Search Results - "Valmir Fadel"
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Biophysical and pharmacological characterization of a full-length synthetic analog of the antitumor polypeptide crotamine
Published in Journal of molecular medicine (Berlin, Germany) (01-11-2020)“…Crotamine is a polypeptide isolated from the venom of a South American rattlesnake. Among the properties and biological activities of crotamine, the most…”
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2
Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2- trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis
Published in Journal of structural biology (01-09-2007)“…The resumption of tuberculosis led to an increased need to understand the molecular mechanisms of drug action and drug resistance, which should provide…”
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3
Automated NMR structure determination and disulfide bond identification of the myotoxin crotamine from Crotalus durissus terrificus
Published in Toxicon (Oxford) (01-12-2005)“…Crotamine is one of four major components of the venom of the South American rattlesnake Crotalus durissus terrificus. Similar to its counterparts in the…”
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4
Thermal intermittent drying of apples and its effects on energy consumption
Published in Drying technology (26-10-2018)“…This study investigated thermal intermittence in apple drying, conducted in two stages, and its effect on energy consumption, drying kinetics, color and…”
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5
Synthesis and Characterization of Peptide–Chitosan Conjugates (PepChis) with Lipid Bilayer Affinity and Antibacterial Activity
Published in Biomacromolecules (08-07-2019)“…Antimicrobial peptides appear among innovative biopolymers with potential therapeutic interest. Nevertheless, issues concerning efficiency, production costs,…”
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6
Protonectin peptides target lipids, act at the interface and selectively kill metastatic breast cancer cells while preserving morphological integrity
Published in Journal of colloid and interface science (01-11-2021)“…[Display omitted] Despite the need for innovative compounds as antimicrobial and anticancer agents, natural sources of peptides remain underexplored…”
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7
Membrane targeting peptides toward antileishmanial activity: Design, structural determination and mechanism of interaction
Published in Biochimica et biophysica acta. General subjects (01-11-2017)“…Leishmaniasis threatens poor areas population worldwide, requiring new drugs less prone to resistance development. Antimicrobial peptides with antileishmanial…”
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Crystal structure of hemoglobin from the maned wolf (Chrysocyon brachyurus) using synchrotron radiation
Published in Protein and peptide letters (01-12-2003)“…Crystal structure of hemoglobin isolated from the Brazilian maned wolf (Chrysocyon brachyurus) was determined using standard molecular replacement technique…”
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MD simulations and multivariate studies for modeling the antileishmanial activity of peptides
Published in Chemical biology & drug design (01-10-2017)“…Leishmaniasis, a protozoan‐caused disease, requires alternative treatments with minimized side‐effects and less prone to resistance development. Antimicrobial…”
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10
Crystallographic studies of fish hemoglobins
Published in Eclética química (01-01-2000)“…The present work reports our succesfull experience concerning crystallization of four fish hemoglobins from three Brazilian species of Teleosts: Liposarcus…”
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11
New catalytic mechanism for human purine nucleoside phosphorylase
Published in Biochemical and biophysical research communications (18-02-2005)“…Human purine nucleoside phosphorylase has been submitted to intensive structure-based design of inhibitors, most of them using low-resolution structures of…”
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12
Crystal structure of human PNP complexed with hypoxanthine and sulfate ion
Published in Biochemical and biophysical research communications (14-01-2005)“…Purine nucleoside phosphorylase (PNP) is a ubiquitous enzyme, which plays a key role in the purine salvage pathway, and PNP deficiency in humans leads to an…”
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13
Molecular Model for the Binary Complex of Uropepsin and Pepstatin
Published in Biochemical and biophysical research communications (14-09-2001)“…The three-dimensional structure of human uropepsin complexed with pepstatin has been modelled using human pepsin as a template. Uropepsin is an aspartic…”
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14
Structure of human uropepsin at 2.45 Å resolution
Published in Acta crystallographica. Section D, Biological crystallography. (01-11-2001)“…The molecular structure of human uropepsin, an aspartic proteinase from the urine produced in the form of pepsinogen A in the gastric mucosa, has been…”
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15
Crystallographic studies of fish hemoglobins
Published in Eclética química (04-12-2000)“…The present work reports our succesfull experience concerning crystallization of four fish hemoglobins from three Brazilian species of Teleosts: Liposarcus…”
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16
Crystallographic studies of fishhemoglobins
Published in Eclética química (2000)Get full text
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