Search Results - "Valimaki, Katja"

Systems pathology by multiplexed immunohistochemistry and whole-slide digital image analysis by Blom, Sami, Paavolainen, Lassi, Bychkov, Dmitrii, Turkki, Riku, Mäki-Teeri, Petra, Hemmes, Annabrita, Välimäki, Katja, Lundin, Johan, Kallioniemi, Olli, Pellinen, Teijo

“…The paradigm of molecular histopathology is shifting from a single-marker immunohistochemistry towards multiplexed detection of markers to better understand…”
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Prognostic Role of Tumor Immune Microenvironment in Pleural Epithelioid Mesothelioma by Ollila, Hely, Mäyränpää, Mikko I., Paavolainen, Lassi, Paajanen, Juuso, Välimäki, Katja, Sutinen, Eva, Wolff, Henrik, Räsänen, Jari, Kallioniemi, Olli, Myllärniemi, Marjukka, Ilonen, Ilkka, Pellinen, Teijo

“…Background Pleural mesothelioma (MPM) is an aggressive malignancy with an average patient survival of only 10 months. Interestingly, about 5%–10% of the…”
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ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneity by Piki, Emilia, Dini, Alice, Raivola, Juuli, Salokas, Kari, Zhang, Kaiyang, Varjosalo, Markku, Pellinen, Teijo, Välimäki, Katja, Veskimäe, Kristina Tabor, Staff, Synnöve, Hautaniemi, Sampsa, Murumägi, Astrid, Ungureanu, Daniela

“…Wnt pathway dysregulation through genetic and non-genetic alterations occurs in multiple cancers, including ovarian cancer (OC). The aberrant expression of the…”
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High-throughput ex vivo drug testing identifies potential drugs and drug combinations for NRAS-positive malignant melanoma by Kohtamäki, Laura, Arjama, Mariliina, Mäkelä, Siru, Ianevski, Philipp, Välimäki, Katja, Juteau, Susanna, Ilmonen, Suvi, Ungureanu, Daniela, Kallioniemi, Olli, Murumägi, Astrid, Hernberg, Micaela

“…•We established patient-derived cancer cell (PDC) lines from NRAS-positive MM tumors.•We carried out high-throughput drug testing with PDCs against 527…”
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Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival by Brück, Oscar, Dufva, Olli, Hohtari, Helena, Blom, Sami, Turkki, Riku, Ilander, Mette, Kovanen, Panu, Pallaud, Celine, Ramos, Pedro Marques, Lähteenmäki, Hanna, Välimäki, Katja, El Missiry, Mohamed, Ribeiro, Antonio, Kallioniemi, Olli, Porkka, Kimmo, Pellinen, Teijo, Mustjoki, Satu

“…The immunologic microenvironment in various solid tumors is aberrant and correlates with clinical survival. Here, we present a comprehensive analysis of the…”
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High tumor cell platelet‐derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma by Ollila, Hely, Paajanen, Juuso, Wolff, Henrik, Ilonen, Ilkka, Sutinen, Eva, Välimäki, Katja, Östman, Arne, Anttila, Sisko, Kettunen, Eeva, Räsänen, Jari, Kallioniemi, Olli, Myllärniemi, Marjukka, Mäyränpää, Mikko I, Pellinen, Teijo

“…Malignant pleural mesothelioma (MPM) has a rich stromal component containing mesenchymal fibroblasts. However, the properties and interplay of MPM tumor cells…”
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Combined epithelial marker analysis of tumour budding in stage II colorectal cancer by Slik, Khadija, Blom, Sami, Turkki, Riku, Välimäki, Katja, Kurki, Samu, Mustonen, Harri, Haglund, Caj, Carpén, Olli, Kallioniemi, Olli, Korkeila, Eija, Sundström, Jari, Pellinen, Teijo

“…Tumour budding predicts survival of stage II colorectal cancer (CRC) and has been suggested to be associated with epithelial‐to‐mesenchymal transition (EMT)…”
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Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma by Murumägi, Astrid, Ungureanu, Daniela, Khan, Suleiman, Arjama, Mariliina, Välimäki, Katja, Ianevski, Aleksandr, Ianevski, Philipp, Bergström, Rebecka, Dini, Alice, Kanerva, Anna, Koivisto-Korander, Riitta, Tapper, Johanna, Lassus, Heini, Loukovaara, Mikko, Mägi, Andrus, Hirasawa, Akira, Aoki, Daisuke, Pietiäinen, Vilja, Pellinen, Teijo, Bützow, Ralf, Aittokallio, Tero, Kallioniemi, Olli

