Search Results - "Valkama, J."

Development of Large-Scale Downstream Processing for Lentiviral Vectors by Valkama, Anniina J., Oruetxebarria, Igor, Lipponen, Eevi M., Leinonen, Hanna M., Käyhty, Piia, Hynynen, Heidi, Turkki, Vesa, Malinen, Joonas, Miinalainen, Tuukka, Heikura, Tommi, Parker, Nigel R., Ylä-Herttuala, Seppo, Lesch, Hanna P.

“…The interest in lentiviral vectors (LVs) has increased prominently for gene therapy applications, but few have reached the later stages of clinical trials. The…”
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Evaluation of artificial nests as a conservation tool for three forest-dwelling raptors by Björklund, H., Valkama, J., Saurola, P., Laaksonen, T.

“…Forest age structure has become younger and the amount of old forest has decreased due to intensive forestry in Northern Europe. Consequently, large…”
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Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells by Leinonen, Hanna M., Lipponen, Eevi M., Valkama, Anniina J., Hynynen, Heidi, Oruetxebarria, Igor, Turkki, Vesa, Olsson, Venla, Kurkipuro, Jere, Samaranayake, Haritha, Määttä, Ann-Marie, Parker, Nigel R., Ylä-Herttuala, Seppo, Lesch, Hanna P.

“…The therapeutic efficacy of a lentiviral vector (LV) expressing the herpes simplex virus thymidine kinase (HSV-TK) was studied in an immunocompetent rat…”
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Corrigendum: Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy by Eriksson, Reetta A E, Nieminen, Tiina, Galibert, Lionel, Peltola, Sanna K, Tikkanen, Petra, Käyhty, Piia, Leinonen, Hanna M, Oruetxebarria, Igor, Lepola, Saana, Valkama, Anniina J, Lipponen, Eevi M, Lesch, Hanna P, Ylä-Herttuala, Seppo, Airenne, Kari J

“…[This corrects the article DOI: 10.3389/fmed.2022.1052318.]…”
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Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo by Menne, J., Meier, M., Park, J.-K., Boehne, M., Kirsch, T., Lindschau, C., Ociepka, R., Leitges, M., Rinta-Valkama, J., Holthofer, H., Haller, H.

“…Albuminuria in diabetic nephropathy is due to endothelial dysfunction, a loss of negative charges in the basement membrane, and changes a of the slit-membrane…”
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Impact of Climatic Factors on the Developmental Stability of Mountain Birch Growing in a Contaminated Area by Valkama, Jari, Kozlov, Mikhail V.

“…1. We examined developmental stability in mountain birch Betula pubescens ssp. czerepanovii along a strong pollution gradient in the Kola Peninsula,…”
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Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor by Valkama, A J, Leinonen, H M, Lipponen, E M, Turkki, V, Malinen, J, Heikura, T, Ylä-Herttuala, S, Lesch, H P

“…Lentiviral vectors (LVs) are promising tools for gene therapy. However, scaling up the production methods of LVs in order to produce high-quality vectors for…”
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Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy by Eriksson, Reetta A E, Nieminen, Tiina, Galibert, Lionel, Peltola, Sanna K, Tikkanen, Petra, Käyhty, Piia, Lesch, Hanna P, Ylä-Herttuala, Seppo, Airenne, Kari J

“…Gene therapy would greatly benefit from a method to regulate therapeutic gene expression temporally. Riboswitches are small RNA elements that have been studied…”
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Nephrin in human lymphoid tissues by Aström, E, Rinta-Valkama, J, Gylling, M, Ahola, H, Miettinen, A, Timonen, T, Holthöfer, H

“…When nephrin, the protein product of NPHS1, was cloned, it was proposed to be specific for the kidney glomerular podocytes. Recently, however, new reports have…”
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Diet quality as assessed by the Healthy Food Intake Index and relationship with serum lipoprotein particles and serum fatty acids in pregnant women at increased risk for gestational diabetes by Valkama, Anita J., Meinilä, Jelena M., Koivusalo, Saila B., Lindström, Jaana, Rönö, Kristiina, Stach-Lempinen, Beata, Eriksson, Johan G.

