Search Results - "Valiante, Nicholas M."

Nonviral delivery of self-amplifying RNA vaccines by Geall, Andrew J, Verma, Ayush, Otten, Gillis R, Shaw, Christine A, Hekele, Armin, Banerjee, Kaustuv, Cu, Yen, Beard, Clayton W, Brito, Luis A, Krucker, Thomas, O’Hagan, Derek T, Singh, Manmohan, Mason, Peter W, Valiante, Nicholas M, Dormitzer, Philip R, Barnett, Susan W, Rappuoli, Rino, Ulmer, Jeffrey B, Mandl, Christian W

“…Despite more than two decades of research and development on nucleic acid vaccines, there is still no commercial product for human use. Taking advantage of the…”
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A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines by Brito, Luis A, Chan, Michelle, Shaw, Christine A, Hekele, Armin, Carsillo, Thomas, Schaefer, Mary, Archer, Jacob, Seubert, Anja, Otten, Gillis R, Beard, Clayton W, Dey, Antu K, Lilja, Anders, Valiante, Nicholas M, Mason, Peter W, Mandl, Christian W, Barnett, Susan W, Dormitzer, Philip R, Ulmer, Jeffrey B, Singh, Manmohan, O'Hagan, Derek T, Geall, Andrew J

“…Nucleic acid-based vaccines such as viral vectors, plasmid DNA, and mRNA are being developed as a means to address a number of unmet medical needs that current…”
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Rational design of small molecules as vaccine adjuvants by Wu, Tom Y-H, Singh, Manmohan, Miller, Andrew T, De Gregorio, Ennio, Doro, Francesco, D'Oro, Ugo, Skibinski, David A G, Mbow, M Lamine, Bufali, Simone, Herman, Ann E, Cortez, Alex, Li, Yongkai, Nayak, Bishnu P, Tritto, Elaine, Filippi, Christophe M, Otten, Gillis R, Brito, Luis A, Monaci, Elisabetta, Li, Chun, Aprea, Susanna, Valentini, Sara, Calabrό, Samuele, Laera, Donatello, Brunelli, Brunella, Caproni, Elena, Malyala, Padma, Panchal, Rekha G, Warren, Travis K, Bavari, Sina, O'Hagan, Derek T, Cooke, Michael P, Valiante, Nicholas M

“…Adjuvants increase vaccine potency largely by activating innate immunity and promoting inflammation. Limiting the side effects of this inflammation is a major…”
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NKp46 and NKG2D Recognition of Infected Dendritic Cells Is Necessary for NK Cell Activation in the Human Response to Influenza Infection by Draghi, Monia, Pashine, Achal, Sanjanwala, Bharati, Gendzekhadze, Ketevan, Cantoni, Claudia, Cosman, David, Moretta, Alessandro, Valiante, Nicholas M, Parham, Peter

“…At an early phase of viral infection, contact and cooperation between dendritic cells (DCs) and NK cells activates innate immunity, and also influences…”
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Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells by Piccioli, Diego, Sbrana, Silverio, Melandri, Emiliano, Valiante, Nicholas M

“…Natural killer (NK) cells and dendritic cells (DCs) are two distinct cell types of innate immunity. It is known that the in vitro interaction of human NK cells…”
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Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection by Crotta, Stefania, Brazzoli, Michela, Piccioli, Diego, Valiante, Nicholas M, Wack, Andreas

“…Background & Aims Hepatitis C virus (HCV) is remarkably successful in establishing persistent infections due to its ability to evade host immune responses…”
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Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs by Francica, Joseph R., Zak, Daniel E., Linde, Caitlyn, Siena, Emilio, Johnson, Carrie, Juraska, Michal, Yates, Nicole L., Gunn, Bronwyn, De Gregorio, Ennio, Flynn, Barbara J., Valiante, Nicholas M., Malyala, Padma, Barnett, Susan W., Sarkar, Pampi, Singh, Manmohan, Jain, Siddhartha, Ackerman, Margaret, Alam, Munir, Ferrari, Guido, Salazar, Andres, Tomaras, Georgia D., O'Hagan, Derek T., Aderem, Alan, Alter, Galit, Seder, Robert A.

“…Adjuvants have a critical role for improving vaccine efficacy against many pathogens, including HIV. Here, using transcriptional RNA profiling and systems…”
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Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein by Crotta, Stefania, Stilla, Annalisa, Wack, Andreas, D'Andrea, Annalisa, Nuti, Sandra, D'Oro, Ugo, Mosca, Marta, Filliponi, Franco, Brunetto, R Maurizia, Bonino, Ferruccio, Abrignani, Sergio, Valiante, Nicholas M

“…The immune response against hepatitis C virus (HCV) is rarely effective at clearing the virus, resulting in approximately 170 million chronic HCV infections…”
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Human diversity in killer cell inhibitory receptor genes by Uhrberg, M, Valiante, N M, Shum, B P, Shilling, H G, Lienert-Weidenbach, K, Corliss, B, Tyan, D, Lanier, L L, Parham, P

“…The presence and expression of killer inhibitory receptor (KIR) and CD94:NKG2 genes from 68 donors were analyzed using molecular typing techniques. The genes…”
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Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells by Russo, Carla, Cornella-Taracido, Ivan, Galli-Stampino, Luisa, Jain, Rishi, Harrington, Edmund, Isome, Yuko, Tavarini, Simona, Sammicheli, Chiara, Nuti, Sandra, Mbow, M. Lamine, Valiante, Nicholas M., Tallarico, John, De Gregorio, Ennio, Soldaini, Elisabetta