“…Many efforts are underway to develop novel therapies against the aggressive high-grade serous ovarian cancers (HGSOCs), while our understanding of treatment…”
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Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features by Pellinen, Teijo, Paavolainen, Lassi, Martín-Bernabé, Alfonso, Papatella Araujo, Renata, Strell, Carina, Mezheyeuski, Artur, Backman, Max, La Fleur, Linnea, Brück, Oscar, Sjölund, Jonas, Holmberg, Erik, Välimäki, Katja, Brunnström, Hans, Botling, Johan, Moreno-Ruiz, Pablo, Kallioniemi, Olli, Micke, Patrick, Östman, Arne

“…Cancer-associated fibroblasts (CAFs) are molecularly heterogeneous mesenchymal cells that interact with malignant cells and immune cells and confer anti- and…”
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E‐cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora, and HSP90 in preclinical models by Bruun, Jarle, Eide, Peter W., Bergsland, Christian Holst, Bruck, Oscar, Svindland, Aud, Arjama, Mariliina, Välimäki, Katja, Bjørnslett, Merete, Guren, Marianne G., Kallioniemi, Olli, Nesbakken, Arild, Lothe, Ragnhild A., Pellinen, Teijo

“…Cell–cell and cell–matrix adhesion proteins that have been implicated in colorectal epithelial integrity and epithelial‐to‐mesenchymal transition could be…”
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Enhancing T-cell recruitment in renal cell carcinoma with cytokine-armed adenoviruses by Feodoroff, Michaela, Hamdan, Firas, Antignani, Gabriella, Feola, Sara, Fusciello, Manlio, Russo, Salvatore, Chiaro, Jacopo, Välimäki, Katja, Pellinen, Teijo, Branca, Rui M, Lehtiö, Janne, D Alessio, Federica, Bottega, Paolo, Stigzelius, Virpi, Sandberg, Janita, Clancy, Jonna, Partanen, Jukka, Malmstedt, Minna, Rannikko, Antti, Pietiäinen, Vilja, Grönholm, Mikaela, Cerullo, Vincenzo

“…Immunotherapy has emerged as a promising approach for cancer treatment, with oncolytic adenoviruses showing power as immunotherapeutic agents. In this study,…”
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Distinct molecular profiles and shared drug vulnerabilities in pancreatic metastases of renal cell carcinoma by Roos-Mattila, Matilda, Kallio, Pauliina, Luck, Tamara J., Polso, Minttu, Kumari, Romika, Mikkonen, Piia, Välimäki, Katja, Malmstedt, Minna, Ellonen, Pekka, Pellinen, Teijo, Heckman, Caroline A., Mustonen, Harri, Puolakkainen, Pauli A., Alitalo, Kari, Kallioniemi, Olli, Mirtti, Tuomas, Rannikko, Antti S., Pietiäinen, Vilja M., Seppänen, Hanna E.

“…Clear-cell renal cell carcinoma (ccRCC) is the most common origin of pancreatic metastases (PM). Distinct genomic aberrations, favorable prognosis, and…”
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ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer by Pellinen, Teijo, Blom, Sami, Sánchez, Sara, Välimäki, Katja, Mpindi, John-Patrick, Azegrouz, Hind, Strippoli, Raffaele, Nieto, Raquel, Vitón, Mariano, Palacios, Irene, Turkki, Riku, Wang, Yinhai, Sánchez-Alvarez, Miguel, Nordling, Stig, Bützow, Anna, Mirtti, Tuomas, Rannikko, Antti, Montoya, María C., Kallioniemi, Olli, del Pozo, Miguel A.

