Search Results - "Valko, K."

Chromatographic Hydrophobicity Index by Fast-Gradient RP-HPLC:  A High-Throughput Alternative to log P/log D by Valkó, Klára, Bevan, Chris, Reynolds, Derek

“…A new chromatographic hydrophobicity index (CHI) is described which can be used as part of a protocol for high-throughput (50−100 compounds/day)…”
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Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention and a hydrogen bond acidity term (zetaalpha(2)(H)) by Valko, K, My Du, C, Bevan, C, Reynolds, D P, Abraham, M H

“…We propose a rapid method for the measurement of octanol/water partition coefficients (log P(oct)) via fast gradient reversed phase retention and the…”
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Retention of Ionizable Compounds on HPLC. 8. Influence of Mobile-Phase pH Change on the Chromatographic Retention of Acids and Bases during Gradient Elution by Canals, Immaculada, Valkó, Klára, Bosch, Elisabeth, Hill, Alan P, Rosés, Martí

“…The relationships between retention and mobile-phase pH in gradient elution are studied for acids and bases. The apparent pH shift caused by the increasing…”
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A cell-based approach for the early assessment of the phospholipidogenic potential in pharmaceutical research and drug development by CASARTELLI, A, BONATO, M, CRISTOFORI, P, CRIVELLENTE, F, DAL NEGRO, G, MASOTTO, I, MUTINELLI, C, VALKO, K, BONFANTE, V

“…Phospholipidosis is a term commonly used to indicate a phospholipid storage disorder; in affected cells, phospholipids accumulate in lysosomes that acquire a…”
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Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution by VALKO, Klara

“…Octanol–water partition coefficients are the most widely used measure of lipophilicity in modelling biological partition/distribution. It has long been…”
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Characterizing the Selectivity of Stationary Phases and Organic Modifiers in Reversed-Phase High-Performance Liquid Chromatographic Systems by a General Solvation Equation Using Gradient Elution by Du, Chau My, Valko, Klara, Bevan, Chris, Reynolds, Derek, Abraham, Michael H.

“…Retention data for a set of 69 compounds using rapid gradient elution are obtained on a wide range of reversed-phase stationary phases and organic modifiers…”
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Relationships between the chromatographic hydrophobicity indices and solute descriptors obtained by using several reversed-phase, diol, nitrile, cyclodextrin and immobilised artificial membrane-bonded high-performance liquid chromatography columns by Valkó, K, Plass, M, Bevan, C, Reynolds, D, Abraham, M.H

“…The solvation equation [Eq. (1)] can be applied to reversed-phase HPLC capacity factors (i.e. logSP=logk).(1)logSP=c+rR2+sπH2+aΣαH2+bΣβH2+vVxS.SP is a solute…”
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Fast gradient HPLC method to determine compounds binding to human serum albumin. Relationships with octanol/water and immobilized artificial membrane lipophilicity by Valko, Klara, Nunhuck, Shenaz, Bevan, Chris, Abraham, Michael H, Reynolds, Derek P

“…A fast gradient HPLC method (cycle time 15 min) has been developed to determine Human Serum Albumin (HSA) binding of discovery compounds using chemically…”
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Unique selectivity of perfluorinated stationary phases with 2,2,2-trifluoroethanol as organic mobile phase modifier by Valkó, K, Espinosa, S, Du, C.M, Bosch, E, Rosés, M, Bevan, C, Abraham, M.H

“…The selectivity of Luna C 18, Xterra™ C 18 and Fluophase (perfluorinated C 6) stationary phases has been investigated with aqueous acetonitrile, methanol and…”
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Estimation of Volume of Distribution in Humans from High Throughput HPLC-Based Measurements of Human Serum Albumin Binding and Immobilized Artificial Membrane Partitioning by Hollósy, Ferenc, Valkó, Klára, Hersey, Anne, Nunhuck, Shenaz, Kéri, György, Bevan, Chris

“…The volume of distribution (VD) in humans of 179 known drug molecules (acids, bases, and neutrals) has been modeled using two biomimetic-binding measurements…”
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Microwave extraction. A novel sample preparation method for chromatography by Ganzler, K, Salgó, A, Valkó, K

“…The applicability of microwave irradiation to the extraction of various types of compounds from soil, seeds, foods and feeds as a novel sample preparation…”
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Nitric oxide effects on polyamine pathways in cultured hepatocytes by Anderson, M M, Ast, T, Nicolaou, A, Valko, K, Gibbons, W A

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Rapid-gradient HPLC method for measuring drug interactions with immobilized artificial membrane: comparison with other lipophilicity measures by Valko, K, Du, C M, Bevan, C D, Reynolds, D P, Abraham, M H

“…A fast-gradient high-performance liquid chromatographic (HPLC) method has been suggested to characterize the interactions of drugs with an immobilized…”
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Rapid Gradient RP-HPLC Method for Lipophilicity Determination:  A Solvation Equation Based Comparison with Isocratic Methods by Du, Chau My, Valko, Klara, Bevan, Chris, Reynolds, Derek, Abraham, Michael H

“…The chromatographic hydrophobicity index (CHI) obtained from high-throughput gradient elution reversed-phase HPLC with ODS column and acetonitrile mobile phase…”
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Change of mobile phase pH during gradient reversed-phase chromatography with 2,2,2-trifluoroethanol–water as mobile phase and its effect on the chromatographic hydrophobicity index determination by Espinosa, Sonia, Bosch, Elisabeth, Rosés, Martı́, Valkó, Klára

“…We have shown previously that using a trifluoroethanol containing mobile phase provides a unique chromatographic selectivity. This is essential to derive…”
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Binding measurements of indolocarbazole derivatives to immobilised human serum albumin by high-performance liquid chromatography by Ashton, D.S., Beddell, C.R., Cockerill, G.S., Gohil, K., Gowrie, C., Robinson, J.E., Slater, M.J., Valko, K.

“…The binding properties of six indolocarbazole derivatives have been measured using immobilised human serum albumin (HSA) in an HPLC column. The compounds…”
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Quantitative structure-retention relationships of acyclovir esters using immobilised albumin high-performance liquid chromatography and reversed-phase high-performance liquid chromatography by Ashton, D.S., Beddell, C., Ray, A.D., Valkó, K.

“…Acyclovir and 18 of its esters have been investigated by systematic measurement of their reversed-phase high-performance liquid chromatographic retention using…”
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Determination of solute descriptors of tripeptide derivatives based on high-throughput gradient high-performance liquid chromatography retention data by Plass, Monika, Valko, Klara, Abraham, Michael H

“…Recently proposed chromatographic hydrophobicity indices (CHIs) have been calculated from the correlation of fast gradient HPLC retention times with ϕ 0 values…”
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Structure-activity relationships of new muscarinergic dibenzodioxazocines by Kálmán, A, Párkányi, L, Valkó, K, Mátrai, G, Batke, J, Gaál, J

“…1H-NMR and X-ray conformation studies of new muscarinergic dibenzodioxazocines have been carried out. It is suggested that EGYT-2347…”
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A technique for intra-articular injection of the equine tarsometatarsal joint by Brown, M P, Valko, K

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