Search Results - "Valore, Erika"

Identification of erythroferrone as an erythroid regulator of iron metabolism by Kautz, Léon, Jung, Grace, Valore, Erika V, Rivella, Stefano, Nemeth, Elizabeta, Ganz, Tomas

“…Tomas Ganz and colleagues identify a new regulator of iron metabolism, erythroferrone, that is produced by erythroblasts in response to erythropoietin and…”
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Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine by Li, Chunfeng, Lee, Audrey, Grigoryan, Lilit, Arunachalam, Prabhu S., Scott, Madeleine K. D., Trisal, Meera, Wimmers, Florian, Sanyal, Mrinmoy, Weidenbacher, Payton A., Feng, Yupeng, Adamska, Julia Z., Valore, Erika, Wang, Yanli, Verma, Rohit, Reis, Noah, Dunham, Diane, O’Hara, Ruth, Park, Helen, Luo, Wei, Gitlin, Alexander D., Kim, Peter, Khatri, Purvesh, Nadeau, Kari C., Pulendran, Bali

“…Despite the success of the BNT162b2 mRNA vaccine, the immunological mechanisms that underlie its efficacy are poorly understood. Here we analyzed the innate…”
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Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin by Aschemeyer, Sharraya, Qiao, Bo, Stefanova, Deborah, Valore, Erika V., Sek, Albert C., Ruwe, T. Alex, Vieth, Kyle R., Jung, Grace, Casu, Carla, Rivella, Stefano, Jormakka, Mika, Mackenzie, Bryan, Ganz, Tomas, Nemeth, Elizabeta

“…Nonclassical ferroportin disease (FD) is a form of hereditary hemochromatosis caused by mutations in the iron transporter ferroportin (Fpn), resulting in…”
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Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera by Casu, Carla, Oikonomidou, Paraskevi Rea, Chen, Huiyong, Nandi, Vijay, Ginzburg, Yelena, Prasad, Princy, Fleming, Robert E., Shah, Yatrik M., Valore, Erika V., Nemeth, Elizabeta, Ganz, Tomas, MacDonald, Brian, Rivella, Stefano

“…In β-thalassemia and polycythemia vera (PV), disordered erythropoiesis triggers severe pathophysiological manifestations. β-Thalassemia is characterized by…”
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Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin by Valore, Erika V., Ganz, Tomas

“…Hepcidin is encoded as an 84 amino acid prepropeptide containing a typical N-terminal 24 amino acid endoplasmic reticulum targeting signal sequence, and a 35…”
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A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin by Kim, Airie, Fung, Eileen, Parikh, Sona G., Valore, Erika V., Gabayan, Victoria, Nemeth, Elizabeta, Ganz, Tomas

“…Anemia is a common complication of infections and inflammatory diseases, but the few mouse models of this condition are not well characterized. We analyzed in…”
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Hepcidin-Induced Hypoferremia Is a Critical Host Defense Mechanism against the Siderophilic Bacterium Vibrio vulnificus by Arezes, João, Jung, Grace, Gabayan, Victoria, Valore, Erika, Ruchala, Piotr, Gulig, Paul A., Ganz, Tomas, Nemeth, Elizabeta, Bulut, Yonca

“…Hereditary hemochromatosis, an iron overload disease caused by a deficiency in the iron-regulatory hormone hepcidin, is associated with lethal infections by…”
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Calcium is an essential cofactor for metal efflux by the ferroportin transporter family by Deshpande, Chandrika N., Ruwe, T. Alex, Shawki, Ali, Xin, Vicky, Vieth, Kyle R., Valore, Erika V., Qiao, Bo, Ganz, Tomas, Nemeth, Elizabeta, Mackenzie, Bryan, Jormakka, Mika

“…Ferroportin (Fpn)—the only known cellular iron exporter—transports dietary and recycled iron into the blood plasma, and transfers iron across the placenta…”
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Author Correction: Identification of erythroferrone as an erythroid regulator of iron metabolism by Kautz, Léon, Jung, Grace, Valore, Erika V., Rivella, Stefano, Nemeth, Elizabeta, Ganz, Tomas

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4 by Lin, Lan, Valore, Erika V., Nemeth, Elizabeta, Goodnough, Julia B., Gabayan, Victoria, Ganz, Tomas

