Search Results - "Valpione, Sara"

The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival by Valpione, Sara, Mundra, Piyushkumar A., Galvani, Elena, Campana, Luca G., Lorigan, Paul, De Rosa, Francesco, Gupta, Avinash, Weightman, John, Mills, Sarah, Dhomen, Nathalie, Marais, Richard

“…Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor…”
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Sex and interleukin-6 are prognostic factors for autoimmune toxicity following treatment with anti-CTLA4 blockade by Valpione, Sara, Pasquali, Sandro, Campana, Luca Giovanni, Piccin, Luisa, Mocellin, Simone, Pigozzo, Jacopo, Chiarion-Sileni, Vanna

“…Ipilimumab is a licensed immunotherapy for metastatic melanoma patients and, in the US, as adjuvant treatment for high risk melanoma radically resected. The…”
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Depression in cancer: The many biobehavioral pathways driving tumor progression by Bortolato, Beatrice, Hyphantis, Thomas N., Valpione, Sara, Perini, Giulia, Maes, Michael, Morris, Gerwyn, Kubera, Marta, Köhler, Cristiano A., Fernandes, Brisa S., Stubbs, Brendon, Pavlidis, Nicholas, Carvalho, André F.

“…•Depression is highly prevalent among individuals with cancer.•Co-morbid depression may lead to a worse prognosis among cancer patients.•Evidence instantiates…”
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Ultraviolet radiation drives mutations in a subset of mucosal melanomas by Mundra, Piyushkumar A., Dhomen, Nathalie, Rodrigues, Manuel, Mikkelsen, Lauge Hjorth, Cassoux, Nathalie, Brooks, Kelly, Valpione, Sara, Reis-Filho, Jorge S., Heegaard, Steffen, Stern, Marc-Henri, Roman-Roman, Sergio, Marais, Richard

“…Although identified as the key environmental driver of common cutaneous melanoma, the role of ultraviolet radiation (UVR)-induced DNA damage in mucosal…”
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Low dose gemcitabine-loaded lipid nanocapsules target monocytic myeloid-derived suppressor cells and potentiate cancer immunotherapy by Sasso, Maria Stella, Lollo, Giovanna, Pitorre, Marion, Solito, Samantha, Pinton, Laura, Valpione, Sara, Bastiat, Guillaume, Mandruzzato, Susanna, Bronte, Vincenzo, Marigo, Ilaria, Benoit, Jean-Pierre

“…Abstract Tumor-induced expansion of myeloid-derived suppressor cells (MDSCs) is known to impair the efficacy of cancer immunotherapy. Among pharmacological…”
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Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma by Galvani, Elena, Mundra, Piyushkumar A., Valpione, Sara, Garcia-Martinez, Pablo, Smith, Matthew, Greenall, Jonathan, Thakur, Rohit, Helmink, Beth, Andrews, Miles C., Boon, Louis, Chester, Christopher, Gremel, Gabriela, Hogan, Kate, Mandal, Amit, Zeng, Kang, Banyard, Antonia, Ashton, Garry, Cook, Martin, Lorigan, Paul, Wargo, Jennifer A., Dhomen, Nathalie, Marais, Richard

“…Although immune checkpoint inhibitors (ICIs) have achieved unprecedented results in melanoma, the biological features of the durable responses initiated by…”
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Author Correction: The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival by Valpione, Sara, Mundra, Piyushkumar A., Galvani, Elena, Campana, Luca G., Lorigan, Paul, De Rosa, Francesco, Gupta, Avinash, Weightman, John, Mills, Sarah, Dhomen, Nathalie, Marais, Richard

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Efficacy of PD-1–based immunotherapy after radiologic progression on targeted therapy in stage IV melanoma by Kreft, Sophia, Gesierich, Anja, Eigentler, Thomas, Franklin, Cindy, Valpione, Sara, Ugurel, Selma, Utikal, Jochen, Haferkamp, Sebastian, Blank, Christian, Larkin, James, Garbe, Claus, Schadendorf, Dirk, Lorigan, Paul, Schilling, Bastian

“…Targeted therapy (TT) is an effective treatment for advanced BRAFV600-mutated melanoma, but most patients eventually acquire resistance and progress. Here, we…”
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Basal cell carcinoma: 10-year experience with electrochemotherapy by Campana, Luca G, Marconato, Roberto, Valpione, Sara, Galuppo, Sara, Alaibac, Mauro, Rossi, Carlo R, Mocellin, Simone

“…Electrochemotherapy (ECT), by combining manageable cytotoxic agents with short electric pulses, represents an effective palliative skin-directed therapy. The…”
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Ablation of soft tissue tumours by long needle variable electrode-geometry electrochemotherapy: final report from a single-arm, single-centre phase-2 study by Simioni, Andrea, Valpione, Sara, Granziera, Elisa, Rossi, Carlo Riccardo, Cavallin, Francesco, Spina, Romina, Sieni, Elisabetta, Aliberti, Camillo, Stramare, Roberto, Campana, Luca Giovanni

