Search Results - "Valm, Alex"

The Structure of Dental Plaque Microbial Communities in the Transition from Health to Dental Caries and Periodontal Disease by Valm, Alex M.

“…The human oral cavity harbors diverse communities of microbes that live as biofilms: highly ordered, surface-associated assemblages of microbes embedded in an…”
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Interacting organelles by Cohen, Sarah, Valm, Alex M, Lippincott-Schwartz, Jennifer

“…Eukaryotic cells are organized into membrane-bound organelles. These organelles communicate with one another through vesicular trafficking pathways and…”
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Multiplexed Spectral Imaging of 120 Different Fluorescent Labels by Valm, Alex M, Oldenbourg, Rudolf, Borisy, Gary G

“…The number of fluorescent labels that can unambiguously be distinguished in a single image when acquired through band pass filters is severely limited by the…”
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Applying systems-level spectral imaging and analysis to reveal the organelle interactome by Valm, Alex M., Cohen, Sarah, Legant, Wesley R., Melunis, Justin, Hershberg, Uri, Wait, Eric, Cohen, Andrew R., Davidson, Michael W., Betzig, Eric, Lippincott-Schwartz, Jennifer

“…Using confocal and lattice light sheet microscopy, the authors perform systems-level analysis of the organelle interactome in live cells, allowing them to…”
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Spatial scale in analysis of the dental plaque microbiome by Borisy, Gary G., Valm, Alex M., Darveau, Richard, Curtis, Mike

“…Ecologists have long recognized the importance of spatial scale in understanding structure‐function relationships among communities of organisms within their…”
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Unmixing biological fluorescence image data with sparse and low-rank Poisson regression by Wang, Ruogu, Lemus, Alex A, Henneberry, Colin M, Ying, Yiming, Feng, Yunlong, Valm, Alex M

“…Abstract Motivation Multispectral biological fluorescence microscopy has enabled the identification of multiple targets in complex samples. The accuracy in the…”
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Interaction between the microbiome and TP53 in human lung cancer by Greathouse, K Leigh, White, James R, Vargas, Ashely J, Bliskovsky, Valery V, Beck, Jessica A, von Muhlinen, Natalia, Polley, Eric C, Bowman, Elise D, Khan, Mohammed A, Robles, Ana I, Cooks, Tomer, Ryan, Bríd M, Padgett, Noah, Dzutsev, Amiran H, Trinchieri, Giorgio, Pineda, Marbin A, Bilke, Sven, Meltzer, Paul S, Hokenstad, Alexis N, Stickrod, Tricia M, Walther-Antonio, Marina R, Earl, Joshua P, Mell, Joshua C, Krol, Jaroslaw E, Balashov, Sergey V, Bhat, Archana S, Ehrlich, Garth D, Valm, Alex, Deming, Clayton, Conlan, Sean, Oh, Julia, Segre, Julie A, Harris, Curtis C

“…Lung cancer is the leading cancer diagnosis worldwide and the number one cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung…”
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Systems-level analysis of microbial community organization through combinatorial labeling and spectral imaging by Valm, Alex M, Welch, Jessica L. Mark, Rieken, Christopher W, Hasegawa, Yuko, Sogin, Mitchell L, Oldenbourg, Rudolf, Dewhirst, Floyd E, Borisy, Gary G

“…Microbes in nature frequently function as members of complex multitaxon communities, but the structural organization of these communities at the micrometer…”
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A feedback loop between heterochromatin and the nucleopore complex controls germ-cell-to-oocyte transition during Drosophila oogenesis by Sarkar, Kahini, Kotb, Noor M., Lemus, Alex, Martin, Elliot T., McCarthy, Alicia, Camacho, Justin, Iqbal, Ayman, Valm, Alex M., Sammons, Morgan A., Rangan, Prashanth

“…Germ cells differentiate into oocytes that launch the next generation upon fertilization. How the highly specialized oocyte acquires this distinct cell fate is…”
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Interbacterial Adhesion Networks within Early Oral Biofilms of Single Human Hosts by Palmer, Jr, Robert J, Shah, Nehal, Valm, Alex, Paster, Bruce, Dewhirst, Floyd, Inui, Taichi, Cisar, John O

