Search Results - "Valente, William J."

Mitochondrial DNA exhibits resistance to induced point and deletion mutations by Valente, William J, Ericson, Nolan G, Long, Alexandra S, White, Paul A, Marchetti, Francesco, Bielas, Jason H

“…The accumulation of somatic mitochondrial DNA (mtDNA) mutations contributes to the pathogenesis of human disease. Currently, mitochondrial mutations are…”
Get full text

Massively parallel digital transcriptional profiling of single cells by Zheng, Grace X. Y., Terry, Jessica M., Belgrader, Phillip, Ryvkin, Paul, Bent, Zachary W., Wilson, Ryan, Ziraldo, Solongo B., Wheeler, Tobias D., McDermott, Geoff P., Zhu, Junjie, Gregory, Mark T., Shuga, Joe, Montesclaros, Luz, Underwood, Jason G., Masquelier, Donald A., Nishimura, Stefanie Y., Schnall-Levin, Michael, Wyatt, Paul W., Hindson, Christopher M., Bharadwaj, Rajiv, Wong, Alexander, Ness, Kevin D., Beppu, Lan W., Deeg, H. Joachim, McFarland, Christopher, Loeb, Keith R., Valente, William J., Ericson, Nolan G., Stevens, Emily A., Radich, Jerald P., Mikkelsen, Tarjei S., Hindson, Benjamin J., Bielas, Jason H.

“…Characterizing the transcriptome of individual cells is fundamental to understanding complex biological systems. We describe a droplet-based system that…”
Get full text

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics by Rose, John C, Stephany, Jason J, Valente, William J, Trevillian, Bridget M, Dang, Ha V, Bielas, Jason H, Maly, Dustin J, Fowler, Douglas M

“…A rapidly inducible, autoinhibited SpCas9 and quantitative assessment of double-strand cleavage and indel formation allow insights into Cas9 kinetics in cell…”
Get full text

An In Vivo Model of Human Macrophages in Metastatic Melanoma by Voillet, Valentin, Berger, Trisha R, McKenna, Kelly M, Paulson, Kelly G, Tan, Wei Hong, Smythe, Kimberly S, Hunter, Daniel S, Valente, William J, Weaver, Stephanie, Campbell, Jean S, Kim, Teresa S, Byrd, David R, Bielas, Jason H, Pierce, Robert H, Chapuis, Aude G, Gottardo, Raphaël, Rongvaux, Anthony

“…Despite recent therapeutic progress, advanced melanoma remains lethal for many patients. The composition of the immune tumor microenvironment (TME) has…”
Get full text