Search Results - "Vallis, Katherine A."

Transition metal compounds as cancer radiosensitizers by Gill, Martin R, Vallis, Katherine A

“…The concomitant administration of ionising radiation (IR) in the form of external beam radiotherapy or targeted radionuclide therapy (TRT) alongside…”
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Targeted radionuclide therapy in combined-modality regimens by Gill, Martin R, Falzone, Nadia, Du, Yong, Vallis, Katherine A

“…Targeted radionuclide therapy (TRT) is a branch of cancer medicine concerned with the use of radioisotopes, radiolabelled molecules, nanoparticles, or…”
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Subcellular Targeting of Theranostic Radionuclides by Bavelaar, Bas M, Lee, Boon Q, Gill, Martin R, Falzone, Nadia, Vallis, Katherine A

“…The last decade has seen rapid growth in the use of theranostic radionuclides for the treatment and imaging of a wide range of cancers. Radionuclide therapy…”
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Megavoltage Radiosensitization of Gold Nanoparticles on a Glioblastoma Cancer Cell Line Using a Clinical Platform by Kazmi, Farasat, Vallis, Katherine A, Vellayappan, Balamurugan A, Bandla, Aishwarya, Yukun, Duan, Carlisle, Robert

“…Gold nanoparticles (GNPs) have demonstrated significant dose enhancement with kilovoltage (kV) X-rays; however, recent studies have shown inconsistent findings…”
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Targeted Radionuclide Therapy: New Advances for Improvement of Patient Management and Response by Malcolm, Javian, Falzone, Nadia, Lee, Boon Q, Vallis, Katherine A

“…Compared to external beam radiotherapy, targeted radionuclide therapy (TRT) allows for systemic radiation treatment of metastatic lesions. Published work on…”
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Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer Cells by Jackson, Mark R, Bavelaar, Bas M, Waghorn, Philip A, Gill, Martin R, El-Sagheer, Afaf H, Brown, Tom, Tarsounas, Madalena, Vallis, Katherine A

“…Telomerase is expressed in the majority (>85%) of tumors, but has restricted expression in normal tissues. Long-term telomerase inhibition in malignant cells…”
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A three-in-one-bullet for oesophageal cancer: replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(ii) metallo-intercalator by Gill, Martin R, Jarman, Paul J, Halder, Swagata, Walker, Michael G, Saeed, Hiwa K, Thomas, Jim A, Smythe, Carl, Ramadan, Kristijan, Vallis, Katherine A

“…Substitutionally inert ruthenium(ii) polypyridyl complexes have been developed as DNA intercalating agents yet cellular DNA damage responses to this binding…”
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Ultrasound-mediated cavitation enhances the delivery of an EGFR-targeting liposomal formulation designed for chemo-radionuclide therapy by Thomas, Eloise, Menon, Jyothi U, Owen, Joshua, Skaripa-Koukelli, Irini, Wallington, Sheena, Gray, Michael, Mannaris, Christophoros, Kersemans, Veerle, Allen, Danny, Kinchesh, Paul, Smart, Sean, Carlisle, Robert, Vallis, Katherine A

“…Nanomedicines allow active targeting of cancer for diagnostic and therapeutic applications through incorporation of multiple functional components. Frequently,…”
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Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells by Tietz, Ole, Cortezon-Tamarit, Fernando, Chalk, Rod, Able, Sarah, Vallis, Katherine A.

“…The intracellular environment hosts a large number of cancer- and other disease-relevant human proteins. Targeting these with internalized antibodies would…”
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Proteomic analyses reveal high expression of decorin and endoplasmin (HSP90B1) are associated with breast cancer metastasis and decreased survival by Cawthorn, Thomas R, Moreno, Juan C, Dharsee, Moyez, Tran-Thanh, Danh, Ackloo, Suzanne, Zhu, Pei Hong, Sardana, Girish, Chen, Jian, Kupchak, Peter, Jacks, Lindsay M, Miller, Naomi A, Youngson, Bruce J, Iakovlev, Vladimir, Guidos, Cynthia J, Vallis, Katherine A, Evans, Kenneth R, McCready, David, Leong, Wey L, Done, Susan J

“…Breast cancer is the most common malignancy among women worldwide in terms of incidence and mortality. About 10% of North American women will be diagnosed with…”
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Cone Beam Computed Tomography Guidance for Setup of Patients Receiving Accelerated Partial Breast Irradiation by White, Elizabeth A., B.Sc, Cho, John, M.D., Ph.D, Vallis, Katherine A., M.D, Sharpe, Michael B., Ph.D, Lee, Grace, B.Sc, Blackburn, Helen, B.Sc, Nageeti, Tahani, M.D, McGibney, Carol, M.D, Jaffray, David A., Ph.D

