Search Results - "Van Cruchten, Steven"

A Medium-Throughput System for In Vitro Oxidative Stress Assessment in IPEC-J2 Cells by Ayuso, Miriam, Van Cruchten, Steven, Van Ginneken, Chris

“…The feed industry continuously seeks new molecules with antioxidant capacity since oxidative stress plays a key role in intestinal health. To improve screening…”
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Xenobiotic metabolism in the zebrafish: a review of the spatiotemporal distribution, modulation and activity of Cytochrome P450 families 1 to 3 by Saad, Moayad, Cavanaugh, Kate, Verbueken, Evy, Pype, Casper, Casteleyn, Christophe, Ginneken, Chris Van, Cruchten, Steven Van

“…The zebrafish (Danio rerio) has been increasingly explored in pharmaceutical research as a promising alternative model for toxicological screens. This…”
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Evaluating Complex Mixtures in the Zebrafish Embryo by Reconstituting Field Water Samples: A Metal Pollution Case Study by Michiels, Ellen D G, Vergauwen, Lucia, Hagenaars, An, Fransen, Erik, Dongen, Stefan Van, Van Cruchten, Steven J, Bervoets, Lieven, Knapen, Dries

“…Accurately assessing the toxicity of complex, environmentally relevant mixtures remains an important challenge in ecotoxicology. The goal was to identify…”
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Developmental Toxicity and Biotransformation of Two Anti-Epileptics in Zebrafish Embryos and Early Larvae by Bars, Chloé, Hoyberghs, Jente, Valenzuela, Allan, Buyssens, Laura, Ayuso, Miriam, Van Ginneken, Chris, Labro, Alain J, Foubert, Kenn, Van Cruchten, Steven J

“…The zebrafish ( ) embryo is gaining interest as a bridging tool between in-vitro and in-vivo developmental toxicity studies. However, cytochrome P450…”
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In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development by Verbueken, Evy, Alsop, Derek, Saad, Moayad A, Pype, Casper, Van Peer, Els M, Casteleyn, Christophe R, Van Ginneken, Chris J, Wilson, Joanna, Van Cruchten, Steven J

“…At present, the zebrafish embryo is increasingly used as an alternative animal model to screen for developmental toxicity after exposure to xenobiotics. Since…”
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Gene transcription ontogeny of hypothalamic-pituitary-thyroid axis development in early-life stage fathead minnow and zebrafish by Vergauwen, Lucia, Cavallin, Jenna E., Ankley, Gerald T., Bars, Chloé, Gabriëls, Isabelle J., Michiels, Ellen D.G., Fitzpatrick, Krysta R., Periz-Stanacev, Jelena, Randolph, Eric C., Robinson, Serina L., Saari, Travis W., Schroeder, Anthony L., Stinckens, Evelyn, Swintek, Joe, Van Cruchten, Steven J., Verbueken, Evy, Villeneuve, Daniel L., Knapen, Dries

“…[Display omitted] •Control fish were sampled at 25 time points covering embryo-larval development.•Transcript levels of 12 thyroid-related genes were…”
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Incubation at 32.5°C and above causes malformations in the zebrafish embryo by Pype, Casper, Verbueken, Evy, Saad, Moayad A., Casteleyn, Christophe R., Van Ginneken, Chris J., Knapen, Dries, Van Cruchten, Steven J.

“…Zebrafish embryos are increasingly used for developmental toxicity screening of candidate drugs and are occasionally co-incubated with a metabolic activation…”
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From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development by Verbueken, Evy, Bars, Chloé, Ball, Jonathan S, Periz-Stanacev, Jelena, Marei, Waleed F A, Tochwin, Anna, Gabriëls, Isabelle J, Michiels, Ellen D G, Stinckens, Evelyn, Vergauwen, Lucia, Knapen, Dries, Van Ginneken, Chris J, Van Cruchten, Steven J

“…The zebrafish ( ) embryo is currently explored as an alternative for developmental toxicity testing. As maternal metabolism is lacking in this model, knowledge…”
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Use of Zebrafish in Drug Discovery Toxicology by Cassar, Steven, Adatto, Isaac, Freeman, Jennifer L, Gamse, Joshua T, Iturria, Iñaki, Lawrence, Christian, Muriana, Arantza, Peterson, Randall T, Van Cruchten, Steven, Zon, Leonard I

“…Unpredicted human safety events in clinical trials for new drugs are costly in terms of human health and money. The drug discovery industry attempts to…”
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Preweaning performance in intrauterine growth‐restricted piglets: Characteristics and interventions by Van Ginneken, Chris, Ayuso, Miriam, Van Bockstal, Lieselotte, Van Cruchten, Steven

