Search Results - "Valk, Peter J."

Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value by Abbas, Saman, Lugthart, Sanne, Kavelaars, François G., Schelen, Anita, Koenders, Jasper E., Zeilemaker, Annelieke, van Putten, Wim J.L., Rijneveld, Anita W., Löwenberg, Bob, Valk, Peter J.M.

“…Somatic mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) were recently demonstrated in acute myeloid leukemia (AML), but their prevalence and…”
Get full text

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia by Ribeiro, Ana Flávia Tibúrcio, Pratcorona, Marta, Erpelinck-Verschueren, Claudia, Rockova, Veronika, Sanders, Mathijs, Abbas, Saman, Figueroa, Maria E., Zeilemaker, Annelieke, Melnick, Ari, Löwenberg, Bob, Valk, Peter J.M., Delwel, Ruud

“…The prevalence, the prognostic effect, and interaction with other molecular markers of DNMT3A mutations was studied in 415 patients with acute myeloid leukemia…”
Get full text

MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia by Jongen-Lavrencic, Mojca, Sun, Su Ming, Dijkstra, Menno K., Valk, Peter J.M., Löwenberg, Bob

“…Acute myeloid leukemia (AML) is a highly diverse disease characterized by various cytogenetic and molecular abnormalities. MicroRNAs are small noncoding RNAs…”
Get full text

Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity by Taskesen, Erdogan, Bullinger, Lars, Corbacioglu, Andrea, Sanders, Mathijs A., Erpelinck, Claudia A.J., Wouters, Bas J., van der Poel-van de Luytgaarde, Sonja C., Damm, Frederik, Krauter, Jürgen, Ganser, Arnold, Schlenk, Richard F., Löwenberg, Bob, Delwel, Ruud, Döhner, Hartmut, Valk, Peter J.M., Döhner, Konstanze

“…We evaluated concurrent gene mutations, clinical outcome, and gene expression signatures of CCAAT/enhancer binding protein alpha (CEBPA) double mutations…”
Get full text

Molecular characterization of mutant TP53 acute myeloid leukemia and high-risk myelodysplastic syndrome by Grob, Tim, Al Hinai, Adil S.A., Sanders, Mathijs A., Kavelaars, François G., Rijken, Melissa, Gradowska, Patrycja L., Biemond, Bart J., Breems, Dimitri A., Maertens, Johan, van Marwijk Kooy, Marinus, Pabst, Thomas, de Weerdt, Okke, Ossenkoppele, Gert J., van de Loosdrecht, Arjan A., Huls, Gerwin A., Cornelissen, Jan J., Beverloo, H. Berna, Löwenberg, Bob, Jongen-Lavrencic, Mojca, Valk, Peter J.M.

“…Substantial heterogeneity within mutant TP53 acute myeloid leukemia (AML) and myelodysplastic syndrome with excess of blast (MDS-EB) precludes the exact…”
Get full text

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia by Figueroa, Maria E., Lugthart, Sanne, Li, Yushan, Erpelinck-Verschueren, Claudia, Deng, Xutao, Christos, Paul J., Schifano, Elizabeth, Booth, James, van Putten, Wim, Skrabanek, Lucy, Campagne, Fabien, Mazumdar, Madhu, Greally, John M., Valk, Peter J.M., Löwenberg, Bob, Delwel, Ruud, Melnick, Ari

“…We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined…”
Get full text

Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia by Beekman, Renée, Valkhof, Marijke G., Sanders, Mathijs A., van Strien, Paulette M.H., Haanstra, Jurgen R., Broeders, Lianne, Geertsma-Kleinekoort, Wendy M., Veerman, Anjo J.P., Valk, Peter J.M., Verhaak, Roel G., Löwenberg, Bob, Touw, Ivo P.

“…Severe congenital neutropenia (SCN) is a BM failure syndrome with a high risk of progression to acute myeloid leukemia (AML). The underlying genetic changes…”
Get full text

High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated by Lugthart, Sanne, van Drunen, Ellen, van Norden, Yvette, van Hoven, Antoinette, Erpelinck, Claudia A.J., Valk, Peter J.M., Beverloo, H. Berna, Löwenberg, Bob, Delwel, Ruud

“…Inappropriate expression of EVI1 (ecotropic virus integration-1), in particular splice form EVI1-1D, through chromosome 3q26 lesions or other mechanisms has…”
Get full text

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern by Hollink, Iris H.I.M., van den Heuvel-Eibrink, Marry M., Arentsen-Peters, Susan T.C.J.M., Pratcorona, Marta, Abbas, Saman, Kuipers, Jenny E., van Galen, Janneke F., Beverloo, H. Berna, Sonneveld, Edwin, Kaspers, Gert-Jan J.L., Trka, Jan, Baruchel, Andre, Zimmermann, Martin, Creutzig, Ursula, Reinhardt, Dirk, Pieters, Rob, Valk, Peter J.M., Zwaan, C. Michel

“…Translocations involving nucleoporin 98kD (NUP98) on chromosome 11p15 occur at relatively low frequency in acute myeloid leukemia (AML) but can be missed with…”
Get full text

Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1 by Lugthart, Sanne, Figueroa, Maria E., Bindels, Eric, Skrabanek, Lucy, Valk, Peter J.M., Li, Yushan, Meyer, Stefan, Erpelinck-Verschueren, Claudia, Greally, John, Löwenberg, Bob, Melnick, Ari, Delwel, Ruud

“…DNA methylation patterns are frequently dysregulated in cancer, although little is known of the mechanisms through which specific gene sets become aberrantly…”
Get full text

MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome by Stavropoulou, Vaia, Kaspar, Susanne, Brault, Laurent, Sanders, Mathijs A., Juge, Sabine, Morettini, Stefano, Tzankov, Alexandar, Iacovino, Michelina, Lau, I-Jun, Milne, Thomas A., Royo, Hélène, Kyba, Michael, Valk, Peter J.M., Peters, Antoine H.F.M., Schwaller, Juerg

“…To address the impact of cellular origin on acute myeloid leukemia (AML), we generated an inducible transgenic mouse model for MLL-AF9-driven leukemia. MLL-AF9…”
Get full text

Archived bone marrow smears are an excellent source for NGS-based mutation detection in acute myeloid leukemia by Al Hinai, Adil S. A., Grob, Tim, Kavelaars, François G., Rijken, Melissa, Zeilemaker, Annelieke, Erpelinck-Verschueren, Claudia A. J., Gussinklo, Kirsten J., Sanders, Mathijs A., van Lom, Kirsten, Valk, Peter J. M.

Get full text

Review: Aberrant EVI1 expression in acute myeloid leukaemia by Hinai, Adil A., Valk, Peter J. M.

“…Summary Deregulated expression of the ecotropic virus integration site 1 (EVI1) gene is the molecular hallmark of therapy‐resistant myeloid malignancies…”
Get full text

Rearrangements involving 11q23.3/KMT2A in adult AML: mutational landscape and prognostic implications – a HARMONY study by Hernández-Sánchez, Alberto, González, Teresa, Sobas, Marta, Sträng, Eric, Castellani, Gastone, Abáigar, María, Valk, Peter J. M., Villaverde Ramiro, Ángela, Benner, Axel, Metzeler, Klaus H., Azibeiro, Raúl, Tettero, Jesse M., Martínez-López, Joaquín, Pratcorona, Marta, Martínez Elicegui, Javier, Mills, Ken I., Thiede, Christian, Sanz, Guillermo, Döhner, Konstanze, Heuser, Michael, Haferlach, Torsten, Turki, Amin T., Reinhardt, Dirk, Schulze-Rath, Renate, Barbus, Martje, Hernández-Rivas, Jesús María, Huntly, Brian, Ossenkoppele, Gert, Döhner, Hartmut, Bullinger, Lars

“…Balanced rearrangements involving the KMT2A gene ( KMT2A r) are recurrent genetic abnormalities in acute myeloid leukemia (AML), but there is lack of consensus…”
Get full text

Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML by Li, Zejuan, Huang, Hao, Li, Yuanyuan, Jiang, Xi, Chen, Ping, Arnovitz, Stephen, Radmacher, Michael D., Maharry, Kati, Elkahloun, Abdel, Yang, Xinan, He, Chunjiang, He, Miao, Zhang, Zhiyu, Dohner, Konstanze, Neilly, Mary Beth, Price, Colles, Lussier, Yves A., Zhang, Yanming, Larson, Richard A., Le Beau, Michelle M., Caligiuri, Michael A., Bullinger, Lars, Valk, Peter J.M., Delwel, Ruud, Lowenberg, Bob, Liu, Paul P., Marcucci, Guido, Bloomfield, Clara D., Rowley, Janet D., Chen, Jianjun

“…Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute…”
Get full text

Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia by Rapaport, Franck, Neelamraju, Yaseswini, Baslan, Timour, Hassane, Duane, Gruszczynska, Agata, Robert de Massy, Marc, Farnoud, Noushin, Haddox, Samuel, Lee, Tak, Medina-Martinez, Juan, Sheridan, Caroline, Thurmond, Alexis, Becker, Michael, Bekiranov, Stefan, Carroll, Martin, Moses Murdock, Heardly, Valk, Peter J. M., Bullinger, Lars, D’Andrea, Richard, Lowe, Scott W., Neuberg, Donna, Levine, Ross L., Melnick, Ari, Garrett-Bakelman, Francine E.

Get full text

Risk stratification of intermediate-risk acute myeloid leukemia: integrative analysis of a multitude of gene mutation and gene expression markers by Rockova, Veronika, Abbas, Saman, Wouters, Bas J., Erpelinck, Claudia A.J., Beverloo, H. Berna, Delwel, Ruud, van Putten, Wim L.J., Löwenberg, Bob, Valk, Peter J.M.

“…Numerous molecular markers have been recently discovered as potential prognostic factors in acute myeloid leukemia (AML). It has become of critical importance…”
Get full text

PPM1D mutations appear in complete remission after exposure to chemotherapy without predicting emerging AML relapse by Al Hinai, Adil S. A., Grob, Tim, Rijken, Melissa, Kavelaars, François G., Zeilemaker, Annelieke, Erpelinck-Verschueren, Claudia A. J., Sanders, Mathijs A., Löwenberg, Bob, Jongen-Lavrencic, Mojca, Valk, Peter J. M.

Get full text

Acquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic value by Pratcorona, M., Abbas, S., Sanders, M. A., Koenders, J. E., Kavelaars, F. G., Erpelinck-Verschueren, C. A. J., Zeilemakers, A., Lowenberg, B., Valk, P. J. M.

“…Somatic mutations in the additional sex comb-like 1 (ASXL1) gene have been described in various types of myeloid malignancies, including acute myeloid…”
Get full text

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling by Verhaak, Roel G.W, Wouters, Bas J, Erpelinck, Claudia A.J, Abbas, Saman, Beverloo, H. Berna, Lugthart, Sanne, Lowenberg, Bob, Delwel, Ruud, Valk, Peter J.M

“…1 Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands 2 Department of Medical Oncology, Dana-Farber Cancer Institute,…”
Get full text