibeke, Axel P. N. Themmen, Meradji, Morteza, Jan H. J. Hoeijmakers

“…One of the factors postulated to drive the aging process is the accumulation of DNA damage. Here, we provide strong support for this hypothesis by describing…”
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Optimization of irinotecan chronotherapy with P-glycoprotein inhibition by Filipski, Elisabeth, Berland, Elodie, Ozturk, Narin, Guettier, Catherine, van der Horst, Gijsbertus T.J., Lévi, Francis, Okyar, Alper

“…The relevance of P-glycoprotein (P-gp) for irinotecan chronopharmacology was investigated in female B6D2F1 mice. A three-fold 24h change in the mRNA expression…”
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A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage by OSTEROD, Marcel, LARSEN, Elisabeth, LE PAGE, Florence, HENGSTLER, Jan G, VAN DER HORST, Gijsbertus T. J, BOITEUX, Serge, KLUNGLAND, Arne, EPE, Bernd

“…The Cockayne syndrome B (CSB) gene product is involved in the repair of various types of base modifications in actively transcribed DNA sequences. To…”
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Disruption of clock gene expression in human colorectal liver metastases by Huisman, Sander A., Ahmadi, Ali R., IJzermans, Jan N. M., Verhoef, Cees, van der Horst, Gijsbertus T. J., de Bruin, Ron W. F.

“…The circadian timing system controls about 40 % of the transcriptome and is important in the regulation of a wide variety of biological processes including…”
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Identification of Cyclobutane Pyrimidine Dimer-Responsive Genes Using UVB-Irradiated Human Keratinocytes Transfected with In Vitro-Synthesized Photolyase mRNA by Boros, Gábor, Miko, Edit, Muramatsu, Hiromi, Weissman, Drew, Emri, Eszter, van der Horst, Gijsbertus T J, Szegedi, Andrea, Horkay, Irén, Emri, Gabriella, Karikó, Katalin, Remenyik, Éva

“…Major biological effects of UVB are attributed to cyclobutane pyrimidine dimers (CPDs), the most common photolesions formed on DNA. To investigate the…”
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Cryptochromes: Blue Light Photoreceptors in Plants and Animals by Chaves, Inês, Pokorny, Richard, Byrdin, Martin, Hoang, Nathalie, Ritz, Thorsten, Brettel, Klaus, Essen, Lars-Oliver, Horst, Gijsbertus T.J. van der, Batschauer, Alfred, Ahmad, Margaret

“…Cryptochromes are flavoprotein photoreceptors first identified in Arabidopsis thaliana, where they play key roles in growth and development. Subsequently…”
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