Search Results - "Valeš, Karel"

Steroidomics in Men with Schizophrenia by Hill, Martin, Velíková, Marta, Hovorková, Tereza, Bulant, Josef, Janšáková, Katarína, Valeš, Karel

“…Schizophrenia is associated with numerous abnormalities, including imbalances in all hormonal axes, among which steroids play a major role. Steroidomic studies…”
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Inter-individual differences in laboratory rats as revealed by three behavioural tasks by Rudolfová, Veronika, Petrásek, Tomáš, Antošová, Eliška, Frynta, Daniel, Landová, Eva, Valeš, Karel, Nekovářová, Tereza

“…Stable inter-individual differences in behaviour and personality have been studied for several decades now. The aim of this study was to test the repeatability…”
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Metabolomics of Cerebrospinal Fluid Amino and Fatty Acids in Early Stages of Multiple Sclerosis by Židó, Michal, Kačer, David, Valeš, Karel, Zimová, Denisa, Štětkářová, Ivana

“…Multiple sclerosis (MS) is a demyelinating and neurodegenerative autoimmune disease of the central nervous system (CNS) damaging myelin and axons. Diagnosis is…”
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Metabolomics of Cerebrospinal Fluid in Multiple Sclerosis Compared With Healthy Controls: A Pilot Study by Židó, Michal, Kačer, David, Valeš, Karel, Svobodová, Zuzana, Zimová, Denisa, Štětkárová, Ivana

“…Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) leading to the loss of myelin and axons. Diagnosis is based on…”
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Revisiting monoamine oxidase inhibitors: A potential dual-action therapy for patients with prostate cancer and comorbid depression? by Vlcek, Premysl, Bob, Petr, Vales, Karel

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Psilocin and ketamine microdosing: effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats by Horsley, Rachel R, Páleníček, Tomáš, Kolin, Jan, Valeš, Karel

“…Short-term moderate doses of serotonergic and dissociative hallucinogens can be useful in the treatment of anxiety. Recently, a trend has developed for…”
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The Role of Zebrafish and Laboratory Rodents in Schizophrenia Research by Langova, Veronika, Vales, Karel, Horka, Petra, Horacek, Jiri

“…Schizophrenia is a severe disorder characterized by positive, negative and cognitive symptoms, which are still not fully understood. The development of…”
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Effect of human probiotics on memory, psychological and biological measures in elderly: A study protocol of bi-center, double-blind, randomized, placebo-controlled clinical trial (CleverAge Biota) by Bartos, Ales, Weinerova, Josefina, Diondet, Sofia, Vales, Karel

“…BackgroundGut microbiota may influence brain functions. Therefore, we prepared a study protocol for a double-blind, crossover, randomized clinical trial to…”
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Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease by Chalupova, Katarina, Korabecny, Jan, Bartolini, Manuela, Monti, Barbara, Lamba, Doriano, Caliandro, Rosanna, Pesaresi, Alessandro, Brazzolotto, Xavier, Gastellier, Anne-Julie, Nachon, Florian, Pejchal, Jaroslav, Jarosova, Michaela, Hepnarova, Vendula, Jun, Daniel, Hrabinova, Martina, Dolezal, Rafael, Zdarova Karasova, Jana, Mzik, Martin, Kristofikova, Zdena, Misik, Jan, Muckova, Lubica, Jost, Petr, Soukup, Ondrej, Benkova, Marketa, Setnicka, Vladimir, Habartova, Lucie, Chvojkova, Marketa, Kleteckova, Lenka, Vales, Karel, Mezeiova, Eva, Uliassi, Elisa, Valis, Martin, Nepovimova, Eugenie, Bolognesi, Maria Laura, Kuca, Kamil

“…A combination of tacrine and tryptophan led to the development of a new family of heterodimers as multi-target agents with potential to treat Alzheimer's…”
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Orexin supplementation in narcolepsy treatment: A review by Nepovimova, Eugenie, Janockova, Jana, Misik, Jan, Kubik, Stepan, Stuchlik, Ales, Vales, Karel, Korabecny, Jan, Mezeiova, Eva, Dolezal, Rafael, Soukup, Ondrej, Kobrlova, Tereza, Pham, Ngoc Lam, Nguyen, Thuy Duong, Konecny, Jan, Kuca, Kamil

