Search Results - "Valiña, L."

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson's disease by Ge, Preston, Dawson, Valina L, Dawson, Ted M

“…That certain cell types in the central nervous system are more likely to undergo neurodegeneration in Parkinson's disease is a widely appreciated but poorly…”
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Microglia and astrocyte dysfunction in parkinson's disease by Kam, Tae-In, Hinkle, Jared T., Dawson, Ted M., Dawson, Valina L.

“…While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases,…”
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The cell biology of Parkinson's disease by Panicker, Nikhil, Ge, Preston, Dawson, Valina L, Dawson, Ted M

“…Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting from the death of dopamine neurons in the substantia nigra pars compacta. Our…”
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Parthanatos: mitochondrial‐linked mechanisms and therapeutic opportunities by Fatokun, Amos A, Dawson, Valina L, Dawson, Ted M

“…Cells die by a variety of mechanisms. Terminally differentiated cells such as neurones die in a variety of disorders, in part, via parthanatos, a process…”
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PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease by Shin, Joo-Ho, Ko, Han Seok, Kang, Hochul, Lee, Yunjong, Lee, Yun-Il, Pletinkova, Olga, Troconso, Juan C., Dawson, Valina L., Dawson, Ted M.

“…A hallmark of Parkinson's disease (PD) is the preferential loss of substantia nigra dopamine neurons. Here, we identify a new parkin interacting substrate,…”
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Genetic Animal Models of Parkinson's Disease by Dawson, Ted M., Ko, Han Seok, Dawson, Valina L.

“…Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized by the degeneration of dopamine (DA) and non-DA neurons, the almost…”
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The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration by Hinkle, Jared T., Dawson, Valina L., Dawson, Ted M.

“…We recently demonstrated that NLY01, a novel glucagon‐like peptide‐1 receptor agonist, exerts neuroprotective effects in two mouse models of PD in a…”
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Mitochondrial Mechanisms of Neuronal Cell Death: Potential Therapeutics by Dawson, Ted M, Dawson, Valina L

“…Mitochondria lie at the crossroads of neuronal survival and cell death. They play important roles in cellular bioenergetics, control intracellular Ca 2+…”
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The role of parkin in familial and sporadic Parkinson's disease by Dawson, Ted M., Dawson, Valina L.

“…Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and…”
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Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease by Kam, Tae-In, Mao, Xiaobo, Park, Hyejin, Chou, Shih-Ching, Karuppagounder, Senthilkumar S, Umanah, George Essien, Yun, Seung Pil, Brahmachari, Saurav, Panicker, Nikhil, Chen, Rong, Andrabi, Shaida A, Qi, Chen, Poirier, Guy G, Pletnikova, Olga, Troncoso, Juan C, Bekris, Lynn M, Leverenz, James B, Pantelyat, Alexander, Ko, Han Seok, Rosenthal, Liana S, Dawson, Ted M, Dawson, Valina L

“…The pathologic accumulation and aggregation of α-synuclein (α-syn) underlies Parkinson's disease (PD). The molecular mechanisms by which pathologic α-syn…”
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LRRK2 pathobiology in Parkinson's disease by Martin, Ian, Kim, Jungwoo Wren, Dawson, Valina L., Dawson, Ted M.

“…Mutations in the catalytic Roc‐COR and kinase domains of leucine‐rich repeat kinase 2 (LRRK2) are a common cause of familial Parkinson's disease (PD). LRRK2…”
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Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes by Scott, Laura, Dawson, Valina L., Dawson, Ted M.

“…Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the progressive loss of dopaminergic (DA) neurons. Most PD cases are…”
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MicroRNA-223 is neuroprotective by targeting glutamate receptors by Harraz, Maged M, Eacker, Stephen M, Wang, Xueqing, Dawson, Ted M, Dawson, Valina L

“…Stroke is a major cause of mortality and morbidity worldwide. Extracellular glutamate accumulation leading to overstimulation of the ionotropic glutamate…”
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The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease by Karuppagounder, Senthilkumar S., Brahmachari, Saurav, Lee, Yunjong, Dawson, Valina L., Dawson, Ted M., Ko, Han Seok

“…c-Abl is activated in the brain of Parkinson's disease (PD) patients and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice where it…”
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Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease by Martin, Ian, Kim, Jungwoo Wren, Lee, Byoung Dae, Kang, Ho Chul, Xu, Jin-Chong, Jia, Hao, Stankowski, Jeannette, Kim, Min-Sik, Zhong, Jun, Kumar, Manoj, Andrabi, Shaida A, Xiong, Yulan, Dickson, Dennis W, Wszolek, Zbigniew K, Pandey, Akhilesh, Dawson, Ted M, Dawson, Valina L

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and sporadic Parkinson's disease (PD). Elevated LRRK2 kinase activity and…”
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Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease by Kim, Sangjune, Kwon, Seung-Hwan, Kam, Tae-In, Panicker, Nikhil, Karuppagounder, Senthilkumar S., Lee, Saebom, Lee, Jun Hee, Kim, Wonjoong Richard, Kook, Minjee, Foss, Catherine A., Shen, Chentian, Lee, Hojae, Kulkarni, Subhash, Pasricha, Pankaj J., Lee, Gabsang, Pomper, Martin G., Dawson, Valina L., Dawson, Ted M., Ko, Han Seok

“…Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could spread from the gut to brain via the vagus nerve. Here, we test…”
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Parkin and PINK1: much more than mitophagy by Scarffe, Leslie A, Stevens, Daniel A, Dawson, Valina L, Dawson, Ted M

“…Highlights • Parkinson's disease is a mitochondrial disease of aging. • PINK1 and parkin are key players in multiple domains of mitochondrial health. • PINK1…”
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Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos by Wang, Yingfei, Dawson, Valina L., Dawson, Ted M.

“…Poly(ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in multiple neurologic diseases by mediating caspase-independent cell death, which has recently…”
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Parthanatos: Mechanisms, modulation, and therapeutic prospects in neurodegenerative disease and stroke by Yang, Liu, Guttman, Lauren, Dawson, Valina L., Dawson, Ted M.

“…[Display omitted] Parthanatos is a cell death signaling pathway that has emerged as a compelling target for pharmaceutical intervention. It plays a pivotal…”
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Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain by Kageyama, Yusuke, Hoshijima, Masahiko, Seo, Kinya, Bedja, Djahida, Sysa-Shah, Polina, Andrabi, Shaida A, Chen, Weiran, Höke, Ahmet, Dawson, Valina L, Dawson, Ted M, Gabrielson, Kathleen, Kass, David A, Iijima, Miho, Sesaki, Hiromi

“…Mitochondrial dynamics and mitophagy have been linked to cardiovascular and neurodegenerative diseases. Here, we demonstrate that the mitochondrial division…”
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