Search Results - "Van Buuren, Nicholas"

Transmission genetics of drug-resistant hepatitis C virus by van Buuren, Nicholas, Tellinghuisen, Timothy L, Richardson, Christopher D, Kirkegaard, Karla

“…Antiviral development is plagued by drug resistance and genetic barriers to resistance are needed. For HIV and hepatitis C virus (HCV), combination therapy has…”
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A selectable and excisable marker system for the rapid creation of recombinant poxviruses by Rintoul, Julia L, Wang, Jiahu, Gammon, Don B, van Buuren, Nicholas J, Garson, Kenneth, Jardine, Karen, Barry, Michele, Evans, David H, Bell, John C

“…Genetic manipulation of poxvirus genomes through attenuation, or insertion of therapeutic genes has led to a number of vector candidates for the treatment of a…”
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Ectromelia virus encodes a family of Ankyrin/F-box proteins that regulate NFκB by Burles, Kristin, van Buuren, Nicholas, Barry, Michele

“…Abstract A notable feature of poxviruses is their ability to inhibit the antiviral response, including the nuclear factor kappa B (NFκB) pathway. NFκB is a…”
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The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites by Neufeldt, Christopher J, Joyce, Michael A, Van Buuren, Nicholas, Levin, Aviad, Kirkegaard, Karla, Gale, Jr, Michael, Tyrrell, D Lorne J, Wozniak, Richard W

“…Hepatitis C virus (HCV) is a positive-strand RNA virus of the Flaviviridae family and a major cause of liver disease worldwide. HCV replicates in the…”
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My Cousin, My Enemy: quasispecies suppression of drug resistance by Kirkegaard, Karla, van Buuren, Nicholas J., Mateo, Roberto

“…•Drug targets can be chosen so that drug susceptibility is genetically dominant.•Dominant drug targets prevent the selection of drug-resistant…”
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An RNA-centric dissection of host complexes controlling flavivirus infection by Ooi, Yaw Shin, Majzoub, Karim, Flynn, Ryan A., Mata, Miguel A., Diep, Jonathan, Li, Jason Kenichi, van Buuren, Nicholas, Rumachik, Neil, Johnson, Alex G., Puschnik, Andreas S., Marceau, Caleb D., Mlera, Luwanika, Grabowski, Jeffrey M., Kirkegaard, Karla, Bloom, Marshall E., Sarnow, Peter, Bertozzi, Carolyn R., Carette, Jan E.

“…Flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), cause severe human disease. Co-opting cellular factors for viral translation and viral…”
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Detection and Differentiation of Multiple Viral RNAs Using Branched DNA FISH Coupled to Confocal Microscopy and Flow Cytometry by van Buuren, Nicholas, Kirkegaard, Karla

“…Due to the exceptionally high mutation rates of RNA-dependent RNA polymerases, infectious RNA viruses generate extensive sequence diversity, leading to some of…”
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Targeted long-read sequencing reveals clonally expanded HBV-associated chromosomal translocations in patients with chronic hepatitis B by van Buuren, Nicholas, Ramirez, Ricardo, Soulette, Cameron, Suri, Vithika, Han, Dong, May, Lindsey, Turner, Scott, Parvangada, P.C., Martin, Ross, Chan, Henry L.Y., Marcellin, Patrick, Buti, Maria, Bui, Nam, Bhardwaj, Neeru, Gaggar, Anuj, Li, Li, Mo, Hongmei, Feierbach, Becket

“…HBV infects over 257 million people worldwide and is associated with the development of hepatocellular carcinoma (HCC). Integration of HBV DNA into the host…”
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EVM005: an ectromelia-encoded protein with dual roles in NF-κB inhibition and virulence by van Buuren, Nicholas, Burles, Kristin, Schriewer, Jill, Mehta, Ninad, Parker, Scott, Buller, R Mark, Barry, Michele

“…Poxviruses contain large dsDNA genomes encoding numerous open reading frames that manipulate cellular signalling pathways and interfere with the host immune…”
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Intrahepatic quantification of HBV antigens in chronic hepatitis B reveals heterogeneity and treatment-mediated reductions in HBV core-positive cells by Aggarwal, Abhishek, Odorizzi, Pamela M., Brodbeck, Jens, van Buuren, Nicholas, Moon, Christina, Chang, Silvia, Adona, MaryVic, Suthram, Silpa, Suri, Vithika, Trowe, Torsten, Turner, Scott, Marcellin, Patrick, Buti, Maria, Gaggar, Anuj, Fletcher, Simon P., Diehl, Lauri, Feierbach, Becket, Balsitis, Scott