“…Purpose: To evaluate the role of cone-beam CT (CBCT) guidance for setup error reduction and soft tissue visualization in accelerated partial breast irradiation…”
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Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity by Then, Chee Kin, Paillas, Salome, Moomin, Aliu, Misheva, Mariya D, Moir, Rachel A, Hay, Susan M, Bremner, David, Roberts Nee Nellany, Kristine S, Smith, Ellen E, Heidari, Zeynab, Sescu, Daniel, Wang, Xuedan, Suárez-Bonnet, Alejandro, Hay, Nadine, Murdoch, Sarah L, Saito, Ryoichi, Collie-Duguid, Elaina S R, Richardson, Shirley, Priestnall, Simon L, Wilson, Joan M, Gurumurthy, Mahalakshmi, Royle, Justine S, Samuel, Leslie M, Ramsay, George, Vallis, Katherine A, Foster, Kevin R, McCullagh, James S O, Kiltie, Anne E

“…Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre…”
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Radioimmunotherapy for Brain Metastases: The Potential for Inflammation as a Target of Choice by Corroyer-Dulmont, Aurélien, Jaudet, Cyril, Frelin, Anne-Marie, Fantin, Jade, Weyts, Kathleen, Vallis, Katherine A, Falzone, Nadia, Sibson, Nicola R, Chérel, Michel, Kraeber-Bodéré, Françoise, Batalla, Alain, Bardet, Stéphane, Bernaudin, Myriam, Valable, Samuel

“…Brain metastases (BM) are frequently detected during the follow-up of patients with malignant tumors, particularly in those with advanced disease. Despite a…”
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3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation by Skaripa-Koukelli, Irini, Hauton, David, Walsby-Tickle, John, Thomas, Eloïse, Owen, Joshua, Lakshminarayanan, Abirami, Able, Sarah, McCullagh, James, Carlisle, Robert C, Vallis, Katherine A

“…Triple negative breast cancer (TNBC) poses a serious clinical challenge as it is an aggressive form of the disease that lacks estrogen receptor, progesterone…”
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Impact of cyclic changes in pharmacokinetics and absorbed dose in pediatric neuroblastoma patients receiving [177Lu]Lu-DOTATATE by Malcolm, Javian C., Falzone, Nadia, Gains, Jennifer E., Aldridge, Matthew D., Mirando, David, Lee, Boon Q., Gaze, Mark N., Vallis, Katherine A.

“…Purpose Recent reports personalizing the administered activity (AA) of each cycle of peptide receptor radionuclide therapy based on the predicted absorbed dose…”
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Orally administered oxygen nanobubbles enhance tumor response to sonodynamic therapy by Owen, Joshua, Logan, Keiran, Nesbitt, Heather, Able, Sarah, Vasilyeva, Alexandra, Bluemke, Emma, Kersemans, Veerle, Smart, Sean, Vallis, Katherine A., McHale, Anthony P., Callan, John F., Stride, Eleanor

“…Suspensions of oxygen‐filled bubbles are under active investigation as potential means of relieving tissue hypoxia. Intravenous administration of large…”
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An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse by Kersemans, Veerle, Beech, John S, Gilchrist, Stuart, Kinchesh, Paul, Allen, Philip D, Thompson, James, Gomes, Ana L, D'Costa, Zenobia, Bird, Luke, Tullis, Iain D C, Newman, Robert G, Corroyer-Dulmont, Aurelien, Falzone, Nadia, Azad, Abul, Vallis, Katherine A, Sansom, Owen J, Muschel, Ruth J, Vojnovic, Borivoj, Hill, Mark A, Fokas, Emmanouil, Smart, Sean C

“…Preclinical CT-guided radiotherapy platforms are increasingly used but the CT images are characterized by poor soft tissue contrast. The aim of this study was…”
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Stereotactic Inverse Dose Planning After Yttrium-90 Selective Internal Radiation Therapy in Hepatocellular Cancer by Abbott, Elliot, Young, Robert Steve, Hale, Caroline, Mitchell, Kimberly, Falzone, Nadia, Vallis, Katherine A., Kennedy, Andrew

“…Selective internal radiation therapy (SIRT) is administered to treat tumors of the liver and is generally well tolerated. Although widely adopted for its…”
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Relationship Between Chromatin Structure and Sensitivity to Molecularly Targeted Auger Electron Radiation Therapy by Terry, Samantha Y.A., Ph.D, Vallis, Katherine A., Ph.D

“…Purpose The open structure of euchromatin renders it susceptible to DNA damage by ionizing radiation (IR) compared with compact heterochromatin. The effect of…”
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EGF-coated gold nanoparticles provide an efficient nano-scale delivery system for the molecular radiotherapy of EGFR-positive cancer by Song, Lei, Falzone, Nadia, Vallis, Katherine A.

“…Purpose Radiolabeled antibodies and peptides hold promise for molecular radiotherapy but are often limited by a low payload resulting in inadequate delivery of…”
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