Search Results - "Van Den Bosch, Aletta"

Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation by van den Bosch, Aletta M. R., van der Poel, Marlijn, Fransen, Nina L., Vincenten, Maria C. J., Bobeldijk, Anneleen M., Jongejan, Aldo, Engelenburg, Hendrik J., Moerland, Perry D., Smolders, Joost, Huitinga, Inge, Hamann, Jörg

“…Microglia nodules (HLA-DR + cell clusters) are associated with brain pathology. In this post-mortem study, we investigated whether they represent the first…”
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Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions by de Boer, Alyse, van den Bosch, Aletta M. R., Mekkes, Nienke J., Fransen, Nina L., Dagkesamanskaia, Ekaterina, Hoekstra, Eric, Hamann, Jörg, Smolders, Joost, Huitinga, Inge, Holtman, Inge R.

“…Multiple sclerosis (MS) is a heterogeneous neurological disorder with regards to clinical presentation and pathophysiology. Here, we investigated the…”
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Ultrastructural Axon–Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation by Bosch, Aletta M. R., Hümmert, Sophie, Steyer, Anna, Ruhwedel, Torben, Hamann, Jörg, Smolders, Joost, Nave, Klaus‐Armin, Stadelmann, Christine, Kole, Maarten H. P., Möbius, Wiebke, Huitinga, Inge

“…Objective Changes in the normal‐appearing white matter (NAWM) in multiple sclerosis (MS) may contribute to disease progression. Here, we systematically…”
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Resting-state fMRI reveals network disintegration during delirium by van Montfort, Simone J.T., van Dellen, Edwin, van den Bosch, Aletta M.R., Otte, Willem M., Schutte, Maya J.L., Choi, Soo-Hee, Chung, Tae-Sub, Kyeong, Sunghyon, Slooter, Arjen J.C., Kim, Jae-Jin

“…Delirium is characterized by inattention and other cognitive deficits, symptoms that have been associated with disturbed interactions between remote brain…”
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Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73 by Jarvis, Lorna B., Rainbow, Daniel B., Coppard, Valerie, Howlett, Sarah K., Georgieva, Zoya, Davies, Jessica L., Mullay, Harpreet Kaur, Hester, Joanna, Ashmore, Tom, Van Den Bosch, Aletta, Grist, James T., Coles, Alasdair J., Mousa, Hani S., Pluchino, Stefano, Mahbubani, Krishnaa T., Griffin, Julian L., Saeb-Parsy, Kourosh, Issa, Fadi, Peruzzotti-Jametti, Luca, Wicker, Linda S., Jones, Joanne L.

“…The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell…”
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White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue‐resident memory T cells by Hsiao, Cheng‐Chih, Fransen, Nina L., van den Bosch, Aletta M.R., Brandwijk, Kim I.M., Huitinga, Inge, Hamann, Jörg, Smolders, Joost

“…Brain CD8+CD69+ tissue‐resident memory T (TRM) cells comprise a CD20dim subset, which is proportionally larger in CD103‐negative TRM cells. In multiple…”
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White matter lesions in multiple sclerosis are enriched for CD20 dim CD8 + tissue-resident memory T cells by Hsiao, Cheng-Chih, Fransen, Nina L, van den Bosch, Aletta M R, Brandwijk, Kim I M, Huitinga, Inge, Hamann, Jörg, Smolders, Joost

“…Brain CD8 CD69 tissue-resident memory T (T ) cells comprise a CD20 subset, which is proportionally larger in CD103-negative T cells. In multiple sclerosis (MS)…”
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Cortical CD200–CD200R and CD47–SIRPα expression is associated with multiple sclerosis pathology by van den Bosch, Aletta M R, Wever, Dennis, Schonewille, Pleun, Schuller, Sabine L, Smolders, Joost, Hamann, Jörg, Huitinga, Inge

“…Abstract Control of microglia activity through CD200–CD200R and CD47–SIRPα interactions has been implicated in brain homeostasis. Here, we assessed CD200,…”
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Neural stem cells traffic functional mitochondria via extracellular vesicles by Peruzzotti-Jametti, Luca, Bernstock, Joshua D, Willis, Cory M, Manferrari, Giulia, Rogall, Rebecca, Fernandez-Vizarra, Erika, Williamson, James C, Braga, Alice, van den Bosch, Aletta, Leonardi, Tommaso, Krzak, Grzegorz, Kittel, Ágnes, Benincá, Cristiane, Vicario, Nunzio, Tan, Sisareuth, Bastos, Carlos, Bicci, Iacopo, Iraci, Nunzio, Smith, Jayden A, Peacock, Ben, Muller, Karin H, Lehner, Paul J, Buzas, Edit Iren, Faria, Nuno, Zeviani, Massimo, Frezza, Christian, Brisson, Alain, Matheson, Nicholas J, Viscomi, Carlo, Pluchino, Stefano

“…Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases. Although the replacement of lost endogenous…”
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Neurofilament Light Chain Levels in Multiple Sclerosis Correlate With Lesions Containing Foamy Macrophages and With Acute Axonal Damage by van den Bosch, Aletta, Fransen, Nina, Mason, Matthew, Rozemuller, Annemieke Johanna, Teunissen, Charlotte, Smolders, Joost, Huitinga, Inge

“…To investigate whether white matter lesion activity, acute axonal damage, and axonal density in MS associate with CSF neurofilament light chain (NfL) levels…”
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SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke by Bernstock, Joshua D., Peruzzotti-Jametti, Luca, Leonardi, Tommaso, Vicario, Nunzio, Ye, Daniel, Lee, Yang-ja, Maric, Dragan, Johnson, Kory R., Mou, Yongshan, Van Den Bosch, Aletta, Winterbone, Mark, Friedman, Gregory K., Franklin, Robin J.M., Hallenbeck, John M., Pluchino, Stefano

“…Neural stem cell (NSC)-based therapies hold great promise for treating diseases of the central nervous system (CNS). However, several fundamental problems…”
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SUMOylation promotes survival and integration of neural stem cell grafts in ischemic strokeResearch in context by Joshua D. Bernstock, Luca Peruzzotti-Jametti, Tommaso Leonardi, Nunzio Vicario, Daniel Ye, Yang-ja Lee, Dragan Maric, Kory R. Johnson, Yongshan Mou, Aletta Van Den Bosch, Mark Winterbone, Gregory K. Friedman, Robin J.M. Franklin, John M. Hallenbeck, Stefano Pluchino

“…Background: Neural stem cell (NSC)-based therapies hold great promise for treating diseases of the central nervous system (CNS). However, several fundamental…”
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