Search Results - "Van Amerongen, P"

Electric cell-substrate impedance sensing for the quantification of endothelial proliferation, barrier function, and motility by Szulcek, Robert, Bogaard, Harm Jan, van Nieuw Amerongen, Geerten P

“…Electric Cell-substrate Impedance Sensing (ECIS) is an in vitro impedance measuring system to quantify the behavior of cells within adherent cell layers. To…”
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Transient Intervals of Hyper-Gravity Enhance Endothelial Barrier Integrity: Impact of Mechanical and Gravitational Forces Measured Electrically by Szulcek, Robert, van Bezu, Jan, Boonstra, Johannes, van Loon, Jack J W A, van Nieuw Amerongen, Geerten P

“…Endothelial cells (EC) guard vascular functions by forming a dynamic barrier throughout the vascular system that sensitively adapts to 'classical'…”
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Using cultured endothelial cells to study endothelial barrier dysfunction: Challenges and opportunities by Aman, Jurjan, Weijers, Ester M, van Nieuw Amerongen, Geerten P, Malik, Asrar B, van Hinsbergh, Victor W M

“…Despite considerable progress in the understanding of endothelial barrier regulation and the identification of approaches that have the potential to improve…”
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Targeting Abl Kinases to Regulate Vascular Leak During Sepsis and Acute Respiratory Distress Syndrome by Rizzo, Alicia N, Aman, Jurjan, van Nieuw Amerongen, Geerten P, Dudek, Steven M

“…The vascular endothelium separates circulating fluid and inflammatory cells from the surrounding tissues. Vascular leak occurs in response to wide-spread…”
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Effective Treatment of Edema and Endothelial Barrier Dysfunction With Imatinib by AMAN, Jurjan, BEZU, Jan Van, DAMANAFSHAN, Amin, HUVENEERS, Stephan, ERINGA, Etto C, VOGEL, Steven M, JOHAN GROENEVELD, A. B, VONK NOORDEGRAAF, Anton, HINSBERGH, Victor W. M. Van, NIEUW AMERONGEN, Geerten P. Van

“…Tissue edema and endothelial barrier dysfunction as observed in sepsis and acute lung injury carry high morbidity and mortality, but currently lack specific…”
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Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces by Krishnan, Ramaswamy, Klumpers, Darinka D, Park, Chan Y, Rajendran, Kavitha, Trepat, Xavier, van Bezu, Jan, van Hinsbergh, Victor W M, Carman, Christopher V, Brain, Joseph D, Fredberg, Jeffrey J, Butler, James P, van Nieuw Amerongen, Geerten P

“…A hallmark of many, sometimes life-threatening, inflammatory diseases and disorders is vascular leakage. The extent and severity of vascular leakage is broadly…”
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Rac Attack: Modulation of the Small GTPase Rac in Inflammatory Bowel Disease and Thiopurine Therapy by Seinen, Margien L., van Nieuw Amerongen, Geerten P., de Boer, Nanne K. H., van Bodegraven, Adriaan A.

“…The incidence and prevalence of inflammatory bowel disease (IBD) are increasing. Although the etiology of IBD is unknown, it is thought that genetically…”
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Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction by Daneshjou, Nazila, Sieracki, Nathan, van Nieuw Amerongen, Geerten P, Conway, Daniel E, Schwartz, Martin A, Komarova, Yulia A, Malik, Asrar B

“…The role of the RhoGTPase Rac1 in stabilizing mature endothelial adherens junctions (AJs) is not well understood. In this paper, using a photoactivatable probe…”
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Driving Rho GTPase activity in endothelial cells regulates barrier integrity by Beckers, Cora M L, van Hinsbergh, Victor W M, van Nieuw Amerongen, Geerten P

“…In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42 has been developed from regulatory proteins that regulate specific actin…”
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Prediction of Morbidity and Mortality After Esophagectomy: A Systematic Review by van Nieuw Amerongen, M. P., de Grooth, H. J., Veerman, G. L., Ziesemer, K. A., van Berge Henegouwen, M. I., Tuinman, P. R.

