Search Results - "Van Den Steen, Philippe E."

Skeleton binding protein-1-mediated parasite sequestration inhibits spontaneous resolution of malaria-associated acute respiratory distress syndrome by Possemiers, Hendrik, Pham, Thao-Thy, Coens, Marion, Pollenus, Emilie, Knoops, Sofie, Noppen, Sam, Vandermosten, Leen, D'haese, Sigrid, Dillemans, Luna, Prenen, Fran, Schols, Dominique, Franke-Fayard, Blandine, Van den Steen, Philippe E

“…Malaria is a hazardous disease caused by Plasmodium parasites and often results in lethal complications, including malaria-associated acute respiratory…”
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Etiology of lactic acidosis in malaria by Possemiers, Hendrik, Vandermosten, Leen, Van den Steen, Philippe E

“…Lactic acidosis and hyperlactatemia are common metabolic disturbances in patients with severe malaria. Lactic acidosis causes physiological adverse effects,…”
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Endothelial Response to Glucocorticoids in Inflammatory Diseases by Zielińska, Karolina A, Van Moortel, Laura, Opdenakker, Ghislain, De Bosscher, Karolien, Van den Steen, Philippe E

“…The endothelium plays a crucial role in inflammation. A balanced control of inflammation requires the action of glucocorticoids (GCs), steroidal hormones with…”
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The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases by Cauwe, Bénédicte, Van den Steen, Philippe E, Opdenakker, Ghislain

“…Matrix metalloproteinases (MMPs) constitute a family of more than 20 endopeptidases. Identification of specific matrix and non-matrix components as MMP…”
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Single cell RNA sequencing reveals endothelial cell killing and resolution pathways in experimental malaria-associated acute respiratory distress syndrome by Pollenus, Emilie, Possemiers, Hendrik, Knoops, Sofie, Prenen, Fran, Vandermosten, Leen, Thienpont, Chloë, Abdurahiman, Saeed, Demeyer, Sofie, Cools, Jan, Matteoli, Gianluca, Vanoirbeek, Jeroen A J, Vande Velde, Greetje, Van den Steen, Philippe E

“…Plasmodium parasites cause malaria, a global health disease that is responsible for more than 200 million clinical cases and 600 000 deaths each year. Most…”
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Adrenal hormones mediate disease tolerance in malaria by Vandermosten, Leen, Pham, Thao-Thy, Knoops, Sofie, De Geest, Charlotte, Lays, Natacha, Van der Molen, Kristof, Kenyon, Christopher J., Verma, Manu, Chapman, Karen E., Schuit, Frans, De Bosscher, Karolien, Opdenakker, Ghislain, Van den Steen, Philippe E.

“…Malaria reduces host fitness and survival by pathogen-mediated damage and inflammation. Disease tolerance mechanisms counter these negative effects without…”
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Experimental malaria-associated acute kidney injury is independent of parasite sequestration and resolves upon antimalarial treatment by Possemiers, Hendrik, Pollenus, Emilie, Prenen, Fran, Knoops, Sofie, Koshy, Priyanka, Van den Steen, Philippe E.

“…Malaria remains a important global disease with more than 200 million cases and 600 000 deaths each year. Malaria-associated acute kidney injury (MAKI) may…”
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Absence of CCR2 Promotes Proliferation of Alveolar Macrophages That Control Lung Inflammation in Acute Respiratory Distress Syndrome in Mice by Oliveira, Vivian Louise Soares de, Pollenus, Emilie, Berghmans, Nele, Queiroz-Junior, Celso Martins, Blanter, Marfa, Mattos, Matheus Silvério, Teixeira, Mauro Martins, Proost, Paul, Van den Steen, Philippe E., Amaral, Flávio Almeida, Struyf, Sofie

“…Acute respiratory distress syndrome (ARDS) consists of uncontrolled inflammation that causes hypoxemia and reduced lung compliance. Since it is a complex…”
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Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade by Vandooren, Jennifer, Van den Steen, Philippe E, Opdenakker, Ghislain

“…Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-9, has grown exponentially in the decade 2003-2012. Structural…”
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Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins by Piccard, Helene, Van den Steen, Philippe E., Opdenakker, Ghislain

