Search Results - "Vallat, Laurent"

Multi-omics dataset to decipher the complexity of drug resistance in diffuse large B-cell lymphoma by Fornecker, Luc-Matthieu, Muller, Leslie, Bertrand, Frédéric, Paul, Nicodème, Pichot, Angélique, Herbrecht, Raoul, Chenard, Marie-Pierre, Mauvieux, Laurent, Vallat, Laurent, Bahram, Seiamak, Cianférani, Sarah, Carapito, Raphaël, Carapito, Christine

“…The prognosis of patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) remains unsatisfactory and, despite major advances in genomic…”
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Molecular heterogeneity and measurable residual disease of rare NPM1 mutations in acute myeloid leukemia: a nationwide experience from the GBMHM study group by Fournier, Elise, Heiblig, Maël, Lespinasse, Christine, Flandrin-Gresta, Pascale, Geay, Antoine, Miguet, Laurent, Fenwarth, Laurene, Vallat, Laurent, Soubeyrand, Brigitte, Marceau-Renaut, Alice, Plesa, Adriana, Preudhomme, Claude, Sujobert, Pierre, Hayette, Sandrine, Duployez, Nicolas, Huet, Sarah

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BCR-associated factors driving chronic lymphocytic leukemia cells proliferation ex vivo by Schleiss, Cédric, Ilias, Wassila, Tahar, Ouria, Güler, Yonca, Miguet, Laurent, Mayeur-Rousse, Caroline, Mauvieux, Laurent, Fornecker, Luc-Matthieu, Toussaint, Elise, Herbrecht, Raoul, Bertrand, Frédéric, Maumy-Bertrand, Myriam, Martin, Thierry, Fournel, Sylvie, Georgel, Philippe, Bahram, Seiamak, Vallat, Laurent

“…A chronic antigenic stimulation is believed to sustain the leukemogenic development of chronic lymphocytic leukemia (CLL) and most of lymphoproliferative…”
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Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia by Schleiss, Cedric, Carapito, Raphael, Fornecker, Luc-Matthieu, Muller, Leslie, Paul, Nicodème, Tahar, Ouria, Pichot, Angelique, Tavian, Manuela, Nicolae, Alina, Miguet, Laurent, Mauvieux, Laurent, Herbrecht, Raoul, Cianferani, Sarah, Freund, Jean-Noel, Carapito, Christine, Maumy-Bertrand, Myriam, Bahram, Seiamak, Bertrand, Frederic, Vallat, Laurent

“…B-cell receptor (BCR) signaling is crucial for the pathophysiology of most mature B-cell lymphomas/leukemias and has emerged as a therapeutic target whose…”
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Effect of an intraoperative periradicular application of platelet-rich fibrin (PRF) on residual post-surgical neuropathic pain after disc herniation surgery: study protocol for NeuroPRF, a randomized controlled trial by Todeschi, Julien, Dannhoff, Guillaume, Coca, Andres Hugo, Timbolschi, Daniel Ionut, Proust, François, Lefebvre, François, Lelievre, Vincent, Poisbeau, Pierrick, Vallat, Laurent, Salvat, Eric, Bohren, Yohann

“…The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the recommended treatments for neuropathic pain, namely…”
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CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition by Galland, Ava, Gourain, Victor, Habbas, Karima, Güler, Yonca, Martin, Elisabeth, Ebel, Claudine, Tavian, Manuela, Vallat, Laurent, Chenard, Marie‐Pierre, Mauvieux, Laurent, Freund, Jean‐Noël, Duluc, Isabelle, Domon‐Dell, Claire

“…The intestine‐specific caudal‐related homeobox gene‐2 (CDX2) homeobox gene, while being a tumor suppressor in the gut, is ectopically expressed in a large…”
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Multiomics of three hematological malignancies in a patient reveal their origin from clonal hematopoietic stem cells by Mayeur, Sylvain, Molitor, Anne, Miguet, Laurent, Rigolot, Lucie, Naegely, Lydie, Stemmelen, Tristan, Meyer, Sébastien, Toussaint, Elise, Vallat, Laurent, Eischen, Alice, Chenard, Marie-Pierre, Tavian, Manuela, Bahram, Seiamak, Carapito, Raphael, Nicolae, Alina

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Temporal genetic program following B-cell receptor cross-linking: altered balance between proliferation and death in healthy and malignant B cells by Vallat, Laurent D., Park, Yuhyun, Li, Cheng, Gribben, John G.

“…Gene expression in cells is a dynamic process but is usually examined at a single time point. We used gene expression profiling over time to build temporal…”
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Reduced DICER1 Expression Bestows Rheumatoid Arthritis Synoviocytes Proinflammatory Properties and Resistance to Apoptotic Stimuli by Alsaleh, Ghada, Nehmar, Ramzi, Blüml, Stephan, Schleiss, Cédric, Ostermann, Eleonore, Dillenseger, Jean‐Philippe, Sayeh, Amira, Choquet, Philippe, Dembele, Doulaye, Francois, Antoine, Salmon, Jean‐Hugues, Paul, Nicodème, Schabbauer, Gernot, Bierry, Guillaume, Meyer, Alain, Gottenberg, Jacques‐Eric, Haas, Gabrielle, Pfeffer, Sebastien, Vallat, Laurent, Sibilia, Jean, Bahram, Seiamak, Georgel, Philippe

