Search Results - "Van de Walle, Tim"

Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines by Theppawong, Atiruj, Van de Walle, Tim, Grootaert, Charlotte, Bultinck, Margot, Desmet, Tom, Van Camp, John, D'hooghe, Matthias

“…Curcumin, a natural compound extracted from the rhizomes of Curcuma longa, displays pronounced anticancer properties but lacks good bioavailability and…”
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Synthesis of Non‐Symmetrical Nitrogen‐Containing Curcuminoids in the Pursuit of New Anticancer Candidates by Theppawong, Atiruj, Van de Walle, Tim, Grootaert, Charlotte, Van Hecke, Kristof, Catry, Nathalie, Desmet, Tom, Van Camp, John, D'hooghe, Matthias

“…Curcumin is known to display pronounced anticancer effects and a variety of other biological activities. However, the low bioavailability and fast metabolism…”
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Recent contributions of quinolines to antimalarial and anticancer drug discovery research by Van de Walle, Tim, Cools, Lore, Mangelinckx, Sven, D'hooghe, Matthias

“…Quinoline, a privileged scaffold in medicinal chemistry, has always been associated with a multitude of biological activities. Especially in antimalarial and…”
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Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents by Van de Walle, Tim, Boone, Maya, Van Puyvelde, Julie, Combrinck, Jill, Smith, Peter J., Chibale, Kelly, Mangelinckx, Sven, D’hooghe, Matthias

“…The parasitic disease malaria places almost half of the world’s population at risk of infection and is responsible for more than 400,000 deaths each year. The…”
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Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties by Minić, Aleksandra, Van de Walle, Tim, Van Hecke, Kristof, Combrinck, Jill, Smith, Peter J., Chibale, Kelly, D’hooghe, Matthias

“…The tropical disease malaria is responsible for more than 400,000 deaths annually, especially in Southeast Asia and Africa. Although the number of malaria…”
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Synthesis of 1,4‐Thiazepane‐Based Curcuminoids with Promising Anticancer Activity by Theppawong, Atiruj, Van de Walle, Tim, Van Hecke, Kristof, Grootaert, Charlotte, Van Camp, John, D'hooghe, Matthias

“…Curcumin, the main component of turmeric (Curcuma longa) is known to display an interesting bioactivity profile, including pronounced anticancer properties…”
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Synthesis of Novel Nitroxoline Analogs with Potent Cathepsin B Exopeptidase Inhibitory Activity by Van de Walle, Tim, Briand, Marina, Mitrović, Ana, Sosič, Izidor, Gobec, Stanislav, Kos, Janko, Persoons, Leentje, Daelemans, Dirk, De Jonghe, Steven, Ubiparip, Zorica, Desmet, Tom, Van Hecke, Kristof, Mangelinckx, Sven, D'hooghe, Matthias

“…Nitroxoline, a well‐known antimicrobial agent, has been identified in several independent studies, and on different molecular targets, as a promising candidate…”
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Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives by Van de Walle, Tim, Theppawong, Atiruj, Grootaert, Charlotte, De Jonghe, Steven, Persoons, Leentje, Daelemans, Dirk, Van Hecke, Kristof, Van Camp, John, D’hooghe, Matthias

“…A small set of structurally different monocarbonyl curcuminoids was prepared and screened for cytotoxic activity. In particular, bis-3-methoxy-4-hydroxy- and…”
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