Search Results - "Valya Ramakrishnan"

RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas by Bao, Zhao-Shi, Chen, Hui-Min, Yang, Ming-Yu, Zhang, Chuan-Bao, Yu, Kai, Ye, Wan-Lu, Hu, Bo-Qiang, Yan, Wei, Zhang, Wei, Akers, Johnny, Ramakrishnan, Valya, Li, Jie, Carter, Bob, Liu, Yan-Wei, Hu, Hui-Min, Wang, Zheng, Li, Ming-Yang, Yao, Kun, Qiu, Xiao-Guang, Kang, Chun-Sheng, You, Yong-Ping, Fan, Xiao-Long, Song, Wei Sonya, Li, Rui-Qiang, Su, Xiao-Dong, Chen, Clark C, Jiang, Tao

“…Studies of gene rearrangements and the consequent oncogenic fusion proteins have laid the foundation for targeted cancer therapy. To identify oncogenic fusions…”
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MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development by Akers, Johnny C, Ramakrishnan, Valya, Kim, Ryan, Skog, Johan, Nakano, Ichiro, Pingle, Sandeep, Kalinina, Juliya, Hua, Wei, Kesari, Santosh, Mao, Ying, Breakefield, Xandra O, Hochberg, Fred H, Van Meir, Erwin G, Carter, Bob S, Chen, Clark C

“…Glioblastoma cells secrete extra-cellular vesicles (EVs) containing microRNAs (miRNAs). Analysis of these EV miRNAs in the bio-fluids of afflicted patients…”
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Comparative Analysis of Technologies for Quantifying Extracellular Vesicles (EVs) in Clinical Cerebrospinal Fluids (CSF) by Akers, Johnny C, Ramakrishnan, Valya, Nolan, John P, Duggan, Erika, Fu, Chia-Chun, Hochberg, Fred H, Chen, Clark C, Carter, Bob S

“…Extracellular vesicles (EVs) have emerged as a promising biomarker platform for glioblastoma patients. However, the optimal method for quantitative assessment…”
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miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients by Akers, Johnny C., Ramakrishnan, Valya, Kim, Ryan, Phillips, Shirley, Kaimal, Vivek, Mao, Ying, Hua, Wei, Yang, Isaac, Fu, Chia-Chun, Nolan, John, Nakano, Ichiro, Yang, Yuanfan, Beaulieu, Martin, Carter, Bob S., Chen, Clark C.

“…Analysis of extracellular vesicles (EVs) derived from plasma or cerebrospinal fluid (CSF) has emerged as a promising biomarker platform for therapeutic…”
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Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression by Kozono, David, Jie Li, Masayuki Nitta, Oltea Sampetrean, David Gonda, Deepa S. Kushwaha, Dmitry Merzon, Valya Ramakrishnan, Shan Zhu, Kaya Zhu, Hiroko Matsui, Olivier Harismendy, Wei Hua, Ying Mao, Chang-Hyuk Kwon, Hideyuki Saya, Ichiro Nakano, Donald P. Pizzo, Scott R. VandenBerg, Clark C. Chen

“…The available evidence suggests that the lethality of glioblastoma is driven by small subpopulations of cells that self-renew and exhibit tumorigenicity. It…”
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Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas by Ramakrishnan, Valya, Xu, Beibei, Akers, Johnny, Nguyen, Thien, Ma, Jun, Dhawan, Sanjay, Ning, Jianfang, Mao, Ying, Hua, Wei, Kokkoli, Efrosini, Furnari, Frank, Carter, Bob S., Chen, Clark C.

“…Recurrence after radiation therapy is nearly universal for glioblastomas, the most common form of adult brain cancer. The study aims to define clinically…”
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Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid by Akers, Johnny C, Ramakrishnan, Valya, Yang, Isaac, Hua, Wei, Mao, Ying, Carter, Bob S, Chen, Clark C

“…Tumor specific genetic material can be detected in extracellular vesicles (EVs) isolated from blood, cerebrospinal fluid (CSF), and other biofluids of…”
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Differential localization of glioblastoma subtype: implications on glioblastoma pathogenesis by Steed, Tyler C, Treiber, Jeffrey M, Patel, Kunal, Ramakrishnan, Valya, Merk, Alexander, Smith, Amanda R, Carter, Bob S, Dale, Anders M, Chow, Lionel M L, Chen, Clark C

“…The subventricular zone (SVZ) has been implicated in the pathogenesis of glioblastoma. Whether molecular subtypes of glioblastoma arise from unique niches of…”
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A cerebrospinal fluid microRNA signature as biomarker for glioblastoma by Akers, Johnny C., Hua, Wei, Li, Hongying, Ramakrishnan, Valya, Yang, Zixiao, Quan, Kai, Zhu, Wei, Li, Jie, Figueroa, Javier, Hirshman, Brian R., Miller, Brittney, Piccioni, David, Ringel, Florian, Komotar, Ricardo, Messer, Karen, Galasko, Douglas R., Hochberg, Fred, Mao, Ying, Carter, Bob S., Chen, Clark C.