“…Objective While the regulatory role of individual microRNAs (miRNAs) in rheumatoid arthritis (RA) is well established, the role of DICER1 in the pathogenesis…”
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Reverse-engineering the genetic circuitry of a cancer cell with predicted intervention in chronic lymphocytic leukemia by Vallat, Laurent, Kemper, Corey A., Jung, Nicolas, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Meyer, Nicolas, Pocheville, Arnaud, Fisher, John W., Gribben, John G., Bahram, Seiamak

“…Cellular behavior is sustained by genetic programs that are progressively disrupted in pathological conditions—notably, cancer. High-throughput gene expression…”
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Expression and proliferative effect of hemokinin-1 in human B-cells by Grassin-Delyle, Stanislas, Buenestado, Amparo, Vallat, Laurent, Naline, Emmanuel, Marx, Sirima, Decocq, Julie, Debré, Patrice, Bernard, Olivier A., Advenier, Charles, Devillier, Philippe, Merle-Béral, Hélène

“…► Human hemokinin-1 and NK 1-receptor are expressed in human B-cells. ► Their expression is affected in B-cells from human malignancies. ► Hemokinin-1 affects…”
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Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males by Marteau, Jean-Brice, Rigaud, Odile, Brugat, Thibaut, Gault, Nathalie, Vallat, Laurent, Kruhoffer, Mogens, Orntoft, Torben F, Nguyen-Khac, Florence, Chevillard, Sylvie, Merle-Beral, Hélène, Delic, Jozo

“…The sensitivity of chronic lymphocytic leukemia (CLL) cells to current treatments, both in vitro and in vivo, relies on their ability to activate apoptotic…”
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MultiRNAflow: integrated analysis of temporal RNA-seq data with multiple biological conditions by Loubaton, Rodolphe, Champagnat, Nicolas, Vallois, Pierre, Vallat, Laurent

“…Abstract Motivation The dynamic transcriptional mechanisms that govern eukaryotic cell function can now be analyzed by RNA sequencing. However, the packages…”
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selectBoost: a general algorithm to enhance the performance of variable selection methods by Bertrand, Frédéric, Aouadi, Ismaïl, Jung, Nicolas, Carapito, Raphael, Vallat, Laurent, Bahram, Seiamak, Maumy-Bertrand, Myriam

“…Abstract Motivation With the growth of big data, variable selection has become one of the critical challenges in statistics. Although many methods have been…”
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Molecular Mechanism of EGFR-TKI Resistance in EGFR -Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring by Reita, Damien, Pabst, Lucile, Pencreach, Erwan, Guérin, Eric, Dano, Laurent, Rimelen, Valérie, Voegeli, Anne-Claire, Vallat, Laurent, Mascaux, Céline, Beau-Faller, Michèle

“…Non-small cell lung cancer (NSCLC) is the most common cancer in the world. Activating epidermal growth factor receptor ( ) gene mutations are a positive…”
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Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance by Reita, Damien, Pabst, Lucile, Pencreach, Erwan, Guérin, Eric, Dano, Laurent, Rimelen, Valérie, Voegeli, Anne-Claire, Vallat, Laurent, Mascaux, Céline, Beau-Faller, Michèle

“…KRAS is the most frequently mutated oncogene in non-small cell lung cancers (NSCLC), with a frequency of around 30%, and encoding a GTPAse that cycles between…”
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Differential Phosphoproteomics Deciphers Physiopathology of High-Risk Mantle Cell Lymphoma by Fuseau, Charline, Baldacini, Mathieu, Nicolae, Alina, Miguet, Laurent, Mauvieux, Laurent, Vallat, Laurent, Domon-Dell, Claire, Tavian, Manuela, Freund, Jean-Noel, Cianferani, Sarah, Schaeffer-Reiss, Christine, Fornecker, Luc-Matthieu, Rolland, Delphine C.M.

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Association Between Bruton's Tyrosine Kinase Gene Overexpression and Risk of Lymphoma in Primary Sjögren's Syndrome by Duret, Pierre-Marie, Schleiss, Cedric, Kawka, Lou, Meyer, Nicolas, Ye, Tao, Saraux, Alain, Devauchelle-Pensec, Valérie, Seror, Raphaele, Larroche, Claire, Perdriger, Aleth, Sibilia, Jean, Vallat, Laurent, Fornecker, Luc-Matthieu, Nocturne, Gaetane, Mariette, Xavier, Gottenberg, Jacques-Eric

“…We undertook this study to analyze whole blood gene expression and to investigate the role of B cell genes in primary Sjögren's syndrome-related non-Hodgkin…”
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Targeted Mutation Analysis of Acute Myeloid Leukemia at Diagnosis and Relapse Shows Different Clonal Evolution Patterns Involving Different Functional Classes of Genes by Grandpré, Nicolas, Miguet, Laurent, Ittel, Antoine, Gervais, Carine, Jeandidier, Eric, Vallat, Laurent Daniel, Mauvieux, Laurent

“…AML relapse is often associated with a clonal evolution at the cytogenetic and molecular level and therefore represents a challenge for the treatment. Targeted…”
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Spleen Tyrosine Kinase Is Overexpressed and Represents a Potential Therapeutic Target in Chronic Lymphocytic Leukemia by BUCHNER, Maike, FUCKS, Simon, JUMAA, Hassan, VEELKEN, Hendrik, DIERKS, Christine, ZIRLIK, Katja, PRINZ, Gabriele, PFEIFER, Dietmar, BARTHOLOME, Kilian, BURGER, Meike, CHEVALIER, Nina, VARAT, Laurent, TIMMER, Jens, GRIBBEN, John G

“…B-cell receptor signaling contributes to apoptosis resistance in chronic lymphocytic leukemia (CLL), limiting the efficacy of current therapeutic approaches…”
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