Search Results - "Vallejo, Adrián"

Accurate prediction of kinase-substrate networks using knowledge graphs by Nováček, Vít, McGauran, Gavin, Matallanas, David, Vallejo Blanco, Adrián, Conca, Piero, Muñoz, Emir, Costabello, Luca, Kanakaraj, Kamalesh, Nawaz, Zeeshan, Walsh, Brian, Mohamed, Sameh K, Vandenbussche, Pierre-Yves, Ryan, Colm J, Kolch, Walter, Fey, Dirk

“…Phosphorylation of specific substrates by protein kinases is a key control mechanism for vital cell-fate decisions and other cellular processes. However,…”
Get full text

FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted by Vallejo, Adrián, Erice, Oihane, Entrialgo-Cadierno, Rodrigo, Feliu, Iker, Guruceaga, Elizabeth, Perugorria, Maria J., Olaizola, Paula, Muggli, Alexandra, Macaya, Irati, O’Dell, Michael, Ruiz-Fernandez de Cordoba, Borja, Ortiz-Espinosa, Sergio, Hezel, Aram F., Arozarena, Imanol, Lecanda, Fernando, Avila, Matias A., Fernandez-Barrena, Maite G., Evert, Matthias, Ponz-Sarvise, Mariano, Calvisi, Diego F., Banales, Jesus M., Vicent, Silve

“…Cholangiocarcinoma (CCA) is a neoplasia of the biliary tract driven by genetic, epigenetic and transcriptional mechanisms. Herein, we investigated the role of…”
Get full text

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer by Vallejo, Adrian, Perurena, Naiara, Guruceaga, Elisabet, Mazur, Pawel K., Martinez-Canarias, Susana, Zandueta, Carolina, Valencia, Karmele, Arricibita, Andrea, Gwinn, Dana, Sayles, Leanne C., Chuang, Chen-Hua, Guembe, Laura, Bailey, Peter, Chang, David K., Biankin, Andrew, Ponz-Sarvise, Mariano, Andersen, Jesper B., Khatri, Purvesh, Bozec, Aline, Sweet-Cordero, E. Alejandro, Sage, Julien, Lecanda, Fernando, Vicent, Silve

“…KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper…”
Get full text

Chronic kidney disease promotes cerebral microhemorrhage formation by Fang, Chuo, Lau, Wei Ling, Sun, Jiahong, Chang, Rudy, Vallejo, Adrian, Lee, Donghy, Liu, Jihua, Liu, Han, Hung, Yu-Han, Zhao, Yitong, Paganini-Hill, Annlia, Sumbria, Rachita K, Cribbs, David H, Fisher, Mark

“…Chronic kidney disease (CKD) is increasingly recognized as a stroke risk factor, but its exact relationship with cerebrovascular disease is not…”
Get full text

The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer by Entrialgo-Cadierno, Rodrigo, Cueto-Ureña, Cristina, Welch, Connor, Feliu, Iker, Macaya, Irati, Vera, Laura, Morales, Xabier, Michelina, Sandra Vietti, Scaparone, Pietro, Lopez, Ines, Darbo, Elodie, Erice, Oihane, Vallejo, Adrian, Moreno, Haritz, Goñi-Salaverri, Ainhoa, Lara-Astiaso, David, Halberg, Nils, Cortes-Dominguez, Ivan, Guruceaga, Elizabeth, Ambrogio, Chiara, Lecanda, Fernando, Vicent, Silve

“…The discovery of functionally relevant KRAS effectors in lung and pancreatic ductal adenocarcinoma (LUAD and PDAC) may yield novel molecular targets or…”
Get full text

Inhibitor of differentiation-1 (Id1) sustains mutant KRAS-driven progression, maintenance, and metastasis of lung adenocarcinoma via regulation of a FOSL1 network by Román, Marta, López, Inés, Guruceaga, Elizabeth, Baraibar, Iosune, Ecay, Margarita, Collantes, María, Nadal, Ernest, Vallejo, Adrián, Cadenas, Silvia, Echávarri-de Miguel, Marta, Jang, Jae Hwi, San Martín-Uriz, Patxi, Castro-Labrador, Laura, Vilas-Zornoza, Amaia, Lara-Astiaso, David, Ponz-Sarvise, Mariano, Rolfo, Christian, Santos, Edgardo S, Raez, Luis E, Taverna, Simona, Behrens, Carmen, Weder, Walter, Wistuba, Ignacio I, Vicent, Silvestre, Gil-Bazo, Ignacio