“…The peptide hormone hepcidin is the principal regulator of systemic iron homeostasis. We examined the pathway by which iron stimulates the production of…”
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Mice lacking liver-specific β-catenin develop steatohepatitis and fibrosis after iron overload by Preziosi, Morgan E, Singh, Sucha, Valore, Erika V, Jung, Chun-Ling, Popovic, Branimir, Poddar, Minakshi, Nagarajan, Shanmugam, Ganz, Tomas, Monga, Satdarshan P

“…Graphical abstract…”
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Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein by Nemeth, Elizabeta, Valore, Erika V., Territo, Mary, Schiller, Gary, Lichtenstein, Alan, Ganz, Tomas

“…Hepcidin is a liver-made peptide proposed to be a central regulator of intestinal iron absorption and iron recycling by macrophages. In animal models, hepcidin…”
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Effects of dietary iron intake and chronic kidney disease on fibroblast growth factor 23 metabolism in wild-type and hepcidin knockout mice by Hanudel, Mark R, Chua, Kristine, Rappaport, Maxime, Gabayan, Victoria, Valore, Erika, Goltzman, David, Ganz, Tomas, Nemeth, Elizabeta, Salusky, Isidro B

“…In the setting of normal kidney function, iron deficiency is associated with increased FGF23 production and cleavage, altering circulating FGF23 levels. Our…”
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Reversible Deficiency of Antimicrobial Polypeptides in Bacterial Vaginosis by Valore, Erika V, Wiley, Dorothy J, Ganz, Tomas

“…Bacterial vaginosis is a common condition associated with increased risk of sexually transmitted diseases, including human immunodeficiency virus infections…”
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Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2 by Adamska, Julia Z., Verma, Rohit, Gupta, Shakti, Hagan, Thomas, Wimmers, Florian, Floyd, Katharine, Li, Qin, Valore, Erika V., Wang, Yanli, Trisal, Meera, Vilches-Moure, José G., Subramaniam, Shankar, Walkley, Carl R., Suthar, Mehul S., Li, Jin Billy, Pulendran, Bali

“…Under normal homeostatic conditions, self-double-stranded RNA (self-dsRNA) is modified by adenosine deaminase acting on RNA 1 (ADAR1) to prevent the induction…”
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Detection of antimicrobial (poly)peptides with acid urea polyacrylamide gel electrophoresis followed by Western immunoblot by Porter, Edith, Valore, Erika V, Anouseyan, Rabin, Salzman, Nita H

“…Antimicrobial (poly)peptides (AMPs) are ancient key effector molecules of innate host defense and have been identified in mammals, insects, plants, and even…”
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Antimicrobial factors in the cervical mucus plug by Hein, Merete, Valore, Erika V., Helmig, Rikke Bek, Uldbjerg, Niels, Ganz, Tomas

“…Objective: The cervical mucus plug is positioned between the microbe-rich vagina and the normally sterile uterine cavity, which suggests a host defense…”
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Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor by Sørensen, Ole E, Thapa, Dharma R, Roupé, K Markus, Valore, Erika V, Sjöbring, Ulf, Roberts, Alice A, Schmidtchen, Artur, Ganz, Tomas

“…We found that sterile wounding of human skin induced epidermal expression of the antimicrobial (poly)peptides human beta-defensin-3, neutrophil…”
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Human β-Defensin-2 Production in Keratinocytes is Regulated by Interleukin-1, Bacteria, and the State of Differentiation by Liu, Alice Y., Destoumieux, Delphine, Wong, Annie V., Park, Christina H., Valore, Erika V., Liu, Lide, Ganz, Tomas

“…Intact human epidermis resists invasion by pathogenic microbes but the biochemical basis of its resistance is not well understood. Recently, an antimicrobial…”
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Differential Processing of α- and β-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7) by Wilson, Carole L., Schmidt, Amy P., Pirilä, Emma, Valore, Erika V., Ferri, Nicola, Sorsa, Timo, Ganz, Tomas, Parks, William C.

“…Proteolytic processing of defensins is a critical mode of posttranslational regulation of peptide activity. Because mouse α-defensin precursors are cleaved and…”
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