Search Results - "Valera, Isela"

Compensatory calcium handling may underlie increased arrhythmia susceptibility of sarcospan-deficient mice after ischemia-reperfusion injury by Rahimi Kahmini, Aida, Valera, Isela C., Cejas Carbonell, Alexis, Prascak, Julia, Mumbi, Florence, Parvatiyar, Michelle S., Hwang, Hyun S.

Get full text

Autoimmunity as a sequela to obesity and systemic inflammation by Kwiat, Victoria R, Reis, Gisienne, Valera, Isela C, Parvatiyar, Kislay, Parvatiyar, Michelle S

“…The rising prevalence of obesity presents a world-wide challenge as it is associated with numerous comorbidities including cardiovascular disease, insulin…”
Get full text

Sarcospan Deficiency Increases Oxidative Stress and Arrhythmias in Hearts after Acute Ischemia-Reperfusion Injury by Hwang, Hyun Seok, Kahmini, Aida Rahimi, Prascak, Julia, Cejas-Carbonell, Alexis, Valera, Isela C, Champion, Samantha, Corrigan, Mikayla, Mumbi, Florence, Parvatiyar, Michelle S

“…The protein sarcospan (SSPN) is an integral member of the dystrophin-glycoprotein complex (DGC) and has been shown to be important in the heart during the…”
Get full text

Aging reveals a sex-dependent susceptibility of sarcospan-deficient mice to cardiometabolic disease by Rahimi Kahmini, Aida, Valera, Isela C, Crawford, Rhiannon Q, Samarah, Luaye, Reis, Gisienne, Elsheikh, Salma, Kanashiro-Takeuchi, Rosemeire M, Mohammadipoor, Nazanin, Olateju, Bolade S, Matthews, Aaron R, Parvatiyar, Michelle S

“…Numerous genes including sarcospan (SSPN) have been designated as obesity-susceptibility genes by human genome-wide association studies. Variants in the locus…”
Get more information

Sarcospan‐deficient mice exhibit a heightened inflammatory phenotype under obesiogenic conditions by Crawford, Rhiannon Q., Valera, Isela C., Pindado, Jose, Reis, Gisienne, Kahmini, Aida R., Mumbi, Florence, Parvatiyar, Kislay, Parvatiyar, Michelle S.

“…To study the metabolic consequences of sarcospan (SSPN‐/‐) deletion we subjected WT and SSPN‐/‐ male mice to high fat diet (60% fat) for 4 months and compared…”
Get full text

Essential roles of the dystrophin-glycoprotein complex in different cardiac pathologies by Valera, Isela C., Wacker, Amanda L., Hwang, Hyun Seok, Holmes, Christina, Laitano, Orlando, Landstrom, Andrew P., Parvatiyar, Michelle S.

“…The dystrophin-glycoprotein complex (DGC), situated at the sarcolemma dynamically remodels during cardiac disease. This review examines DGC remodeling as a…”
Get full text

Cardiovascular Injury Due to SARS-CoV-2 by Bugert, Christina L., Kwiat, Victoria, Valera, Isela C., Bugert, Joachim J., Parvatiyar, Michelle S.

“…Purpose of Review The world is currently facing the largest global health crisis since the early 1900s due to a novel coronavirus . While SARS-CoV-2 infection…”
Get full text

Anti-vinculin antibodies in scleroderma (SSc): a potential link between autoimmunity and gastrointestinal system involvement in two SSc cohorts by Suliman, Yossra, Kafaja, Suzanne, Oh, Sunny J., Alemam, Mohamed, Bagnato, Gianluca, Abignano, Giuseppina, Singh, Ram Raj, Barlow, Gillian, Liu, Xiaochen, Valera, Isela, Morales, Walter, Rezaie, Ali, Pimentel, Mark, Del Galdo, Francesco, Furst, Daniel E

“…Background Systemic sclerosis (SSc) is an autoimmune disorder and commonly presents with vascular system involvement and motility disorders in the…”
Get full text

Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy by Marques, Mayra A, Landim-Vieira, Maicon, Moraes, Adolfo H, Sun, Bin, Johnston, Jamie R, Dieseldorff Jones, Karissa M, Cino, Elio A, Parvatiyar, Michelle S, Valera, Isela C, Silva, Jerson L, Galkin, Vitold E, Chase, P. Bryant, Kekenes-Huskey, Peter M, de Oliveira, Guilherme A. P, Pinto, Jose Renato

“…Cardiac TnC (cTnC) is highly conserved among mammals, and genetic variants can result in disease by perturbing Ca 2+ -regulation of myocardial contraction…”
Get full text

Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy by Dieseldorff Jones, Karissa M., Vied, Cynthia, Valera, Isela C., Chase, P. Bryant, Parvatiyar, Michelle S., Pinto, Jose R.

