Search Results - "Valdomir, Guillermo"

Chromanone Lactones: A Neglected Group of Natural Products – Isolation, Structure Elucidation, Bioactivity, and Synthesis by Valdomir, Guillermo, Tietze, Lutz F.

“…Chromanone lactones are a diverse family of fungal metabolites, which is biologically linked to tetrahydroxanthones. These compounds exhibit different…”
Get full text

Lambert–Eaton myasthenic syndrome: mouse passive‐transfer model illuminates disease pathology and facilitates testing therapeutic leads by Meriney, Stephen D., Tarr, Tyler B., Ojala, Kristine S., Wu, Man, Li, Yizhi, Lacomis, David, Garcia‐Ocaña, Adolfo, Liang, Mary, Valdomir, Guillermo, Wipf, Peter

“…Lambert–Eaton myasthenic syndrome (LEMS) is an autoimmune disorder caused by antibodies directed against the voltage‐gated calcium channels that provide the…”
Get full text

Broadening the Synthetic Scope of the Iron(III)-Catalyzed Aza-Prins Cyclization by Carballo, Rubén M., Valdomir, Guillermo, Purino, Martín, Martín, Víctor S., Padrón, Juan I.

“…The nature and influence of the N‐sulfonyl group in aza‐Prins cyclization and the reactivity of the six‐membered aza‐cycle generated has been studied. The…”
Get full text

(S)-(-)-Limonene Derivatives Containing (1H-1,2,3-Triazol-4-yl)methyl 4-Bromobenzoate by Valdomir, Guillermo, Davyt, Danilo

“…The synthesis of (S)-(-)-limonene derivatives containing (1H-1,2,3-triazol-4-yl)methyl 4-bromobenzoate were obtained by epoxidation, azidolysis and Huisgen’s…”
Get full text

Enantioselective Total Synthesis of the Fungal Metabolite Blennolide D and the Enantiomers of Blennolide E and F by Senthilkumar, Soundararasu, Valdomir, Guillermo, Ganapathy, Dhandapani, Zhang, Yun, Tietze, Lutz F

“…An enantioselective total synthesis of blennolide D and the enantiomers of blennolide E and F is described using an enantioselective Wacker-type oxidation…”
Get full text

Enantioselective Total Synthesis of Blennolide H and Phomopsis‐H76 A and Determination of Their Structure by Valdomir, Guillermo, Senthilkumar, Soundararasu, Ganapathy, Dhandapany, Zhang, Yun, Tietze, Lutz F.

“…This work reports on the enantioselective total synthesis of the two dimeric natural chromanone lactones phomopsis‐H76 A (5) and blennolide H (6). Both…”
Get full text

Enantioselective Total Synthesis and Structure Confirmation of the Natural Dimeric Tetrahydroxanthenone Dicerandrol C by Ganapathy, Dhandapani, Reiner, Johannes R., Valdomir, Guillermo, Senthilkumar, Soundararasu, Tietze, Lutz F.

“…The first enantioselective total synthesis of natural dicerandrol C (1 c) as its enantiomer containing a dimeric tetrahydroxanthenone skeleton is described…”
Get full text

Enantioselective Total Synthesis of Chromanone Lactone Homo‐ and Heterodimers by Valdomir, Guillermo, Senthilkumar, Soundararasu, Ganapathy, Dhandapany, Zhang, Yun, Tietze, Lutz F.

“…A one pot borylation/Suzuki–Miyaura reaction of the 4‐bromochromanone lactones 21 and 23, respectively, followed by cleavage of the methyl ether moieties gave…”
Get full text

Synthesis of Oxazole–Tetrahydropyran Hybrids and Study on Their Antiproliferative Activity Against Human Tumour Cells by Quintana, Vanesa, González‐Bakker, Aday, Padrón, Juan I., Martín, Víctor S., Padrón, José M., Davyt, Danilo, Valdomir, Guillermo

“…A series of triazole linked tetrahydropyran–oxazole hybrids was synthesized based on a previously reported lead compound with selective antiproliferative…”
Get full text

Enantioselective Total Synthesis and Structure Confirmation of the Natural Dimeric Tetrahydroxanthenone DicerandrolC by Ganapathy, Dhandapani, Reiner, Johannes R, Valdomir, Guillermo, Senthilkumar, Soundararasu, Tietze, Lutz F

“…The first enantioselective total synthesis of natural dicerandrolC (1c) as its enantiomer containing a dimeric tetrahydroxanthenone skeleton is described…”
Get full text

Novel tetrahydropyran‐triazole hybrids with antiproliferative activity against human tumor cells by Quintana, Vanesa, González‐Bakker, Aday, Khan, Adam N., Padrón, Juan I., Davyt, Danilo, Padrón, José M., Valdomir, Guillermo

“…A series of new hybrid compounds was prepared combining tetrahydropyran rings with different aromatic systems by means of a 1,2,3‐triazole, using a building…”
Get full text

Complete reversal of Lambert–Eaton myasthenic syndrome synaptic impairment by the combined use of a K+ channel blocker and a Ca2+ channel agonist by Tarr, Tyler B., Lacomis, David, Reddel, Stephen W., Liang, Mary, Valdomir, Guillermo, Frasso, Michael, Wipf, Peter, Meriney, Stephen D.

“…Key points Lambert–Eaton myasthenic syndrome (LEMS) is characterized by an autoimmune‐mediated attack on presynaptic P/Q‐type Ca2+ channels at the…”
Get full text

Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome by Tarr, Tyler B, Malick, Waqas, Liang, Mary, Valdomir, Guillermo, Frasso, Michael, Lacomis, David, Reddel, Stephen W, Garcia-Ocano, Adolfo, Wipf, Peter, Meriney, Stephen D

“…We developed a novel calcium (Ca(2+)) channel agonist that is selective for N- and P/Q-type Ca(2+) channels, which are the Ca(2+) channels that regulate…”
Get full text

New calcium channel agonists as potential therapeutics in Lambert-Eaton myasthenic syndrome and other neuromuscular diseases by Tarr, Tyler B., Valdomir, Guillermo, Liang, Mary, Wipf, Peter, Meriney, Stephen D.

“…Lambert–Eaton myasthenic syndrome (LEMS) causes neuromuscular weakness as a result of an autoimmune attack on the calcium channels that normally regulate…”
Get full text

Complete reversal of Lambert–Eaton myasthenic syndrome synaptic impairment by the combined use of a K + channel blocker and a Ca 2+ channel agonist by Tarr, Tyler B., Lacomis, David, Reddel, Stephen W., Liang, Mary, Valdomir, Guillermo, Frasso, Michael, Wipf, Peter, Meriney, Stephen D.

“…Key points Lambert–Eaton myasthenic syndrome (LEMS) is characterized by an autoimmune‐mediated attack on presynaptic P/Q‐type Ca 2+ channels at the…”
Get full text

Synthesis and Biological Evaluation of a Selective N- and P/Q-Type Calcium Channel Agonist by Liang, Mary, Tarr, Tyler B, Bravo-Altamirano, Karla, Valdomir, Guillermo, Rensch, Gabriel, Swanson, Lauren, DeStefino, Nicholas R, Mazzarisi, Cara M, Olszewski, Rachel A, Wilson, Gabriela Mustata, Meriney, Stephen D, Wipf, Peter

“…The acute effect of the potent cyclin-dependent kinase (cdk) inhibitor (R)-roscovitine on Ca2+ channels inspired the development of structural analogues as a…”
Get full text