“…Standard electrochemotherapy (ECT) is effective in many tumour types but is confined to the treatment of small superficial lesions. Variable electrode-geometry…”
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Recommendations for improving the quality of reporting clinical electrochemotherapy studies based on qualitative systematic review by Campana, Luca G., Clover, A. James P., Valpione, Sara, Quaglino, Pietro, Gehl, Julie, Kunte, Christian, Snoj, Marko, Cemazar, Maja, Rossi, Carlo R., Miklavcic, Damijan, Sersa, Gregor

“…Electrochemotherapy is becoming a well-established treatment for malignancies of skin and non-skin origin and its use is widening across Europe. The technique…”
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Development and external validation of a prognostic nomogram for metastatic uveal melanoma by Valpione, Sara, Moser, Justin C, Parrozzani, Raffaele, Bazzi, Marco, Mansfield, Aaron S, Mocellin, Simone, Pigozzo, Jacopo, Midena, Edoardo, Markovic, Svetomir N, Aliberti, Camillo, Campana, Luca G, Chiarion-Sileni, Vanna

“…Approximately 50% of patients with uveal melanoma (UM) will develop metastatic disease, usually involving the liver. The outcome of metastatic UM (mUM) is…”
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Consolidation electrochemotherapy with bleomycin in metastatic melanoma during treatment with dabrafenib by Valpione, Sara, Campana, Luca G., Pigozzo, Jacopo, Chiarion-Sileni, Vanna

“…Background. Small molecules that inhibit V600 mutated BRAF protein, such as vemurafenib and dabrafenib, are effective in treatment of metastatic melanoma. Case…”
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Angiosarcoma on Lymphedema (Stewart–Treves Syndrome): A 12-Year Follow-up after Isolated Limb Perfusion, Limb Infusion, and Electrochemotherapy by Campana, Luca G., MD, PhD, Valpione, Sara, MD, Tosi, Annalisa, MD, Rastrelli, Marco, MD, Rossi, Carlo R., MD, Aliberti, Camillo, MD

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Electrochemotherapy – Emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration by Campana, Luca G., Edhemovic, Ibrahim, Soden, Declan, Perrone, Anna M., Scarpa, Marco, Campanacci, Laura, Cemazar, Maja, Valpione, Sara, Miklavčič, Damijan, Mocellin, Simone, Sieni, Elisabetta, Sersa, Gregor

“…The treatment of tumors with electrochemotherapy (ECT) has surged over the past decade. Thanks to the transient cell membrane permeabilization induced by the…”
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Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma by Lee, Karla A., Thomas, Andrew Maltez, Bolte, Laura A., Björk, Johannes R., de Ruijter, Laura Kist, Armanini, Federica, Asnicar, Francesco, Blanco-Miguez, Aitor, Board, Ruth, Calbet-Llopart, Neus, Derosa, Lisa, Dhomen, Nathalie, Brooks, Kelly, Harland, Mark, Harries, Mark, Leeming, Emily R., Lorigan, Paul, Manghi, Paolo, Marais, Richard, Newton-Bishop, Julia, Nezi, Luigi, Pinto, Federica, Potrony, Miriam, Puig, Susana, Serra-Bellver, Patricio, Shaw, Heather M., Tamburini, Sabrina, Valpione, Sara, Vijay, Amrita, Waldron, Levi, Zitvogel, Laurence, Zolfo, Moreno, de Vries, Elisabeth G. E., Nathan, Paul, Fehrmann, Rudolf S. N., Bataille, Véronique, Hospers, Geke A. P., Spector, Tim D., Weersma, Rinse K., Segata, Nicola

“…The composition of the gut microbiome has been associated with clinical responses to immune checkpoint inhibitor (ICI) treatment, but there is limited…”
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Electrochemotherapy of superficial tumors - Current status:: Basic principles, operating procedures, shared indications, and emerging applications by Campana, Luca G, Miklavčič, Damijan, Bertino, Giulia, Marconato, Roberto, Valpione, Sara, Imarisio, Ilaria, Dieci, Maria Vittoria, Granziera, Elisa, Cemazar, Maja, Alaibac, Mauro, Sersa, Gregor

“…Treatment of superficial tumors with electrochemotherapy (ECT) has shown a steep rise over the past decade and indications range from skin cancers to locally…”
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Sequential immunotherapy regimens—expect the unexpected by Serra-Bellver, Patricio, Valpione, Sara, Lorigan, Paul

“…PD-1 inhibitors (nivolumab and pembrolizumab) are well tolerated and associated with grade 3-4 adverse events in 10-15%1,2 of patients, between 36-44% of…”
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Immune-awakening revealed by peripheral T cell dynamics after one cycle of immunotherapy by Valpione, Sara, Galvani, Elena, Tweedy, Joshua, Mundra, Piyushkumar A, Banyard, Antonia, Middlehurst, Philippa, Barry, Jeff, Mills, Sarah, Salih, Zena, Weightman, John, Gupta, Avinash, Gremel, Gabriela, Baenke, Franziska, Dhomen, Nathalie, Lorigan, Paul C, Marais, Richard

“…Our understanding of how checkpoint inhibitors (CPI) affect T cell evolution is incomplete, limiting our ability to achieve full clinical benefit from these…”
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Small datasets to develop and validate prognostic models may be a necessary evil to study rare tumours by Valpione, Sara, Mocellin, Simone, Campana, Luca Giovanni

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