“…TLR7 and TLR8 are intracellular sensors activated by single-stranded RNA species generated during viral infections. Various synthetic small molecules can also…”
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New adjuvants for human vaccines by Mbow, M Lamine, De Gregorio, Ennio, Valiante, Nicholas M, Rappuoli, Rino

“…Despite their obvious benefits, decades of research and hundreds of pre-clinical candidates, only a handful of adjuvants are approved for prophylactic…”
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Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors by Valiante, N M, Uhrberg, M, Shilling, H G, Lienert-Weidenbach, K, Arnett, K L, D'Andrea, A, Phillips, J H, Lanier, L L, Parham, P

“…The expression of KIR and CD94:NKG2 receptors was determined for more than 100 natural killer (NK) cell clones obtained from two blood donors who differ in…”
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mTOR inhibition improves immune function in the elderly by Mannick, Joan B, Del Giudice, Giuseppe, Lattanzi, Maria, Valiante, Nicholas M, Praestgaard, Jens, Huang, Baisong, Lonetto, Michael A, Maecker, Holden T, Kovarik, John, Carson, Simon, Glass, David J, Klickstein, Lloyd B

“…Inhibition of the mammalian target of rapamycin (mTOR) pathway extends life span in all species studied to date, and in mice delays the onset of age-related…”
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A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells by Santone, Melissa, Aprea, Susanna, Wu, Tom Y H, Cooke, Michael P, Mbow, M Lamine, Valiante, Nicholas M, Rush, James S, Dougan, Stephanie, Avalos, Ana, Ploegh, Hidde, De Gregorio, Ennio, Buonsanti, Cecilia, D'Oro, Ugo

“…Cross-presentation is the process by which professional APCs load peptides from an extracellularly derived protein onto class I MHC molecules to trigger a CD8…”
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Single-cell analysis of the human NK cell response to missing self and its inhibition by HLA class I by Draghi, Monia, Yawata, Nobuyo, Gleimer, Michael, Yawata, Makoto, Valiante, Nicholas M., Parham, Peter

“…Natural killer (NK) cells activate quickly in response to pathogens, tumors, and allogeneic hematopoietic cell transplants. Modulating the NK cell response are…”
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Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus by Bagnoli, Fabio, Fontana, Maria Rita, Soldaini, Elisabetta, Mishra, Ravi P N, Fiaschi, Luigi, Cartocci, Elena, Nardi-Dei, Vincenzo, Ruggiero, Paolo, Nosari, Sarah, De Falco, Maria Grazia, Lofano, Giuseppe, Marchi, Sara, Galletti, Bruno, Mariotti, Paolo, Bacconi, Marta, Torre, Antonina, Maccari, Silvia, Scarselli, Maria, Rinaudo, C Daniela, Inoshima, Naoko, Savino, Silvana, Mori, Elena, Rossi-Paccani, Silvia, Baudner, Barbara, Pallaoro, Michele, Swennen, Erwin, Petracca, Roberto, Brettoni, Cecilia, Liberatori, Sabrina, Norais, Nathalie, Monaci, Elisabetta, Bubeck Wardenburg, Juliane, Schneewind, Olaf, O'Hagan, Derek T, Valiante, Nicholas M, Bensi, Giuliano, Bertholet, Sylvie, De Gregorio, Ennio, Rappuoli, Rino, Grandi, Guido

“…Significance Staphylococcus aureus is a human pathogen causing life-threatening infections. The high incidence of methicillin-resistant S. aureus isolates…”
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Targeting the innate immune response with improved vaccine adjuvants by Pashine, Achal, Valiante, Nicholas M, Ulmer, Jeffrey B

“…Despite two centuries of vaccine use, only a few adjuvants and delivery systems are licensed for human use. This is partly because traditional vaccines based…”
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Recent advances in the discovery and delivery of vaccine adjuvants by O'Hagan, Derek T, Valiante, Nicholas M

“…Adjuvant design has historically had a touch of alchemy at its heart due to its reliance on the complex biology of innate immune activation. However, a new…”
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Novel adjuvant Alum-TLR7 significantly potentiates immune response to glycoconjugate vaccines by Buonsanti, Cecilia, Balocchi, Cristiana, Harfouche, Carole, Corrente, Federica, Galli Stampino, Luisa, Mancini, Francesca, Tontini, Marta, Malyala, Padma, Bufali, Simone, Baudner, Barbara, De Gregorio, Ennio, Valiante, Nicholas M., O’Hagan, Derek T., Rappuoli, Rino, D’Oro, Ugo

“…Although glycoconjugate vaccines are generally very efficacious, there is still a need to improve their efficacy, especially in eliciting a strong primary…”
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Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide by Cortez, Alex, Li, Yongkai, Miller, Andrew T, Zhang, Xiaoyue, Yue, Kathy, Maginnis, Jillian, Hampton, Janice, Hall, De Shon, Shapiro, Michael, Nayak, Bishnu, D’Oro, Ugo, Li, Chun, Skibinski, David, Mbow, M. Lamine, Singh, Manmohan, O’Hagan, Derek T, Cooke, Michael P, Valiante, Nicholas M, Wu, Tom Y.-H

“…Small molecule Toll-like receptor 7 (TLR7) agonists have been used as vaccine adjuvants by enhancing innate immune activation to afford better adaptive…”
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