Ultrastructural immunocytochemistry of autoimmune bullous diseases

SUMMARY Advanced immunopathological assays have been developed to elucidate the pathophysiology and provide more precise nosological definitions of the immunobullous diseases. Forty‐seven patients suffering from autoimmune bullous diseases (intra‐ or subepidermal) were studied by immunoelectron micr...

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Bibliographic Details
Published in:	Australasian journal of dermatology Vol. 43; no. 2; pp. 113 - 119
Main Authors:	Karpouzis, Anthony, Vamvassakis, Emmanuel, Stavrianeas, Nicholas, Koumantaki-Mathioudaki, Elma, Karpouzi, Myrsini, Vareltzides, Anthony
Format:	Journal Article
Language:	English
Published:	Melbourne, Australia Blackwell Science Pty 01-05-2002 Blackwell
Subjects:	Adult Aged Aged, 80 and over Autoantibodies - analysis Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Autoimmune Diseases - pathology Biological and medical sciences Bullous diseases of the skin dermatitis herpetiformis Dermatology Female Humans immunoelectron microscopy immunofluorescence Male Medical sciences Microscopy, Immunoelectron Middle Aged pemphigoid pemphigus Skin - immunology Skin - ultrastructure Skin Diseases, Vesiculobullous - immunology Skin Diseases, Vesiculobullous - metabolism Skin Diseases, Vesiculobullous - pathology vesiculobullous Bullous dermatosis Human Immunopathology Skin disease Immunocytochemistry Ultrastructure Autoimmune disease
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Summary:	SUMMARY Advanced immunopathological assays have been developed to elucidate the pathophysiology and provide more precise nosological definitions of the immunobullous diseases. Forty‐seven patients suffering from autoimmune bullous diseases (intra‐ or subepidermal) were studied by immunoelectron microscopy (direct and indirect). Peroxidase staining was revealed by diaminobenzidine (determination of immune deposit location) in the majority of the cases of subepidermal bullous diseases, but in less than half of the cases of intraepidermal bullous diseases. Immunoelectron microscopy features contributed in verifying the diagnosis of rare entities such as cicatricial pemphigoid, paraneoplastic autoimmune bullous disease, linear IgA disease and epidermolysis bullosa acquisita.
Bibliography:	istex:6CA9D87248F56D1262E0F890E011076F34092CB1 ark:/67375/WNG-ZP81D45P-B ArticleID:AJD571 Anthony Karpouzis, MD. Emmanuel Vamvassakis, MD. Nicholas Stavrianeas, MD. Elma Koumantaki‐Mathioudaki, MD. Myrsini Karpouzi MD. Anthony Vareltzides, MD. Research protocol supported by the Central Council of Health of Greece. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0004-8380 1440-0960
DOI:	10.1046/j.1440-0960.2002.00571.x