Search Results - "Valdez, Laura B"

Complex I syndrome in striatum and frontal cortex in a rat model of Parkinson disease by Valdez, Laura B., Zaobornyj, Tamara, Bandez, Manuel J., López-Cepero, José María, Boveris, Alberto, Navarro, Ana

“…Mitochondrial dysfunction named complex I syndrome was observed in striatum mitochondria of rotenone treated rats (2 mg rotenone/kg, i. p., for 30 or 60 days)…”
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Mitochondrial metabolic states and membrane potential modulate mtNOS activity by Valdez, Laura B., Zaobornyj, Tamara, Boveris, Alberto

“…The mitochondrial metabolic state regulates the rate of NO release from coupled mitochondria: NO release by heart, liver and kidney mitochondria was about…”
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Mitochondrial nitric oxide synthase, a voltage-dependent enzyme, is responsible for nitric oxide diffusion to cytosol by Valdez, Laura B, Boveris, Alberto

“…The mitochondrial metabolic state regulates the rate of mitochondrial NO production and release to the cytosol. Nitric oxide release of rat heart mitochondria…”
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Nitric oxide metabolism in heart mitochondria by ZAOBORNYJ, Tamara, E. IGLESIAS, Dar韔, S. BOMBICINO, Silvina, BOVERIS, Alberto, B. VALDEZ, Laura

“…Normal cardiac function is accomplished through a continuous energy supply provided by mitochondria. Heart mitochondria are the major source of reactive oxygen…”
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Temporal evolution of cardiac mitochondrial dysfunction in a type 1 diabetes model. Mitochondrial complex I impairment, and H2O2 and NO productions as early subcellular events by Rukavina-Mikusic, Ivana A., Rey, Micaela, Martinefski, Manuela, Tripodi, Valeria, Valdez, Laura B.

“…The aim of this work was to study the early events that occur in heart mitochondria and to analyse the temporal evolution of cardiac mitochondrial dysfunction…”
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Superoxide and hydrogen peroxide productions by NO-inhibited complex III by E. IGLESIAS, Dar韔, S. BOMBICINO, Silvina, BOVERIS, Alberto, B. VALDEZ, Laura

“…Complex III plays a central role in the mitochondrial respiratory chain transferring electrons from ubiquinol to cytochrome c and pumping protons to the…”
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Role of matrix metalloproteinase-2 in the cardioprotective effect of ischaemic postconditioning by Donato, Martín, D’Annunzio, Verónica, Buchholz, Bruno, Miksztowicz, Verónica, Carrión, Cristina Lorenzo, Valdez, Laura B., Zaobornyj, Tamara, Schreier, Laura, Wikinski, Regina, Boveris, Alberto, Berg, Gabriela, Gelpi, Ricardo J.

“…The activation of matrix metalloproteinases (MMPs) contributes to myocardial injury at the onset of reperfusion; however, their role in ischaemic…”
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Mitochondrial H2O2 metabolism as central event of heart complex I syndrome in early diabetes by Rukavina-Mikusic, Ivana A., Rey, Micaela, Adán Areán, Juan S., Vanasco, Virginia, Alvarez, Silvia, Valdez, Laura B.

“…Hydrogen peroxide is the main metabolite effective in redox regulation and it is considered an insulinomimetic agent, with insulin signalling being essential…”
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Nitric oxide interacts with mitochondrial complex III producing antimycin-like effects by Iglesias, Darío E., Bombicino, Silvina S., Valdez, Laura B., Boveris, Alberto

“…The effect of NO between cytochromes b and c of the mitochondrial respiratory chain were studied using submitochondrial particles (SMP) from bovine heart and…”
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Hydrogen peroxide, nitric oxide and ATP are molecules involved in cardiac mitochondrial biogenesis in Diabetes by Bombicino, Silvina S., Iglesias, Darío E., Rukavina-Mikusic, Ivana A., Buchholz, Bruno, Gelpi, Ricardo J., Boveris, Alberto, Valdez, Laura B.

“…This study, in an experimental model of type I Diabetes Mellitus in rats, deals with the mitochondrial production rates and steady-state concentrations of H2O2…”
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Mitochondrial nitric oxide production supported by reverse electron transfer by Bombicino, Silvina S., Iglesias, Darío E., Zaobornyj, Tamara, Boveris, Alberto, Valdez, Laura B.