“…The heme‐binding hemopexin consists of two, four‐bladed propeller domains connected by a linker region. Hemopexin domains are found in different species on the…”
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A Multimodal Imaging-Supported Down Syndrome Mouse Model of RSV Infection by Tielemans, Birger, De Herdt, Lander, Pollenus, Emilie, Vanhulle, Emiel, Seldeslachts, Laura, Marain, Fopke, Belmans, Flore, Ahookhosh, Kaveh, Vanoirbeek, Jeroen, Vermeire, Kurt, Van den Steen, Philippe E, Vande Velde, Greetje

“…Individuals with Down syndrome (DS) are more prone to develop severe respiratory tract infections. Although a RSV infection has a high clinical impact and…”
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Release of endothelial activation markers in lungs of patients with malaria-associated acute respiratory distress syndrome by Pham, Thao-Thy, Punsawad, Chuchard, Glaharn, Supattra, De Meyer, Simon F, Viriyavejakul, Parnpen, Van den Steen, Philippe E

“…Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an understudied complication of malaria and is characterized by pulmonary inflammation and…”
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Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1 by Vandooren, Jennifer, Born, Benjamin, Solomonov, Inna, Zajac, Ewa, Saldova, Radka, Senske, Michael, Ugarte-Berzal, Estefanía, Martens, Erik, Van den Steen, Philippe E, Van Damme, Jo, Garcia-Pardo, Angeles, Froeyen, Matheus, Deryugina, Elena I, Quigley, James P, Moestrup, Søren K, Rudd, Pauline M, Sagi, Irit, Opdenakker, Ghislain

“…Gelatinase B/matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) cleaves many substrates and is produced by most cell types as a zymogen, proMMP-9, in complex…”
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Direct visualization of protease action on collagen triple helical structure by Rosenblum, Gabriel, Van den Steen, Philippe E, Cohen, Sidney R, Bitler, Arkady, Brand, David D, Opdenakker, Ghislain, Sagi, Irit

“…Enzymatic processing of extracellular matrix (ECM) macromolecules by matrix metalloproteases (MMPs) is crucial in mediating physiological and pathological cell…”
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The immunological balance between host and parasite in malaria by Deroost, Katrien, Pham, Thao-Thy, Opdenakker, Ghislain, Van den Steen, Philippe E.

“…Coevolution of humans and malaria parasites has generated an intricate balance between the immune system of the host and virulence factors of the parasite,…”
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The Immunopathology of Pulmonary Rejection after Murine Lung Transplantation by Kaes, Janne, Pollenus, Emilie, Hooft, Charlotte, Liu, Hengshuo, Aelbrecht, Celine, Cambier, Seppe, Jin, Xin, Van Slambrouck, Jan, Beeckmans, Hanne, Kerckhof, Pieterjan, Velde, Greetje Vande, Van Raemdonck, Dirk, Yildirim, Ali Önder, Van den Steen, Philippe E, Vos, Robin, Ceulemans, Laurens J, Vanaudenaerde, Bart M

“…To improve outcomes following lung transplantation, it is essential to understand the immunological mechanisms that result in chronic graft failure. The…”
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Zymography methods for visualizing hydrolytic enzymes by Vandooren, Jennifer, Geurts, Nathalie, Martens, Erik, Van den Steen, Philippe E, Opdenakker, Ghislain

“…A review of zymography techniques is presented. Zymography approaches yield valuable information about enzyme forms and localization of activity in tissues or…”
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Gelatinase B functions as regulator and effector in leukocyte biology by Opdenakker, Ghislain, Van den Steen, Philippe E., Dubois, Bénédicte, Nelissen, Inge, Van Coillie, Els, Masure, Stefan, Proost, Paul, Van Damme, Jo

“…Matrix metalloproteinases (MMPs) form a family of enzymes with major actions in the remodeling of extracellular matrix (ECM) components. Gelatinase B (MMP‐9)…”
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Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases by Opdenakker, Ghislain, Hu, Jialiang, Van den Steen, Philippe E, Sang, Qing-Xiang A

“…Matrix metalloproteinases (MMPs) have outgrown the field of extracellular-matrix biology and have progressed towards being important regulatory molecules in…”
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Natural haemozoin induces expression and release of human monocyte tissue inhibitor of metalloproteinase-1 by Polimeni, Manuela, Valente, Elena, Ulliers, Daniela, Opdenakker, Ghislain, Van den Steen, Philippe E, Giribaldi, Giuliana, Prato, Mauro

“…Recently matrix metalloproteinase-9 (MMP-9) and its endogenous inhibitor (tissue inhibitor of metalloproteinase-1, TIMP-1) have been implicated in complicated…”
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