“…Due to the refractory nature of mutant KRAS lung adenocarcinoma (LUAD) to current therapies, identification of new molecular targets is essential. Genes with a…”
Get full text

Correction: The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer by Entrialgo-Cadierno, Rodrigo, Cueto-Ureña, Cristina, Welch, Connor, Feliu, Iker, Macaya, Irati, Vera, Laura, Morales, Xabier, Michelina, Sandra Vietti, Scaparone, Pietro, Lopez, Ines, Darbo, Elodie, Erice, Oihane, Vallejo, Adrian, Moreno, Haritz, Goñi-Salaverri, Ainhoa, Lara-Astiaso, David, Halberg, Nils, Cortes-Dominguez, Ivan, Guruceaga, Elizabeth, Ambrogio, Chiara, Lecanda, Fernando, Vicent, Silve

Get full text

Genetic Mouse Models as In Vivo Tools for Cholangiocarcinoma Research by Erice, Oihane, Vallejo, Adrian, Ponz-Sarvise, Mariano, Saborowski, Michael, Vogel, Arndt, Calvisi, Diego F, Saborowski, Anna, Vicent, Silvestre

“…Cholangiocarcinoma (CCA) is a genetically and histologically complex disease with a highly dismal prognosis. A deeper understanding of the underlying cellular…”
Get full text

All for one and FOSL1 for all: FOSL1 at the crossroads of lung and pancreatic cancer driven by mutant KRAS by Vallejo, Adrian, Valencia, Karmele, Vicent, Silvestre

“…KRAS proto-oncogene, GTPase (KRAS) remains refractory to current therapies. We devised an integrative cross-tumor approach to expose common core elements…”
Get full text

Analysis of Common Exercise Modalities in Improving Athletic Performance in Older Adults: A Narrative Review by Nguyen, Chantal, Kaufman, Matthew, Vallejo, Adrian, DeParis, Sarah, Friedlander, Anne, Frehlich, Levi, Fredericson, Michael

“…Exercise leads to robust cardiovascular, musculoskeletal, and psychological benefits that improve quality of life and longevity for older adults, but…”
Get full text

Abstract TP127: Hypertension Provokes Development Of Cerebral Microhemorrhages In A Mouse Model by Fang, Chuo, Lau, Wei Ling, Vallejo, Adrian, Liu, Jihua, Liu, Han, Paganini-Hill, Annlia, Cribbs, David H, Fisher, Mark

“…IntroductionCerebral microhemorrhages (CMH) are the pathological substrate for cerebral microbleeds, represent focal hemosiderin deposits on MRI, and are…”
Get full text

Abstract 87: Chronic Kidney Disease Induces Cerebral Microhemorrhages In Aged Mice by Fang, Chuo, Lau, Wei Ling, Sun, Jessica, Vallejo, Adrian, Liu, Jihua, Liu, Han, Paganini-Hill, Annlia, Sumbria, Rachita K, Cribbs, David H, Fisher, Mark

“…IntroductionChronic kidney disease (CKD) is increasingly recognized as a risk factor of cerebral microvascular disease, but its association with common…”
Get full text

The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas by Valencia, Karmele, Erice, Oihane, Kostyrko, Kaja, Hausmann, Simone, Guruceaga, Elizabeth, Tathireddy, Anuradha, Flores, Natasha M, Sayles, Leanne C, Lee, Alex G, Fragoso, Rita, Sun, Tian-Qiang, Vallejo, Adrian, Roman, Marta, Entrialgo-Cadierno, Rodrigo, Migueliz, Itziar, Razquin, Nerea, Fortes, Puri, Lecanda, Fernando, Lu, Jun, Ponz-Sarvise, Mariano, Chen, Chang-Zheng, Mazur, Pawel K, Sweet-Cordero, E Alejandro, Vicent, Silvestre

“…Few therapies are currently available for patients with KRAS-driven cancers, highlighting the need to identify new molecular targets that modulate central…”
Get full text