“…Narcolepsy is a rare, chronic neurological disease characterized by excessive daytime sleepiness, cataplexy, vivid hallucinations, and sleep paralysis…”
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EFFECT OF CO-APPLICATION OF A NEUROSTEROID WITH HALOPERIDOL, RISPERIDONE, OR CLOZAPINE ON COGNITIVE AND POSITIVE SYMPTOMS IN THE MK-801 MODEL OF SCHIZOPHRENIA IN RATS by Svoboda, Jan, Krajcovic, Branislav, Janikova, Martina, Vales, Karel

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Open field test for the assessment of anxiety-like behavior in Gnathonemus petersii fish by Horka, Petra, Langova, Veronika, Hubeny, Jan, Vales, Karel, Chrtkova, Ivana, Horacek, Jiri

“…The open field test (OFT) is a basic and most widely used test for investigation in animal studies of the neurobiological basis of anxiety and screening for…”
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Pro-cognitive effects of dual tacrine derivatives acting as cholinesterase inhibitors and NMDA receptor antagonists by Chvojkova, Marketa, Kolar, David, Kovacova, Katarina, Cejkova, Lada, Misiachna, Anna, Hakenova, Kristina, Gorecki, Lukas, Horak, Martin, Korabecny, Jan, Soukup, Ondrej, Vales, Karel

“…Therapeutic options for Alzheimer’s disease are limited. Dual compounds targeting two pathways concurrently may enable enhanced effect. The study focuses on…”
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Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used? by Slamberova, Romana, Pometlova, Marie, Macuchova, Eva, Nohejlova, Kateryna, Stuchlik, Ales, Vales, Karel

“…•Prenatal methamphetamine exposure has complex effects on development of anxiety.•The effect of prenatal methamphetamine exposure on anxiety is modified by…”
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Use of psychedelics in the Czech Republic: results of recent population surveys by Chomynová, Pavla, Kočárová, Rita, Kňažek, Filip, Plevková, Michaela, Bláhová, Barbora, Valeš, Karel, Mravčík, Viktor

“…Objectives: Different psychoactive substances are widely used in today's society. So far limited data are available on the use of psychedelics in the general…”
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Frentizole derivatives with mTOR inhibiting and senomorphic properties by Chrienova, Zofia, Rysanek, David, Novak, Josef, Vasicova, Pavla, Oleksak, Patrik, Andrys, Rudolf, Skarka, Adam, Dumanovic, Jelena, Milovanovic, Zoran, Jacevic, Vesna, Chvojkova, Marketa, Holubova, Kristina, Vales, Karel, Skoupilova, Veronika, Valko, Marian, Jomova, Klaudia, Alomar, Suliman Y., Botelho, Fernanda D., Franca, Tanos C.C., Kuca, Kamil, Hodny, Zdenek, Nepovimova, Eugenie

“…Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) -…”
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Effects of Dizocilpine, Midazolam and Their Co-Application on the Trimethyltin (TMT)-Induced Rat Model of Cognitive Deficit by Chvojkova, Marketa, Kubova, Hana, Vales, Karel

“…Research of treatment options addressing the cognitive deficit associated with neurodegenerative disorders is of particular importance. Application of…”
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The Neuroactive Steroid Pregnanolone Glutamate: Anticonvulsant Effect, Metabolites and Its Effect on Neurosteroid Levels in Developing Rat Brains by Kudova, Eva, Mares, Pavel, Hill, Martin, Vondrakova, Katerina, Tsenov, Grygoriy, Chodounska, Hana, Kubova, Hana, Vales, Karel

“…Pregnanolone glutamate (PA-G) is a neuroactive steroid that has been previously demonstrated to be a potent neuroprotective compound in several biological…”
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Interactions of 17β-Hydroxysteroid Dehydrogenase Type 10 and Cyclophilin D in Alzheimer's Disease by Kristofikova, Zdenka, Springer, Tomas, Gedeonova, Erika, Hofmannova, Adéla, Ricny, Jan, Hromadkova, Lenka, Vyhnalek, Martin, Laczo, Jan, Nikolai, Tomas, Hort, Jakub, Petrasek, Tomas, Stuchlik, Ales, Vales, Karel, Klaschka, Jan, Homola, Jiri

“…The nucleus-encoded 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) regulates cyclophilin D (cypD) in the mitochondrial matrix. CypD regulates opening of…”
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The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity by Petrasek, Tomas, Vojtechova, Iveta, Lobellova, Veronika, Popelikova, Anna, Janikova, Martina, Brozka, Hana, Houdek, Pavel, Sladek, Martin, Sumova, Alena, Kristofikova, Zdenka, Vales, Karel, Stuchlík, Ales

“…The McGill-R-Thy1-APP transgenic rat is an animal model of the familial form of Alzheimer's disease (AD). This model mirrors several neuropathological…”
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