“…Specific interbacterial adhesion, termed coaggregation, is well established for three early colonizers of the plaque biofilm: streptococci, actinomyces, and…”
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Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers by Stefan, Christopher J, Trimble, William S, Grinstein, Sergio, Drin, Guillaume, Reinisch, Karin, De Camilli, Pietro, Cohen, Sarah, Valm, Alex M, Lippincott-Schwartz, Jennifer, Levine, Tim P, Iaea, David B, Maxfield, Frederick R, Futter, Clare E, Eden, Emily R, Judith, Delphine, van Vliet, Alexander R, Agostinis, Patrizia, Tooze, Sharon A, Sugiura, Ayumu, McBride, Heidi M

“…Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the…”
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In Vitro Dental Plaque Culture Model for Biofilm Structural Analyses by Lemus, Alex A, Valm, Alex M

“…Extensive research has focused on the compositional changes in dental plaque microbiome communities during the transition from health to disease, known as…”
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Multispectral Live-Cell Imaging by Cohen, Sarah, Valm, Alex M, Lippincott-Schwartz, Jennifer

“…Fluorescent proteins and vital dyes are invaluable tools for studying dynamic processes within living cells. However, the ability to distinguish more than a…”
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CLASI-FISH: Principles of combinatorial labeling and spectral imaging by Valm, Alex M., Mark Welch, Jessica L., Borisy, Gary G.

“…Although the number of phylotypes present in a microbial community may number in the hundreds or more, until recently, fluorescence in situ hybridization has…”
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Interactions between Candida albicans and Enterococcus faecalis in an Organotypic Oral Epithelial Model by Krishnamoorthy, Akshaya Lakshmi, Lemus, Alex A, Solomon, Adline Princy, Valm, Alex M, Neelakantan, Prasanna

“…as an opportunistic pathogen exploits the host immune system and causes a variety of life-threatening infections. The polymorphic nature of this fungus gives…”
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Author Correction: Interaction between the microbiome and TP53 in human lung cancer by Greathouse, K Leigh, White, James R, Vargas, Ashely J, Bliskovsky, Valery V, Beck, Jessica A, von Muhlinen, Natalia, Polley, Eric C, Bowman, Elise D, Khan, Mohammed A, Robles, Ana I, Cooks, Tomer, Ryan, Bríd M, Padgett, Noah, Dzutsev, Amiran H, Trinchieri, Giorgio, Pineda, Marbin A, Bilke, Sven, Meltzer, Paul S, Hokenstad, Alexis N, Stickrod, Tricia M, Walther-Antonio, Marina R, Earl, Joshua P, Mell, Joshua C, Krol, Jaroslaw E, Balashov, Sergey V, Bhat, Archana S, Ehrlich, Garth D, Valm, Alex, Deming, Clayton, Conlan, Sean, Oh, Julia, Segre, Julie A, Harris, Curtis C

“…Following publication of the original paper [1], the authors submitted a new Additional file 5 to replace the one containing formatting issues. The updated…”
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Recent progress in analyzing the spatial structure of the human microbiome: Distinguishing biogeography and architecture in the oral and gut communities by Adade, Emmanuel E., Al Lakhen, Khalid, Lemus, Alex A., Valm, Alex M.

“…Fueled by technological advances in methods for sample collection and preservation in sequencing studies and in advances in computational analyses of…”
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Systems Imaging to Reveal the Eukaryotic Organelle Interactome and Oral Microbiome Structure and Assembly by Valm, Alex

“…To fully understand the function of any biological system, it is often necessary to know how the different components of the system are arranged in space…”
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Imaging Marine Bacteria with Unique 16S rRNA V6 Sequences by Fluorescence in situ Hybridization and Spectral Analysis by Hasegawa, Yuko, Welch, Jessica L. Mark, Valm, Alex M., Rieken, Christopher W., Sogin, Mitchell L., Borisy, Gary G.

“…Fluorescence in situ hybridization (FISH) combined with spectral analysis was performed to image specific bacteria from seawater using probes targeting the V6…”
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Abstract 4925: Microbiome-TP53 gene interaction in human lung cancer by Greathouse, Leigh, White, James, Bliskovsky, Valery, Vargas, Ashley, Polley, Eric, Bowman, Elise, Khan, Mohammed, Robles, Ana, Ryan, Brid, Dzutsev, Amiran, Trinchieri, Giorgio, Pineda, Marbin, Bilke, Sven, Meltzer, Paul, Walther-Antonio, Marina, Ehrlich, Garth, Mell, Joshua, Earl, Joshua, Balashov, Sergey, Bhat, Archana, Valm, Alex, Deming, Clayton, Conlan, Sean, Oh, Julia, Segre, Julie, Harris, Curtis

“…Abstract Lung cancer is the leading cancer diagnosis worldwide and the number one cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor…”
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