“…Caveolin-1 (CAV1) is over-expressed in prostate cancer (PCa) and is associated with adverse prognosis, but the molecular mechanisms linking CAV1 expression to…”
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Abstract 5490: Spatial profiling of inflamed tumor microenvironment of clear cell renal cell carcinoma by Pellinen, Teijo, Luomala, Lassi, Mattila, Kalle, Säilä, Jenni, Hemmes, Annabrita, Valimaki, Katja, Bruck, Oscar, Paavolainen, Lassi, Nisen, Harry, Järvinen, Petrus, Kallioniemi, Olli, Vainio, Paula, Jaakkola, Panu, Mirtti, Tuomas

“…Abstract Clear cell renal cell carcinoma (ccRCC) presents a distinctive tumor microenvironment (TME) characterized by extensive vascularization and immune…”
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Abstract 892: Pan-cancer tumor microenvironment profiling with multiplexed immunofluorescence microscopy and self-supervised learning by Atarsaikhan, Gantugs, Mogollon, Isabel, Välimäki, Katja, Mirtti, Tuomas, Pellinen, Teijo, Paavolainen, Lassi

“…Abstract Multiplexed immunofluorescence (mIF) microscopy reveals the spatial architecture of cancer tissue and its microenvironment that is not being fully…”
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Abstract 299: FAP/αSMA association with tumor visibility and progression in prostate cancer by Säilä, Jenni, Lehto, Timo-Pekka, Schoonenberg, Annabrita, Välimäki, Katja, Erickson, Andrew, Rannikko, Antti, Kallioniemi, Olli, Mirtti, Tuomas, Pellinen, Teijo

“…Abstract Introduction Prostate cancer (PCa) ranks as the second most frequently diagnosed cancer in the male population worldwide. The challenge in effectively…”
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Abstract 2945: Clinical implementation of precision systems oncology in the treatment of ovarian cancer based on ex-vivo drug testing and molecular profiling by Murumägi, Astrid, Ungureanu, Daniela, Khan, Suleiman, Hirasawa, Akira, Arjama, Mariliina, Välimäki, Katja, Mikkonen, Piia, Niininen, Wilhelmiina, Kumar, Ashwini, Eldfors, Samuli, Pellinen, Teijo, Pietiäinen, Vilja, Mägi, Andrus, Koivisto-Korander, Riitta, Tapper, Johanna, Loukovaara, Mikko, Aittokallio, Tero, Bützow, Ralf, Kallioniemi, Olli

“…Abstract Ovarian cancer (OC) is difficult to treat and has a high mortality rate. There is a strong need for new therapies, but OC is often not the main…”
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Quantitative Multiplex Immunohistochemistry Identifies Immunosuppression in the AML Bone Marrow and NK-Cells As Prognostic Biomarker in Intermediate-Risk Patients by Brück, Oscar, Dufva, Olli, Blom, Sami, Turkki, Riku, Ilander, Mette, Siitonen, Sanna M., Kovanen, Panu, Pallaud, Celine, Marques Ramos, Pedro, Lähteenmäki, Hanna, Välimäki, Katja, Ribeiro, Antonio, Kallioniemi, Olli, Porkka, Kimmo, Pellinen, Teijo, Mustjoki, Satu

“…BACKGROUND A complex interaction between blasts and surrounding cells in the acute myeloid leukemia (AML) bone marrow (BM) microenvironment sustains blast…”
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Abstract 4459: Spatial profiling of the inflamed tumor microenvironment identifies novel prognostic subclasses in non-metastatic clear cell renal carcinoma patients by Pellinen, Teijo, Luomala, Lassi, Mattila, Kalle, Säilä, Jenni, Hemmes, Annabrita, Välimäki, Katja, Bruck, Oscar, Paavolainen, Lassi, Nisen, Harry, Järvinen, Petrus, Kallioniemi, Olli, Vainio, Paula, Jaakkola, Panu, Mirtti, Tuomas

“…Abstract INTRODUCTION: Clear cell renal cell carcinoma (ccRCC) is highly vascularized and inflamed, and RNA signatures of angiogenesis/inflammation have been…”
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Abstract 2091: Open-source single-cell spatial image analysis pipeline for ten-plex immunofluorescence of histological prostate cancer tissue sections by Säilä, Jenni, Schoonenberg, Annabrita, Välimäki, Katja, Lehto, Timo-Pekka, Stürenberg, Carolin, Erickson, Andrew, Rannikko, Antti, Kallioniemi, Olli, Paavolainen, Lassi, Mirtti, Tuomas, Pellinen, Teijo

“…Abstract Introduction: Multiplexed fluorescence immunohistochemistry (mfIHC) allows the detection of multiple protein markers on the same histological tissue…”
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