“…Heart disease remains the number one killer of women in the US. Nonetheless, studies in women and female animal models continue to be underrepresented in…”
Get full text

The impact of hindlimb disuse on sepsis‐induced myopathy in mice by Laitano, Orlando, Pindado, Jose, Valera, Isela, Spradlin, Ray A., Murray, Kevin O., Villani, Katelyn R., Alzahrani, Jamal M., Ryan, Terence E., Efron, Philip A., Ferreira, Leonardo F., Barton, Elisabeth R., Clanton, Thomas L.

“…Sepsis induces a myopathy characterized by loss of muscle mass and weakness. Septic patients undergo prolonged periods of limb muscle disuse due to bed rest…”
Get full text

Costimulation of Dectin-1 and DC-SIGN Triggers the Arachidonic Acid Cascade in Human Monocyte-Derived Dendritic Cells by Valera, Isela, Fernandez, Nieves, Trinidad, Antonio Garcia, Alonso, Sara, Brown, Gordon D, Alonso, Andres, Crespo, Mariano Sanchez

“…Inflammatory mediators derived from arachidonic acid (AA) alter the function of dendritic cells (DC), but data regarding their biosynthesis resulting from…”
Get full text

Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes by Alvarez, Yolanda, Valera, Isela, Municio, Cristina, Hugo, Etzel, Padrón, Francisco, Blanco, Lydia, Rodríguez, Mario, Fernández, Nieves, Crespo, Mariano Sánchez

“…The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic…”
Get full text

Mannose-Containing Molecular Patterns Are Strong Inducers of Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Human Macrophages by Fernandez, Nieves, Alonso, Sara, Valera, Isela, Vigo, Ana Gonzalez, Renedo, Marta, Barbolla, Luz, Crespo, Mariano Sanchez

“…The induction of cyclooxygenase-2 (COX-2) and the production of PGE(2) in response to pathogen-associated molecular patterns decorated with mannose moieties…”
Get full text

Peptidoglycan and mannose-based molecular patterns trigger the arachidonic acid cascade in human polymorphonuclear leukocytes by Valera, Isela, Vigo, Ana González, Alonso, Sara, Barbolla, Luz, Crespo, Mariano Sánchez, Fernández, Nieves

“…The release of arachidonic acid (AA) in response to microorganism‐derived products acting on pattern recognition receptors (PRR) was assayed in human…”
Get full text

Plasmacytoid dendritic cells contribute to pro-inflammatory and pro-fibrotic milieu in lung fibrosis by Singh, Ram Raj, Valera, Isela

“…Fibrosis, the end-result of tissue injury in a wide range of diseases, contributes to >40% of mortality in the US. Plasmacytoid dendritic cells (pDC) are…”
Get full text

Abstract 17706: Role of p62/SQSTM1 on Acute Ischemia-Induced Arrhythmias After Chronic Smoke in Mice by Hwang, Hyun Seok, Centner, Ann, Ukhanov, Vladimir, Zhao, Joanne, Cejas Carbonell, Alexis, Valera, Isela, Parvatiyar, Michelle, Salazar, Gloria

“…Abstract only Introduction: Cigarette smoke presents a high-risk factor for coronary heart disease development. Cigarette smoke is often linked with increased…”
Get full text

Abstract P3097: Sex-related Differences In Immune Responsiveness Of Sarcospan-deficient Mice To Metabolic Stress by Samarah, Luaye, Valera, Isela C, Reis, Gisienne, Rahimi Kahmini, Aida, Olateju, Bolade, Mohammadipour, Nazanin, Parvatiyar, Michelle S

“…Abstract only This study compares sex-related differences in inflammatory signaling that may contribute to metabolic and cardiovascular disease. The SSPN gene…”
Get full text

Establishing a Role for Sarcospan as an Obesity‐Susceptibility Gene in Mice by Matthews, Aaron, Valera, Isela, Crawford, Rhiannon, Elsheikh, Salma, Hwang, Hyun, Parvatiyar, Michelle

“…This study verifies genome‐wide association studies that connect variants in the SSPN locus, encoding the protein sarcospan, with increased waist circumference…”
Get full text

Reduction of P62/SQSTM1 on Calcium Handling in Stressed Myocytes by Hwang, Hyun Seok, Carbonell, Alexis, Rodriguez, Jose, Valera, Isela, Parvatiyar, Michelle, Salazar, Gloria

“…Introduction Cytosolic protein, p62/SQSTM1, regulates the protein turnover rate, and it interacts with various stress signaling proteins in cells…”
Get full text