Search Results - "Van Besien, Herman"

Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma by Giulino-Roth, Lisa, van Besien, Herman J, Dalton, Tanner, Totonchy, Jennifer E, Rodina, Anna, Taldone, Tony, Bolaender, Alexander, Erdjument-Bromage, Hediye, Sadek, Jouliana, Chadburn, Amy, Barth, Matthew J, Dela Cruz, Filemon S, Rainey, Allison, Kung, Andrew L, Chiosis, Gabriela, Cesarman, Ethel

“…Hsp90 is a molecular chaperone that protects proteins, including oncogenic signaling complexes, from proteolytic degradation. PU-H71 is a next-generation Hsp90…”
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Analysis of the rotational structure in the high-resolution infrared spectra of trans-hexatriene-2-d1 and -3-d1 by Craig, Norman C., Chen, Yihui, Besien, Herman van, Blake, Thomas A.

“…[Display omitted] •trans-Hexatriene-2-d1 and -3-d1 were synthesized.•Anharmonic vibration frequencies were computed for the out-of-plane modes.•High-resolution…”
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Microwave Spectra of the Deuterium Isotopologues of cis-Hexatriene and a Semiexperimental Equilibrium Structure by Craig, Norman C, Chen, Yihui, Fuson, Hannah A, Tian, Hengfeng, van Besien, Herman, Conrad, Andrew R, Tubergen, Michael J, Rudolph, Heinz Dieter, Demaison, Jean

“…Microwave transitions and ground state rotational constants are reported for five newly synthesized deuterium isotopologues of cis-1,3,5-hexatriene (cHTE)…”
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Targeting Metabolic Vulnerabilities in Primary Effusion Lymphoma Using the Novel Nucleoside Analog 6-Eti by Sadek, Jouliana, Krumsiek, Jan, Zhang, Tuo, Coan, Barbara, Ibañez de Garayo, Maite, Dalton, Tanner, Yahyaei, Sara, Van Besien, Herman, Cesarman, Ethel

“…Although nucleoside analogues have been used effectively in the clinic for the treatment of a wide range of hematological malignancies, lack of response to…”
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Combined EZH2 and BCL2 Inhibitors As Precision Therapy for Genetically Defined DLBCL Subtypes by Gibbs, Destini, Van Besien, Herman, Regan, Stephenson, Singh, Ankur, Teater, Matthew, Cesarman, Ethel, Melnick, Ari, Roth, Lisa Giulino

“…DLCBL has recently been classified into genetically defined subtypes based on groupings of particular genetic lesions (Chapuy et al, Nat Med 2018; Schmitz et…”
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Arrhythmic Complications Associated with Cancer Therapies by Pothineni, Naga Venkata K., Van Besien, Herman, Fradley, Michael G.

“…Over the last several decades, advancements in cancer screening and treatment have significantly improved cancer mortality and overall quality of life…”
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Targeting the Hsp90 Oncoproteome in Burkitt Lymphoma by Giulino Roth, Lisa, van Besien, Herman, Rodina, Anna, Taldone, Tony, Erdjument-Bromage, Hediye, Barth, Matthew J., Chiosis, Gabriela, Cesarman, Ethel

“…Introduction: Novel therapies are urgently needed in pediatric Burkitt lymphoma (pBL) where the survival for relapsed disease is less than 20%. Heat shock…”
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Combined EZH2 and Bcl-2 inhibitors as precision therapy for genetically defined DLBCL subtypes by Scholze, Hanna, Stephenson, Regan E., Reynolds, Raymond, Shah, Shivem, Puri, Rishi, Butler, Scott D., Trujillo-Alonso, Vicenta, Teater, Matthew R., van Besien, Herman, Gibbs-Curtis, Destini, Ueno, Hideki, Parvin, Salma, Letai, Anthony, Mathew, Susan, Singh, Ankur, Cesarman, Ethel, Melnick, Ari, Giulino-Roth, Lisa

“…Molecular alterations in the histone methyltransferase EZH2 and the antiapoptotic protein Bcl-2 frequently co-occur in diffuse large B-cell lymphoma (DLBCL)…”
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Long Term Neurologic Outcomes for Patients Receiving CAR-T Therapy for Non-Hodgkin’s Lymphoma Who Developed Severe Neurotoxicity by van Besien, Herman, Porter, David L., Nasta, Sunita D., Svoboda, Jakub, Barta, Stefan K., Schuster, Stephen J., Chong, Elise, Hollander, Lauren, Kucharczuk, Colleen, Carulli, Alison, Stadtmauer, Edward A., Garfall, Alfred L., Frey, Noelle V., Landsburg, Daniel J.

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260 - Long Term Neurologic Outcomes for Patients Receiving CAR-T Therapy for Non-Hodgkin’s Lymphoma Who Developed Severe Neurotoxicity by van Besien, Herman, Porter, David L., Nasta, Sunita D., Svoboda, Jakub, Barta, Stefan K., Schuster, Stephen J., Chong, Elise, Hollander, Lauren, Kucharczuk, Colleen, Carulli, Alison, Stadtmauer, Edward A., Garfall, Alfred L., Frey, Noelle V., Landsburg, Daniel J.

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Antileukemic properties of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors by van Besien, Herman, Sassano, Antonella, Altman, Jessica K., Platanias, Leonidas C.

“…Abstract Statins are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors that act on the mevalonate pathway and inhibit synthesis of…”
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Analysis of the rotational structure in the high-resolution infrared spectra of trans-hexatriene-2-d1 and -3-d1 by Craig, Norman C., Chen, Yihui, Besien, Herman van, Blake, Thomas A.

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Abstract PO-53: Combined EZH2 and BCL2 inhibitors as precision therapy for genetically defined DLBCL subtypes by Scholze, Hanna, Stephenson, Regan E., Reynolds, Raymond, Shah, Shivem, Puri, Rishi, Teater, Matthew R., van Besien, Herman, Gibbs-Curtis, Destini, Ueno, Hideki, Parvin, Salma, Letai, Anthony G., Mathew, Susan, Singh, Ankur, Cesarman, Ethel, Melnick, Ari, Giulino-Roth, Lisa

“…Abstract Molecular alterations in the histone methyltransferase EZH2 and the antiapoptotic protein BCL2 frequently co-occur in diffuse large B-cell lymphoma…”
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