“…Patterns of liver HBV antigen expression have been described but not quantified at single-cell resolution. We applied quantitative techniques to liver biopsies…”
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The 5th Canadian Symposium on Hepatitis C Virus: We Are Not Done Yet—Remaining Challenges in Hepatitis C by Klein, Marina B., Sagan, Selena M., Wilson, Joyce A., Marshall, Alison, MacParland, Sonya A., Krajden, Mel, King, Alexandra, Grebely, Jason, Fradette, Lorraine, van Buuren, Nicholas, Saeed, Sahar

“…Hepatitis C virus (HCV) affects approximately 268,000 Canadians and results in more years of life lost than any other infectious disease in the country. Both…”
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Poxvirus exploitation of the ubiquitin-proteasome system by Barry, Michele, van Buuren, Nicholas, Burles, Kristin, Mottet, Kelly, Wang, Qian, Teale, Alastair

“…Ubiquitination plays a critical role in many cellular processes. A growing number of viruses have evolved strategies to exploit the ubiquitin-proteasome…”
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Multi-omics analysis of human livers reveals variation in intrahepatic inflammation across chronic hepatitis B infection phases by Montanari, Noé Axel, Ramirez, Ricardo, Aggarwal, Abhishek, Buuren, Nicholas Van, Doukas, Michael, Moon, Christina, Turner, Scott, Diehl, Lauri, Li, Li, Debes, Jose, Feierbach, Becket, Boonstra, Andre

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Intrahepatic transcriptional profiling demonstrates preclinical models of chronic hepatitis B resemble different stages of natural history in humans by Ramirez, Ricardo, Hyrina, Anastasia, Beran, Rudolf, Daffis, Stephane, Gilmore, Sarah, Kang, Don, Montanari, Noé Axel, Van Buuren, Nicholas, Li, Li, Burdette, Dara, Feierbach, Becket, Boonstra, Andre, Fletcher, Simon

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Targeted Long-Read Sequencing Reveals Comprehensive Architecture, Burden, and Transcriptional Signatures from Hepatitis B Virus-Associated Integrations and Translocations in Hepatocellular Carcinoma Cell Lines by Ramirez, Ricardo, van Buuren, Nicholas, Gamelin, Lindsay, Soulette, Cameron, May, Lindsey, Han, Dong, Yu, Mei, Choy, Regina, Cheng, Guofeng, Bhardwaj, Neeru, Chiu, Joy, Muench, Robert C, Delaney, 4th, William E, Mo, Hongmei, Feierbach, Becket, Li, Li

“…Hepatitis B virus (HBV) can integrate into the chromosomes of infected hepatocytes, creating potentially oncogenic lesions that can lead to hepatocellular…”
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331 – The Long Non-Coding Rna, Ifng-As1/Nest, is Associated with IBD and Potentiates a Pro-Inflammatory Signaling Cascade by Rankin, Carl R., Rowe, Lorraine, van Buuren, Nicholas, Kirkegaard, Karla, Padua, David M.

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SAT379 - Delineating HBV transcripts from integrated viral DNA using target enrichment and long read sequencing by Van Buuren, Nicholas, Ramirez, Ricardo, Xu, Simin, Gamelin, Lindsay, Muench, Robert, Mo, Hongmei, Li, Li, Feierbach, Becket

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Delineating HBV transcripts from integrated viral DNA using target enrichment and long read sequencing by Van Buuren, Nicholas, Ramirez, Ricardo, Xu, Simin, Gamelin, Lindsay, Muench, Robert, Mo, Hongmei, Li, Li, Feierbach, Becket

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P151 THE LONG NON-CODING RNA, IFNG-AS1/NEST, IS ASSOCIATED WITH IBD AND DRIVES A PRO-INFLAMMATORY SIGNALING CASCADE by Rankin, Carl R., Van Buuren, Nicholas, Kirkegaard, Karla, Rowe, Lorraine, Pothoulakis, Charalabos, Padua, David M.

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Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression by Gane, Edward J., Dunbar, P. Rod, Brooks, Anna E., Zhang, Fangqiu, Chen, Diana, Wallin, Jeffrey J., van Buuren, Nicholas, Arora, Priyanka, Fletcher, Simon P., Tan, Susanna K., Yang, Jenny C., Gaggar, Anuj, Kottilil, Shyamasundaran, Tang, Lydia

“…Selgantolimod (GS-9688) is a Toll-like receptor 8 (TLR8) agonist that suppresses HBV in vitro. In a phase II study, we evaluated the safety and efficacy of…”
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