“…The importance of overall diet in modifying circulating lipoprotein particles and fatty acids during pregnancy is unclear. We examined the relationships of…”
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Spatial Variation of Trichinella Prevalence in Rats in Finnish Waste Disposal Sites by Mikkonen, T, Valkama, J, Wihlman, H, Sukura, A

“…Trichinellosis is 1 of the most widespread parasitic zoonoses in the world and can be lethal to humans. Trichinella spp. are also parasites of considerable…”
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Frequency domain measures of heart rate variability before the onset of nonsustained and sustained ventricular tachycardia in patients with coronary artery disease by HUIKURI, H. V, VALKAMA, J. O, JUHANI AIRAKSINEN, K. E, SEPPÄNEN, T, KESSLER, K. M, TAKKUNEN, J. T, MYERBURG, R. J

“…Low heart rate variability (HRV) is associated with an increased risk of arrhythmic death and ventricular tachycardia (VT). The purpose of this study was to…”
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Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women by Valkama, Anita J, Meinilä, Jelena M, Koivusalo, Saila B, Lindström, Jaana, Rönö, Kristiina, Tiitinen, Aila E, Stach-Lempinen, Beata, Kautiainen, Hannu J, Viljakainen, Heli, Andersson, Sture, Eriksson, Johan G

“…Obesity increases the risk of low 25-hydroxyvitamin D (25(OH)D) concentrations and gestational diabetes (GDM). We explored whether the association between GDM…”
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Limited effects of heavy metal pollution on foraging and breeding success in the curlew ( Numenius arquata) by Currie, D., Valkama, J.

“…We examined the effect of heavy metal pollution on the foraging success and breeding performance of the curlew ( Numenius arquata) along a documented pollution…”
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The effect of pre‐pregnancy lifestyle counselling on food intakes and association between food intakes and gestational diabetes in high‐risk women: results from a randomised controlled trial by Valkama, A. J., Meinilä, J., Koivusalo, S., Lindström, J., Rönö, K., Stach‐Lempinen, B., Kautiainen, H., Eriksson, J. G.

“…Background Healthy diets before and during pregnancy have been suggested to reduce the risk of gestational diabetes (GDM). Several lifestyle intervention…”
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Analytical performance of time-resolved fluorometry-based Innotrac Aio!™ cardiac marker immunoassays by HEDBERG, P., VALKAMA, J., PUUKKA, M.

“…The results of an evaluation of the Innotrac Aio!™ cardiac markers are presented. This system is based on dry-chemistry, time-resolved fluorometry. All…”
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Nestbox characteristics, habitat quality and reproductive success of Eurasian Kestrels by Valkama, J., Korpimäki, E.

“…We studied nestbox selection, habitat quality and reproductive success of Eurasian Kestrels Falco tinnunculus during 1985-95 in western Finland. Nestboxes were…”
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Usability of citizen science observations together with airborne laser scanning data in determining the habitat preferences of forest birds by Mononen, L., Auvinen, A.-P., Packalen, P., Virkkala, R., Valbuena, R., Bohlin, I., Valkama, J., Vihervaara, P.

“…•Citizen science (CS) complements necessary field work in bird ecology.•Airborne Laser Scanning (ALS) increases the level of detail in analysing…”
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Survival fluctuation is linked to precipitation variation during staging in a migratory shorebird by Brlík, Vojtěch, Pakanen, Veli-Matti, Jaakkonen, Tuomo, Arppe, Heikki, Jokinen, Jaakko, Lakka, Johanna, Blomqvist, Donald, Hahn, Steffen, Valkama, Jari, Koivula, Kari

“…Understanding how weather conditions affect animal populations is essential to foresee population changes in times of global climate shifts. However, assessing…”
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Higher CK-MB mass values in heparin plasma than in serum measured with the Abbott AxSYM system by Hedberg, P, Melkko, T, Valkama, J, Puukka, M

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