Search Results - "Van't Land, Clinton"
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Medium branched chain fatty acids improve the profile of tricarboxylic acid cycle intermediates in mitochondrial fatty acid β‐oxidation deficient cells: A comparative study
Published in Journal of inherited metabolic disease (01-05-2022)“…Inherited errors of mitochondrial fatty acid β‐oxidation (FAO) are life threatening, even with optimum care. FAO is the major source of energy for heart and is…”
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Mitochondrial bioenergetics and cardiolipin remodeling abnormalities in mitochondrial trifunctional protein deficiency
Published in JCI insight (10-09-2024)“…Mitochondrial trifunctional protein (TFP) deficiency is an inherited metabolic disorder leading to a block in long-chain fatty acid β-oxidation. Mutations in…”
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Treatment of VLCAD-Deficient Patient Fibroblasts with Peroxisome Proliferator-Activated Receptor δ Agonist Improves Cellular Bioenergetics
Published in Cells (Basel, Switzerland) (24-08-2022)“…Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is an autosomal recessive disease that prevents the body from utilizing long-chain fatty acids for…”
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Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation
Published in Cell reports (Cambridge) (29-08-2023)“…MYC proto-oncogene dysregulation alters metabolism, translation, and other functions in ways that support tumor induction and maintenance. Although Myc+/− mice…”
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Time of day does not impact spinal serotonin levels in humans
Published in Synapse (New York, N.Y.) (01-05-2024)“…Spinal serotonin enables neuro‐motor recovery (i.e., plasticity) in patients with debilitating paralysis. While there exists time of day fluctuations in…”
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Synthetic mRNA rescues very long-chain acyl-CoA dehydrogenase deficiency in patient fibroblasts and a murine model
Published in Molecular genetics and metabolism (01-01-2023)“…Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is an inborn error of long chain fatty acid β-oxidation (FAO) with limited treatment options…”
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Body‐Wide Inactivation of the Myc‐Like Mlx Transcription Factor Network Accelerates Aging and Increases the Lifetime Cancer Incidence
Published in Advanced science (01-09-2024)“…The “Mlx” and “Myc” transcription factor networks cross‐communicate and share many common gene targets. Myc's activity depends upon its heterodimerization with…”
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Biosynthesis of the phenazine antibiotics, the saphenamycins and esmeraldins, in Streptomyces antibioticus
Published in Journal of organic chemistry (01-11-1993)Get full text
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Heptanoic and medium branched-chain fatty acids as anaplerotic treatment for medium chain acyl-CoA dehydrogenase deficiency
Published in Molecular genetics and metabolism (01-11-2023)“…Triheptanoin (triheptanoylglycerol) has shown value as anaplerotic therapy for patients with long chain fatty acid oxidation disorders but is contraindicated…”
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Messenger RNA rescues medium-chain acyl-CoA dehydrogenase deficiency in fibroblasts from patients and a murine model
Published in Human molecular genetics (04-07-2023)“…Abstract Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is the most common inherited disorder of mitochondrial fatty acid β-oxidation (FAO) in humans…”
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An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma
Published in Cell reports (Cambridge) (23-01-2024)“…Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced by the hallmark histone mutation H3K27M, which results…”
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OP007: Cardiolipin remodeling deregulation and mitochondrial bioenergetics alterations in trifunctional protein (TFP) deficiency
Published in Genetics in medicine (01-03-2022)Get full text
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Biosynthesis of Phenazine Antibiotics in Streptomyces antibioticus: Stereochemistry of Methyl Transfer from Carbon-2 of Acetate
Published in Journal of the American Chemical Society (23-06-1999)“…Stable isotope labeling experiments have shown that the biosynthesis of the monomeric phenazines, the saphenyl esters, and their dimerization products, the…”
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Biosynthetic studies of the phenazine antibiotics: Esmeraldin A and B and related metabolites
Published 01-01-1992“…A review of the occurrence and biosynthesis of phenazine derived natural products is presented. The fermentation conditions of Streptomyces antibioticus strain…”
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Dissertation