Search Results - "Vale, Wylie W."

The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress by Smith, Sean M., Vale, Wylie W.

“…Animals respond to stress by activating a wide array of behavioral and physiological responses that are collectively referred to as the stress response…”
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CRF and CRF receptors: Role in stress responsivity and other behaviors by BALER, Tracy L, VALE, Wylie W

“…Since corticotropin-releasing factor (CRF) was first characterized, a growing family of ligands and receptors has evolved. The mammalian family members include…”
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Structure of the Ternary Signaling Complex of a TGF-β Superfamily Member by Allendorph, George P., Vale, Wylie W., Choe, Senyon

“…The crystal structure of the complete signaling complex formed between bone morphogenetic protein 2 (BMP-2) and the extracellular domains (ECDs) of its type I…”
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Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells by van der Meulen, Talitha, Xie, Ruiyu, Kelly, Olivia G, Vale, Wylie W, Sander, Maike, Huising, Mark O

“…The peptide hormone Urocortin 3 (Ucn 3) is abundantly and exclusively expressed in mouse pancreatic beta cells where it regulates insulin secretion. Here we…”
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CRF type 2 receptors mediate the metabolic effects of ghrelin in C2C12 cells by Gershon, Eran, Vale, Wylie W.

“…Objective Ghrelin is known to regulate appetite control and cellular metabolism. The corticotropin‐releasing factor (CRF) family is also known to regulate…”
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triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery by Neufeld-Cohen, Adi, Tsoory, Michael M, Evans, Andrew K, Getselter, Dmitriy, Gil, Shosh, Lowry, Christopher A, Vale, Wylie W, Chen, Alon

“…Responding to stressful events requires numerous adaptive actions involving integrated changes in the central nervous and neuroendocrine systems. Numerous…”
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FoxL2 and Smad3 Coordinately Regulate Follistatin Gene Transcription by Blount, Amy L., Schmidt, Karsten, Justice, Nicholas J., Vale, Wylie W., Fischer, Wolfgang H., Bilezikjian, Louise M.

“…Follistatin is a transcriptional target and a modulator of activin action. Through an autocrine/paracrine loop, activin controls follistatin levels and thus…”
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Escitalopram alters gene expression and HPA axis reactivity in rats following chronic overexpression of corticotropin-releasing factor from the central amygdala by Flandreau, Elizabeth I, Bourke, Chase H, Ressler, Kerry J, Vale, Wylie W, Nemeroff, Charles B, Owens, Michael J

“…Summary We have previously demonstrated that viral-mediated overexpression of corticotropin-releasing factor (CRF) within the central nucleus of the amygdala…”
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Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand by Grace, Christy Rani R, Perrin, Marilyn H, Gulyas, Jozsef, DiGruccio, Michael R, Cantle, Jeffrey P, Rivier, Jean E, Vale, Wylie W, Riek, Roland

“…The corticotropin releasing factor (CRF) family of ligands and their receptors coordinate endocrine, behavioral, autonomic, and metabolic responses to stress…”
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International Union of Pharmacology. XXXVI. Current Status of the Nomenclature for Receptors for Corticotropin-Releasing Factor and Their Ligands by Hauger, Richard L, Grigoriadis, Dimitri E, Dallman, Mary F, Plotsky, Paul M, Vale, Wylie W, Dautzenberg, Frank M

“…Receptors for corticotropin-releasing factor (CRF) are members of a family of G protein-coupled receptors (“Family B”) that respond to a variety of…”
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CRFR1 is expressed on pancreatic β cells, promotes β cell proliferation, and potentiates insulin secretion in a glucose-dependent manner by Huising, Mark O, van der Meulen, Talitha, Vaughan, Joan M, Matsumoto, Masahito, Donaldson, Cynthia J, Park, Hannah, Billestrup, Nils, Vale, Wylie W

“…Corticotropin-releasing factor (CRF), originally characterized as the principal neuroregulator of the hypothalamus-pituitary-adrenal axis, has broad central…”
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Pituitary actions of ligands of the TGF-β family: activins and inhibins by Bilezikjian, Louise M, Blount, Amy L, Donaldson, Cindy J, Vale, Wylie W

“…Activins, as members of the transforming growth factor-β superfamily, control and orchestrate many physiological processes and are vital for the development,…”
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Antagonists of activin signaling: mechanisms and potential biological applications by Harrison, Craig A., Gray, Peter C., Vale, Wylie W., Robertson, David M.