“…Heart phosphorylating electron transfer particles (ETPH) produced NO at 1.2 ± 0.1 nmol NO. min−1 mg protein−1 by the mtNOS catalyzed reaction. These particles…”
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Endotoxemia impairs heart mitochondrial function by decreasing electron transfer, ATP synthesis and ATP content without affecting membrane potential by Vanasco, Virginia, Magnani, Natalia D., Cimolai, María Cecilia, Valdez, Laura B., Evelson, Pablo, Boveris, Alberto, Alvarez, Silvia

“…Acute endotoxemia (LPS, 10 mg/kg ip, Sprague Dawley rats, 45 days old, 180 g) decreased the O 2 consumption of rat heart (1 mm 3 tissue cubes) by 33% (from…”
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(+)-Catechin inhibits heart mitochondrial complex I and nitric oxide synthase: functional consequences on membrane potential and hydrogen peroxide production by Iglesias, Darío E, Bombicino, Silvina S, Boveris, Alberto, Valdez, Laura B

“…In order to study the in vitro effect of flavan-3-ol (+)-catechin on the enzymatic activities of mitochondrial complex I and nitric oxide synthase (mtNOS), as…”
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Diabetes impairs heart mitochondrial function without changes in resting cardiac performance by Bombicino, Silvina S., Iglesias, Darío E., Mikusic, Ivana A. Rukavina, D’Annunzio, Verónica, Gelpi, Ricardo J., Boveris, Alberto, Valdez, Laura B.

“…Diabetes is a chronic disease associated to a cardiac contractile dysfunction that is not attributable to underlying coronary artery disease or hypertension,…”
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Mitochondrial metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol by Boveris, Alberto, Valdez, Laura B., Zaobornyj, Tamara, Bustamante, Juanita

“…Mitochondria isolated from rat heart, liver, kidney and brain (respiratory control 4.0–6.5) release NO and H 2O 2 at rates that depend on the mitochondrial…”
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Thioredoxin-1 Attenuates Ventricular and Mitochondrial Postischemic Dysfunction in the Stunned Myocardium of Transgenic Mice by Perez, Virginia, D'Annunzio, Veronica, Valdez, Laura B, Zaobornyj, Tamara, Bombicino, Silvina, Mazo, Tamara, Carbajosa, Nadia Longo, Gironacci, Mariela M, Boveris, Alberto, Sadoshima, Junichi, Gelpi, Ricardo J

“…We evaluated the effect of thioredoxin1 (Trx1) system on postischemic ventricular and mitochondrial dysfunction using transgenic mice overexpressing cardiac…”
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Heart mitochondrial nitric oxide synthase: a strategic enzyme in the regulation of cellular bioenergetics by Zaobornyj, Tamara, Valdez, Laura B

“…Heart mitochondria play a central role in cell energy provision and in signaling. Nitric oxide (NO) is a free radical which exerts an integral regulation of…”
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Complex I syndrome in myocardial stunning and the effect of adenosine by Valdez, Laura B., Zaobornyj, Tamara, Bombicino, Silvina, Iglesias, Darío E., Boveris, Alberto, Donato, Martin, D'Annunzio, Verónica, Buchholz, Bruno, Gelpi, Ricardo J.

“…Isolated rabbit hearts were exposed to ischemia (I; 15 min) and reperfusion (R; 5–30 min) in a model of stunned myocardium. I/R decreased left-ventricle O 2…”
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Polyphenols and red wine as antioxidants against peroxynitrite and other oxidants by Valdez, Laura B, Alvarez, Silvia, Zaobornyj, Tamara, Boveris, Alberto

“…The antioxidant capacity of polyphenols (+)-catechin, (-)-epicatechin and myricetin, and of different types of red wines (Cabernet Sauvignon, Malbec and…”
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Mitochondrial nitric oxide metabolism during rat heart adaptation to high altitude: effect of sildenafil, L-NAME, and L-arginine treatments by Zaobornyj, Tamara, Valdez, Laura B, Iglesias, Darío E, Gasco, Manuel, Gonzales, Gustavo F, Boveris, Alberto

“…Rats submitted to high altitude (Cerro de Pasco, Perú, 4,340 m, Po(2) = 12.2 kPa) for up to 84 days showed a physiological adaptive response with decreased…”
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