“…Intrauterine growth restriction (IUGR) is frequently observed in pig production, especially when using highly prolific sows. IUGR piglets are born with low…”
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Artificial rearing influences the morphology,permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets by Vergauwen, Hans, Degroote, Jeroen, Prims, Sara, Wang, Wei, Fransen, Erik, De Smet, Stefaan, Casteleyn, Christophe, Van Cruchten, Steven, Michiels, Joris, Van Ginneken, Chris

“…Background： In this study the physiological implications of artificial rearing were investigated. Low（LBW） and normal birth weight（NBW） piglets were compared…”
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A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates by Smits, Anne, Annaert, Pieter, Van Cruchten, Steven, Allegaert, Karel

“…Therapeutic hypothermia (TH) is standard treatment for neonates (≥36 weeks) with perinatal asphyxia (PA) and hypoxic-ischemic encephalopathy. TH reduces…”
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Cell migration and proliferation capacity of IPEC-J2 cells after short-chain fatty acid exposure by Van Bockstal, Lieselotte, Prims, Sara, Van Cruchten, Steven, Ayuso, Miriam, Che, Lianqiang, Van Ginneken, Chris

“…Novel antimicrobial strategies are necessary to tackle using antibiotics during the suckling and weaning period of piglets, often characterized by E…”
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DMSO Concentrations up to 1% are Safe to be Used in the Zebrafish Embryo Developmental Toxicity Assay by Hoyberghs, Jente, Bars, Chloé, Ayuso, Miriam, Van Ginneken, Chris, Foubert, Kenn, Van Cruchten, Steven

“…Dimethyl sulfoxide (DMSO) is a popular solvent for developmental toxicity testing of chemicals and pharmaceuticals in zebrafish embryos. In general, it is…”
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Does intrauterine crowding affect locomotor development? A comparative study of motor performance, neuromotor maturation and gait variability among piglets that differ in birth weight and vitality by Vanden Hole, Charlotte, Aerts, Peter, Prims, Sara, Ayuso, Miriam, Van Cruchten, Steven, Van Ginneken, Chris

“…In polytocous species, such as pigs, the growth of an individual fetus is affected by competition from its littermates and the sow. This intrauterine…”
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Chronic exposure to multiple stressors alters the salivary proteome of piglets by Prims, Sara, Van Ostade, Xaveer, Ayuso, Miriam, Dom, Martin, Van Raemdonck, Geert, Van Cruchten, Steven, Casteleyn, Christophe, Van Ginneken, Chris

“…Monitoring chronic stress in pigs is not only essential in view of animal welfare but is also important for the farmer, given that stress influences the…”
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Effects of hypothermia and hypoxia on cytochrome P450‐mediated drug metabolism in neonatal Göttingen minipigs by Stroe, Marina‐Stefania, De Clerck, Laura, Dhaenens, Maarten, Dennis, Rachel Siân, Deforce, Dieter, Carpentier, Sebastien, Annaert, Pieter, Leys, Karen, Smits, Anne, Allegaert, Karel, Van Ginneken, Chris, Van Cruchten, Steven

“…Asphyxiated neonates often undergo therapeutic hypothermia (TH) to reduce morbidity and mortality. As perinatal asphyxia and TH impact neonatal physiology,…”
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Thriving or Striving: Comparing Intra-Uterine Growth Restricted, Low Birth Weight and Normal Birth Weight Piglets within the First 24 Hours by Loyens, Marlotte, Van Bockstal, Lieselotte, Prims, Sara, Van Cruchten, Steven, Van Ginneken, Chris

“…This observational study explored the early-life challenges of intra-uterine growth restricted (IUGR), low birth body weight (LBW), and normal birth body…”
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How does intrauterine crowding affect locomotor performance in newborn pigs? A study of force generating capacity and muscle composition of the hind limb by Vanden Hole, Charlotte, Cleuren, Silke, Van Ginneken, Chris, Prims, Sara, Ayuso, Miriam, Van Cruchten, Steven, Aerts, Peter

“…Intrauterine crowding (IUC) considerably influences postnatal traits in a polytocous species such as the pig. Previously, our group described how IUC affects…”
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Does intrauterine crowding affect the force generating capacity and muscle composition of the piglet front limb? by Vanden Hole, Charlotte, Van Ginneken, Chris, Prims, Sara, Ayuso, Miriam, Van Cruchten, Steven, Aerts, Peter

“…In the pig, intrauterine competition (IUC) greatly affects postnatal traits, such as birth weight, but also locomotor capacities. In a previous study, our…”
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