Search Results - "Valvezan, Alexander J."

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome by Menon, Suchithra, Dibble, Christian C., Talbott, George, Hoxhaj, Gerta, Valvezan, Alexander J., Takahashi, Hidenori, Cantley, Lewis C., Manning, Brendan D.

“…mTORC1 promotes cell growth in response to nutrients and growth factors. Insulin activates mTORC1 through the PI3K-Akt pathway, which inhibits the…”
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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals by Torrence, Margaret E, MacArthur, Michael R, Hosios, Aaron M, Valvezan, Alexander J, Asara, John M, Mitchell, James R, Manning, Brendan D

“…The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, recent…”
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GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder by Valvezan, Alexander J, Klein, Peter S

“…The canonical Wnt signaling pathway is critical for development of the mammalian central nervous system and regulates diverse processes throughout adulthood,…”
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mTORC1 activity oscillates throughout the cell cycle, promoting mitotic entry and differentially influencing autophagy induction by Joshi, Jay N., Lerner, Ariel D., Scallo, Frank, Grumet, Alexandra N., Matteson, Paul, Millonig, James H., Valvezan, Alexander J.

“…Mechanistic Target of Rapamycin Complex 1 (mTORC1) is a master metabolic regulator that is active in nearly all proliferating eukaryotic cells; however, it is…”
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The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish by Liu, Xiaolei, Jones, William D, Quesnel-Vallières, Mathieu, Devadiga, Sudhish A, Lorent, Kristin, Valvezan, Alexander J, Myers, Rebecca L, Li, Ning, Lengner, Christopher J, Barash, Yoseph, Pack, Michael, Klein, Peter S

“…Neural crest (NC) is a unique vertebrate cell type arising from the border of the neural plate and epidermis that gives rise to diverse tissues along the…”
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Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish by Valvezan, Alexander J, Huang, Jian, Lengner, Christopher J, Pack, Michael, Klein, Peter S

“…Truncating mutations in adenomatous polyposis coli (APC) are strongly linked to colorectal cancers. APC is a negative regulator of the Wnt pathway and…”
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Molecular logic of mTORC1 signalling as a metabolic rheostat by Valvezan, Alexander J., Manning, Brendan D.

“…The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) serves as a key conduit between growth signals and the metabolic processes…”
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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex by McNamara, Molly C., Hosios, Aaron M., Torrence, Margaret E., Zhao, Ting, Fraser, Cameron, Wilkinson, Meghan, Kwiatkowski, David J., Henske, Elizabeth P., Wu, Chin-Lee, Sarosiek, Kristopher A., Valvezan, Alexander J., Manning, Brendan D.

“…mTORC1 is aberrantly activated in cancer and in the genetic tumor syndrome tuberous sclerosis complex (TSC), which is caused by loss-of-function mutations in…”
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mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability by Valvezan, Alexander J., Turner, Marc, Belaid, Amine, Lam, Hilaire C., Miller, Spencer K., McNamara, Molly C., Baglini, Christian, Housden, Benjamin E., Perrimon, Norbert, Kwiatkowski, David J., Asara, John M., Henske, Elizabeth P., Manning, Brendan D.

“…The mechanistic target of rapamycin complex 1 (mTORC1) supports proliferation through parallel induction of key anabolic processes, including protein, lipid,…”
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Adenomatous Polyposis Coli (APC) Regulates Multiple Signaling Pathways by Enhancing Glycogen Synthase Kinase-3 (GSK-3) Activity by Valvezan, Alexander J., Zhang, Fang, Diehl, J. Alan, Klein, Peter S.

“…Glycogen synthase kinase-3 (GSK-3) is essential for many signaling pathways and cellular processes. As Adenomatous Polyposis Coli (APC) functions in many of…”
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Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi by Housden, Benjamin E, Valvezan, Alexander J, Kelley, Colleen, Sopko, Richelle, Hu, Yanhui, Roesel, Charles, Lin, Shuailiang, Buckner, Michael, Tao, Rong, Yilmazel, Bahar, Mohr, Stephanie E, Manning, Brendan D, Perrimon, Norbert

“…The tuberous sclerosis complex (TSC) family of tumor suppressors, TSC1 and TSC2, function together in an evolutionarily conserved protein complex that is a…”
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A review of trilaciclib, a first-in-class cyclin-dependent kinase 4/6 inhibitor, for the management of metastatic small-cell lung cancer by Patel, Twinkle I., Joshi, Jay N., Valvezan, Alexander J., Moschitto, Matthew J.

“…Cyclin-dependent kinases (CDKs) play a major role in regulating transitions within the cell cycle. Given the roles of CDK4/6 in promoting oncogenesis,…”
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Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice by O'Brien, W Timothy, Huang, Jian, Buccafusca, Roberto, Garskof, Julie, Valvezan, Alexander J, Berry, Gerard T, Klein, Peter S

“…Lithium is the first-line therapy for bipolar disorder. However, its therapeutic target remains controversial. Candidates include inositol monophosphatases,…”
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Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA) by Housden, Benjamin E., Li, Zhongchi, Kelley, Colleen, Wang, Yuanli, Hu, Yanhui, Valvezan, Alexander J., Manning, Brendan D., Perrimon, Norbert

“…Synthetic sick or synthetic lethal (SS/L) screens are a powerful way to identify candidate drug targets to specifically kill tumor cells, but this approach…”
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Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R by Filippakis, Harilaos, Alesi, Nicola, Ogorek, Barbara, Nijmeh, Julie, Khabibullin, Damir, Gutierrez, Catherine, Valvezan, Alexander J, Cunningham, James, Priolo, Carmen, Henske, Elizabeth P

“…Tuberous sclerosis complex (TSC) is a multisystem disease associated with hyperactive mTORC1. The impact of TSC1/2 deficiency on lysosome-mediated processes is…”
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IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex by Valvezan, Alexander J, McNamara, Molly C, Miller, Spencer K, Torrence, Margaret E, Asara, John M, Henske, Elizabeth P, Manning, Brendan D

“…Recent studies in distinct preclinical tumor models have established the nucleotide synthesis enzyme inosine-5'-monophosphate dehydrogenase (IMPDH) as a viable…”
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The Tumor Suppressor IAdenomatous Polyposis Coli /I Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish by Liu, Xiaolei, Jones, William D, Quesnel-Vallières, Mathieu, Devadiga, Sudhish A, Lorent, Kristin, Valvezan, Alexander J, Myers, Rebecca L, Li, Ning, Lengner, Christopher J, Barash, Yoseph, Pack, Michael, Klein, Peter S

“…Neural crest (NC) is a unique vertebrate cell type arising from the border of the neural plate and epidermis that gives rise to diverse tissues along the…”
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Glycogen synthase kinase-3 is essential for [Beta]-arrestin-2 complex formation and lithium-sensitive behaviors in mice by O'Brien, W Timothy, Huang, Jian, Buccafusca, Roberto, Garskof, Julie, Valvezan, Alexander J, Berry, Gerard T, Klein, Peter S

“…Lithium is the first-line therapy for bipolar disorder. However, its therapeutic target remains controversial. Candidates include inositol monophosphatases,…”
Get full text

Novel roles for the tumor suppressor APC through regulation of GSK-3 by Valvezan, Alexander J

“…Adenomatous Polyposis Coli (APC) is a tumor suppressor and essential negative regulator of the Wnt signaling pathway. Wnt signaling is crucial for proper…”
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