“…Background Esophagectomy for esophageal cancer has a complication rate of up to 60%. Prediction models could be helpful to preoperatively estimate which…”
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Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition by Chen, Zhenlong, Bakhshi, Farnaz R, Shajahan, Ayesha N, Sharma, Tiffany, Mao, Mao, Trane, Andy, Bernatchez, Pascal, van Nieuw Amerongen, Geerten P, Bonini, Marcelo G, Skidgel, Randal A, Malik, Asrar B, Minshall, Richard D

“…Endothelial nitric oxide synthase (eNOS)-mediated NO production plays a critical role in the regulation of vascular function and pathophysiology. Caveolin-1…”
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Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells by van der Heijden, Melanie, van Nieuw Amerongen, Geerten P, van Bezu, Jan, Paul, Marinus A, Groeneveld, A B Johan, van Hinsbergh, Victor W M

“…Angiopoietin-2 (Ang-2) is associated with lung injury in ALI/ARDS. As endothelial activation by thrombin plays a role in the permeability of acute lung injury…”
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A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability by Amado-Azevedo, Joana, de Menezes, Renee X, van Nieuw Amerongen, Geerten P, van Hinsbergh, Victor W M, Hordijk, Peter L

“…Thrombin and other inflammatory mediators may induce vascular permeability through the disruption of adherens junctions between adjacent endothelial cells. If…”
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Traction force dynamics predict gap formation in activated endothelium by Valent, Erik T., van Nieuw Amerongen, Geerten P., van Hinsbergh, Victor W.M., Hordijk, Peter L.

“…In many pathological conditions the endothelium becomes activated and dysfunctional, resulting in hyperpermeability and plasma leakage. No specific therapies…”
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Activation of RhoA by Thrombin in Endothelial Hyperpermeability: Role of Rho Kinase and Protein Tyrosine Kinases by Amerongen, Geerten P. van Nieuw, Delft, Sanne van, Vermeer, Mario A, Collard, John G, van Hinsbergh, Victor W. M

“…Endothelial cells (ECs) actively regulate the extravasation of blood constituents. On stimulation by vasoactive agents and thrombin, ECs change their…”
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Regulation of the endothelial barrier function: a filum granum of cellular forces, Rho-GTPase signaling and microenvironment by Amado-Azevedo, Joana, Valent, Erik T, Van Nieuw Amerongen, Geerten P

“…Although the endothelium is an extremely thin single-cell layer, it performs exceedingly well in preventing blood fluids from leaking into the surrounding…”
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Reversal of vascular leak with imatinib by Aman, Jurjan, Peters, Mike J L, Weenink, Carla, van Nieuw Amerongen, Geerten P, Vonk Noordegraaf, Anton

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A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity by Amado-Azevedo, J., Reinhard, N. R., van Bezu, J., de Menezes, R. X., van Beusechem, V. W., van Nieuw Amerongen, G. P., van Hinsbergh, V. W. M., Hordijk, P. L.

“…Endothelial barrier function is carefully controlled to protect tissues from edema and damage inflicted by extravasated leukocytes. RhoGTPases, in conjunction…”
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Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients by van der Heijden, M, van Nieuw Amerongen, G P, Koolwijk, P, van Hinsbergh, V W M, Groeneveld, A B J

“…Angiopoietin-2 and vascular endothelial growth factor (VEGF) may impair vascular barrier function while angiopoietin-1 may protect it. It was hypothesised that…”
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Transient and Prolonged Increase in Endothelial Permeability Induced by Histamine and Thrombin: Role of Protein Kinases, Calcium, and RhoA by van Nieuw Amerongen, Geerten P, Draijer, Richard, Vermeer, Mario A, van Hinsbergh, Victor W.M

“…In the present study, we differentiated between short- and long-term effects of vasoactive compounds on human endothelial permeability in an in vitro model…”
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