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DNAR-04. MICRORNA DEGRADATION ENHANCES GLIOBLASTOMA INTRA-TUMORAL HETEROGENEITY TO AUGMENT ACQUIRED TEMOZOLOMIDE RESISTANCE by Ramakrishnan, Valya, Singh, Gatikrushna, Xu, Beibei, Ackers, Johnny, Chen, Clark

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DNAR-14. MODULATING POPULATIONAL VARIANCE OF METHYL-GUANINE METHYL TRANSFERASE (MGMT) EXPRESSION THROUGH MICRORNA DEGRADATION: A NOVEL MECHANISM OF TEMOZOLOMIDE RESISTANCE by Singh, Gatikrushna, Ramakrishnan, Valya, Singh, Shilpi, Xu, Beibei, Akers, Johnny, Jiang, Tao, Wei, Hua, Ying, Mao, Chen, Clark

“…O6 methyl-guanine methyltransferase (MGMT) restores alkylated DNA to its undamaged form in a stochiometric manner to prevent the cytotoxic effects of…”
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A single-cell translocation and secretion assay (TransSeA) by Cai, Wei, Chiu, Yu-Jui, Ramakrishnan, Valya, Tsai, Yihuan, Chen, Clark, Lo, Yu-Hwa

“…Understanding biological heterogeneity at the single cell level is required for advancing insights into the complexity of human physiology and diseases. While…”
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miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression by Zhang, Wei, Zhang, Jing, Hoadley, Katherine, Kushwaha, Deepa, Ramakrishnan, Valya, Li, Shouwei, Kang, Chunsheng, You, Yongping, Jiang, Chuanlu, Song, Sonya Wei, Jiang, Tao, Chen, Clark C

“…Genome-wide microRNA (miRNA) profiling of 82 glioblastomas demonstrated that miR-181d was inversely associated with patient overall survival after correcting…”
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RDNA-01. microRNA DEGRADATION MEDIATED GENETIC HETEROGENEITY AS A NOVEL MECHANISM FOR TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA by Ramakrishnan, Valya, Akers, Johnny, Nguyen, Thien, Mao, Ying, Nitta, Masayuki, Tao, Jiang, Carter, Bob, Chen, Clark

“…Abstract Temozolomide (TMZ), the standard-of-care chemotherapy for glioblastoma, is a DNA alkylating drug. At cytotoxic doses, TMZ Induces high levels of…”
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STEM-24. RADIATION-INDUCED EXTRACELLULAR VESICLE (EV) RELEASE OF miR-603 PROMOTES IGF1-MEDIATED STEM CALL STATE IN GLIOBLASTOMAS by Ramakrishnan, Valya, Xu, Beibei, Akers, Johnny, Nguyen, Thien, Ma, Jun, Dhawan, Sanjay, Ning, Jianfang, Mao, Ying, Hua, Wei, Kokkoli, Efrosini, Furnari, Frank, Carter, Bob, Chen, Clark

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Radiation-induced Extracellular Vesicle (EV) Release of miR-603 Promotes IGF1-mediated Stem Cell State in Glioblastomas by Ramakrishnan, Valya, Xu, Beibei, Akers, Johnny, Nguyen, Thien P, Ma, Jun, Dhawan, Sanjay, Ning, Jianfang, Mao, Ying, Hua, Wei, Kokkoli, Efrosini, Furnari, Frank, Carter, Bob S, Chen, Clark C

“…INTRODUCTION Release of exosomes and extracellular vesicles (EV) by glioblastomas plays key roles in modulating the tumor microenvironment and therapeutic…”
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A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas by Kushwaha, Deepa, Ramakrishnan, Valya, Ng, Kimberly, Steed, Tyler, Nguyen, Thien, Futalan, Diahnn, Akers, Johnny C, Sarkaria, Jann, Jiang, Tao, Chowdhury, Dipanjan, Carter, Bob S, Chen, Clark C

“…MGMT expression is a critical determinant for therapeutic resistance to DNA alkylating agents. We previously demonstrated that MGMT expression is…”
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A cerebrospinal fluid microRNA signature as biomarker for glioblastoma by Akers, Johnny C, Hua, Wei, Li, Hongying, Ramakrishnan, Valya, Yang, Zixiao, Quan, Kai, Zhu, Wei, Li, Jie, Figueroa, Javier, Hirshman, Brian R, Miller, Brittney, Piccioni, David, Ringel, Florian, Komotar, Ricardo, Messer, Karen, Galasko, Douglas R, Hochberg, Fred, Mao, Ying, Carter, Bob S, Chen, Clark C

“…To develop a cerebrospinal fluid (CSF) miRNA diagnostic biomarker for glioblastoma. Glioblastoma tissue and matched CSF from the same patient (obtained prior…”
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Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway by Ramakrishnan, Valya, Pace, Betty S.

“…In response to sodium butyrate and trichostatin A treatment in erythroid cells, p38 mitogen activated protein kinase (MAPK) mediates fetal hemoglobin (HbF)…”
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Abstract LB-207: PI3Kγ inhibition suppresses glioblastoma tumorigenicity through disruption of an IL11-STAT3-MYC signaling axis between microglia and glioblastoma by Li, Jie, Kaneda, Megan M., Wang, Jiangfei, Patel, Kunal, Akers, Johnny, Ramakrishnan, Valya, Jiang, Tao, Carter, Bob S., Varner, Judith A., Chen, Clark C.

“…While mutations in isocitrate dehydrogenase (IDH) gene are associated with favorable prognosis in glioblastoma patients, the biologic basis for favorable…”
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