Search Results - "Valentine, Ann M."

Cytotoxicity of a Ti(IV) compound is independent of serum proteins by Tinoco, Arthur D, Thomas, Horatio R, Incarvito, Christopher D, Saghatelian, Alan, Valentine, Ann M

“…Titanium(IV) compounds are excellent anticancer drug candidates, but they have yet to find success in clinical applications. A major limitation in developing…”
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Ti(IV) Binds to Human Serum Transferrin More Tightly Than Does Fe(III) by Tinoco, Arthur D, Valentine, Ann M

“…The binding of titanium(IV) to human serum transferrin in 50 mM Tris with 20 mM bicarbonate and 10 mM citrate at pH 7.4 was studied by UV/vis kinetics and by…”
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Bioinorganic Chemistry of Titanium by Buettner, Katherine M, Valentine, Ann M

“…A study examined the bioinorganic chemistry of titanium and its bioactivity. Titanium compounds possess a number of antibacterial, anti-inflammatory and…”
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REPLISOME-MEDIATED DNA REPLICATION by Benkovic, Stephen J, Valentine, Ann M, Salinas, Frank

“…The elaborate process of genomic replication requires a large collection of proteins properly assembled at a DNA replication fork. Several decades of research…”
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Contrasting Synergistic Anion Effects in Vanadium(V) Binding to Nicatransferrin versus Human Serum Transferrin by Gaffney, Jean P, Valentine, Ann M

“…Some ascidians sequester vanadium and other metal ions that are bound and transported in higher organisms by transferrin. The ascidian Ciona intestinalis has a…”
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Titanium(IV) Citrate Speciation and Structure under Environmentally and Biologically Relevant Conditions by Collins, Joseph M, Uppal, Ritika, Incarvito, Christopher D, Valentine, Ann M

“…The water-soluble complexes of Ti(IV) with citrate are of interest in environmental, biological, and materials chemistry. The aqueous solution speciation is…”
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Isolation and characterization of the iron-binding properties of a primitive monolobal transferrin from Ciona intestinalis by Uppal, Ritika, Lakshmi, K. V., Valentine, Ann M.

“…Transferrins are bilobal glycoproteins responsible for iron binding, transport, and delivery in many higher organisms. The two homologous lobes of transferrins…”
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On the evolutionary significance and metal-binding characteristics of a monolobal transferrin from Ciona intestinalis by Tinoco, Arthur D, Peterson, Cynthia W, Lucchese, Baldo, Doyle, Robert P, Valentine, Ann M

“…Transferrins are a family of proteins that bind and transport Fe(III). Modern transferrins are typically bilobal and are believed to have evolved from an…”
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Superstoichiometric Binding of the Anticancer Agent Titanocene Dichloride by Human Serum Transferrin and the Accompanying Lobe Closure by Profitt, Lauren A, Baxter, Richard H. G, Valentine, Ann M

“…Titanocene dichloride (TDC) is an anticancer agent that delivers Ti­(IV) into each of the two Fe­(III) binding sites of bilobal human serum transferrin (Tf)…”
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Titanium biomaterials: titania needles in the test of the foraminiferan Bathysiphon argenteus by Cole, Kathryn E, Valentine, Ann M

“…Scanning electron microscopy with energy dispersive microanalysis confirms the rare occurrence of a titanium mineral in the test of an organism…”
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Kinetic and spectroscopic characterization of intermediates and component interactions in reactions of methane monooxygenase from Methylococcus capsulatus (Bath) by Liu, Katherine E, Valentine, Ann M, Wang, Danli, Huynh, Boi Hanh, Edmondson, Dale E, Salifoglou, Anthanasios, Lippard, Stephen J

“…We describe mechanistic studies of the soluble methane monooxygenase (sMMO) enzyme system from Methylococcus capsulatus (Bath). Interactions among the three…”
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Contemplating a role for titanium in organisms by Zierden, Mark R, Valentine, Ann M

“…Titanium is the ninth most abundant element in the Earth's crust and some organisms sequester it avidly, though no essential biological role has yet been…”
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Ti(IV) and the Siderophore Desferrioxamine B: A Tight Complex Has Biological and Environmental Implications by Jones, Kayleigh E., Batchler, Kathleen L., Zalouk, Célia, Valentine, Ann M.

“…The siderophore desferrioxamine B (DFOB) binds Ti­(IV) tightly and precludes its hydrolytic precipitation under biologically and environmentally relevant…”
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Reconsideration of Serum Ti(IV) Transport:  Albumin and Transferrin Trafficking of Ti(IV) and Its Complexes by Tinoco, Arthur D, Eames, Emily V, Valentine, Ann M

“…The trafficking of titanium(IV) by human serum transferrin (HsTf) has been implicated in the physiology of this hydrolysis-prone metal. The current work…”
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Titanium(IV) and Vitamin C: Aqueous Complexes of a Bioactive Form of Ti(IV) by Buettner, Katherine M, Collins, Joseph M, Valentine, Ann M

“…Ascorbic acid is among the biorelevant ligands that render Ti(IV) stable in aqueous solution. A series of pH-dependent titanium(IV) coordination complexes of…”
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Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus by Liang, Hai, Zhou, Guangfeng, Ge, Yunhui, D'Ambrosio, Elizabeth A., Eidem, Tess M., Blanchard, Catlyn, Shehatou, Cindy, Chatare, Vijay K., Dunman, Paul M., Valentine, Ann M., Voelz, Vincent A., Grimes, Catherine L., Andrade, Rodrigo B.

“…[Display omitted] Antibiotic resistance is a serious threat to global public health, and methicillin-resistant Staphylococcus aureus (MRSA) is a poignant…”
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Solution structure, glycan specificity and of phenol oxidase inhibitory activity of Anopheles C-type lectins CTL4 and CTLMA2 by Bishnoi, Ritika, Sousa, Gregory L., Contet, Alicia, Day, Christopher J., Hou, Chun-Feng David, Profitt, Lauren A., Singla, Deepak, Jennings, Michael P., Valentine, Ann M., Povelones, Michael, Baxter, Richard H. G.

“…Malaria, the world’s most devastating parasitic disease, is transmitted between humans by mosquitoes of the Anopheles genus. An . gambiae is the principal…”
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Calorimetric, Spectroscopic, and Model Studies Provide Insight into the Transport of Ti(IV) by Human Serum Transferrin by Tinoco, Arthur D, Incarvito, Christopher D, Valentine, Ann M

“…Evidence suggests that transferrin can bind Ti(IV) in an unhydrolyzed form (without bound hydroxide or oxide) or in a hydrolyzed form. Ti(IV) coordination by…”
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A Zinc Ribbon Protein in DNA Replication:  Primer Synthesis and Macromolecular Interactions by the Bacteriophage T4 Primase by Valentine, Ann M, Ishmael, Faoud T, Shier, Vincent K, Benkovic, Stephen J

“…The gene product 61 primase protein from bacteriophage T4 was expressed as an intein fusion and purified to homogeneity. The primase binds one zinc ion, which…”
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Corona charge selective micelle degradation catalyzed by P. cepacia lipase isoforms by Zhu, Xiaobo, Fryd, Michael, Valentine, Ann M, Wayland, Bradford B

“…Micelles derived from poly(ε-caprolactone) (PCL) poly(ethylene glycol)(PEG) diblock copolymers (HO-PCLn-b-PEG32-RX, R = -O(CH2)3S(CH2)2-; X = -CO2(-), -SO3(-),…”
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