“…Activins are members of the transforming growth factor-β (TGF-β) superfamily that control many physiological processes such as cell proliferation and…”
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Increased Depression-Like Behaviors in Corticotropin-Releasing Factor Receptor-2-Deficient Mice: Sexually Dichotomous Responses by Bale, Tracy L, Vale, Wylie W

“…Depressive disorders affect nearly 19 million American adults, making depression and the susceptibility for developing depression a critical focus of mental…”
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Expression and functional characterization of membrane-integrated mammalian corticotropin releasing factor receptors 1 and 2 in Escherichia coli by Jappelli, Roberto, Perrin, Marilyn H, Lewis, Kathy A, Vaughan, Joan M, Tzitzilonis, Christos, Rivier, Jean E, Vale, Wylie W, Riek, Roland

“…Corticotropin-Releasing Factor Receptors (CRFRs) are class B1 G-protein-coupled receptors, which bind peptides of the corticotropin releasing factor family and…”
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NMR Structure and Peptide Hormone Binding Site of the First Extracellular Domain of a Type B1 G Protein-Coupled Receptor by Christy R. R. Grace, Perrin, Marilyn H., DiGruccio, Michael R., Miller, Charleen L., Rivier, Jean E., Vale, Wylie W., Riek, Roland

“…The corticotropin-releasing factor (CRF) ligand family has diverse effects on the CNS, including the modulation of the stress response. The ligands' effects…”
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Control of Voltage-gated Potassium Channel Kv2.2 Expression by Pyruvate-Isocitrate Cycling Regulates Glucose-stimulated Insulin Secretion by Jensen, Mette V., Haldeman, Jonathan M., Zhang, Hengtao, Lu, Danhong, Huising, Mark O., Vale, Wylie W., Hohmeier, Hans E., Rosenberg, Paul, Newgard, Christopher B.

“…Recent studies have shown that the pyruvate-isocitrate cycling pathway, involving the mitochondrial citrate/isocitrate carrier and the cytosolic NADP-dependent…”
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Cripto Is a Noncompetitive Activin Antagonist That Forms Analogous Signaling Complexes with Activin and Nodal by Kelber, Jonathan A., Shani, Gidi, Booker, Evan C., Vale, Wylie W., Gray, Peter C.

“…Cripto plays critical roles during embryogenesis and has been implicated in promoting the growth and spread of tumors. Cripto is required for signaling by…”
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Mice Deficient for Both Corticotropin-Releasing Factor Receptor 1 (CRFR1) and CRFR2 Have an Impaired Stress Response and Display Sexually Dichotomous Anxiety-Like Behavior by Bale, Tracy L, Picetti, Roberto, Contarino, Angelo, Koob, George F, Vale, Wylie W, Lee, Kuo-Fen

“…Corticotropin-releasing factor (CRF) and its family of peptides are critical coordinators of homeostasis whose actions are mediated through their receptors,…”
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Chronic Activation of Corticotropin-Releasing Factor Type 2 Receptors Reveals a Key Role for 5-HT1A Receptor Responsiveness in Mediating Behavioral and Serotonergic Responses to Stressful Challenge by Neufeld-Cohen, Adi, Kelly, Paul A.T, Paul, Evan D, Carter, Roderick N, Skinner, Elizabeth, Olverman, Henry J, Vaughan, Joan M, Issler, Orna, Kuperman, Yael, Lowry, Christopher A, Vale, Wylie W, Seckl, Jonathan R, Chen, Alon, Jamieson, Pauline M

“…Background The corticotropin-releasing factor type 2 receptor (CRFR2) is suggested to play an important role in aiding recovery from acute stress, but any…”
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