Search Results - "Valešová, Lenka"
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Modeling sepsis, with a special focus on large animal models of porcine peritonitis and bacteremia
Published in Frontiers in physiology (10-01-2023)“…Infectious diseases, which often result in deadly sepsis or septic shock, represent a major global health problem. For understanding the pathophysiology of…”
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SOFA Score, Hemodynamics and Body Temperature Allow Early Discrimination between Porcine Peritonitis-Induced Sepsis and Peritonitis-Induced Septic Shock
Published in Journal of personalized medicine (28-02-2021)“…Porcine model of peritonitis-induced sepsis is a well-established clinically relevant model of human disease. Interindividual variability of the response often…”
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Lactate: The Fallacy of Oversimplification
Published in Biomedicines (01-12-2023)“…Almost a quarter of a millennium after the discovery of an acidic substance in sour milk by Swedish chemist Carl Wilhelm Scheele and more than 100 years after…”
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Molecular differences in susceptibility of the kidney to sepsis-induced kidney injury
Published in BMC nephrology (31-05-2017)“…Septic acute kidney injury affects 40-50% of all septic patients. Molecular differences between septic patients with and without acute kidney injury (AKI) are…”
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Mechanical Circulatory Support in Refractory Vasodilatory Septic Shock: a Randomized Controlled Porcine Study
Published in Shock (Augusta, Ga.) (01-01-2020)“…ABSTRACTAs controversy persists regarding the benefits of mechanical circulatory support in septic shock with a predominantly vasoplegic phenotype, preclinical…”
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Impact of sepsis on mitochondrial respiration of the porcine kidney
Published in Biochimica et biophysica acta. Bioenergetics (01-09-2018)Get full text
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Renal Proteomic Responses to Severe Sepsis and Surgical Trauma: Dynamic Analysis of Porcine Tissue Biopsies
Published in Shock (Augusta, Ga.) (01-10-2016)“…ABSTRACTAlthough the burden of septic acute kidney injury continues to increase, the molecular pathogenesis remains largely obscure. The aim of this…”
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Heart-rate variability depression in porcine peritonitis-induced sepsis without organ failure
Published in Experimental biology and medicine (Maywood, N.J.) (01-05-2017)“…Depression of heart-rate variability (HRV) in conditions of systemic inflammation has been shown in both patients and experimental animal models and HRV has…”
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Heart Rate Variability in Porcine Progressive Peritonitis-Induced Sepsis
Published in Frontiers in physiology (06-01-2016)“…Accumulating evidence suggests that heart rate variability (HRV) alterations could serve as an indicator of sepsis progression and outcome, however, the…”
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