Search Results - "Valdez, Gregorio"

Argonaute 2 is lost from neuromuscular junctions affected with amyotrophic lateral sclerosis in SOD1G93A mice by Shapiro, Dillon, Massopust, Ryan, Taetzsch, Thomas, Valdez, Gregorio

“…miRNAs are necessary for neuromuscular junction (NMJ) health; however, little is known about the proteins required for their activity in this regard. We…”
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Specific labeling of synaptic schwann cells reveals unique cellular and molecular features by Castro, Ryan, Taetzsch, Thomas, Vaughan, Sydney K, Godbe, Kerilyn, Chappell, John, Settlage, Robert E, Valdez, Gregorio

“…Perisynaptic Schwann cells (PSCs) are specialized, non-myelinating, synaptic glia of the neuromuscular junction (NMJ), that participate in synapse development,…”
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MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice by Williams, Andrew H, Valdez, Gregorio, Moresi, Viviana, Qi, Xiaoxia, McAnally, John, Elliott, Jeffrey L, Bassel-Duby, Rhonda, Sanes, Joshua R, Olson, Eric N

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of motor neurons, denervation of target muscles, muscle atrophy, and…”
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Degeneration of proprioceptive sensory nerve endings in mice harboring amyotrophic lateral sclerosis-causing mutations by Vaughan, Sydney K., Kemp, Zachary, Hatzipetros, Theo, Vieira, Fernando, Valdez, Gregorio

“…ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily targets the motor system. Although much is known about the effects…”
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Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise by Valdez, Gregorio, Tapia, Juan C., Kang, Hyuno, Clemenson, Gregory D., Gage, F. H., Lichtman, Jeff W., Sanes, Joshua R., Fischbach, Gerald D.

“…The cellular basis of age-related behavioral decline remains obscure but alterations in synapses are likely candidates. Accordingly, the beneficial effects on…”
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Caloric Restriction Mimetics Slow Aging of Neuromuscular Synapses and Muscle Fibers by Stockinger, Jessica, Maxwell, Nicholas, Shapiro, Dillon, deCabo, Rafael, Valdez, Gregorio

“…Abstract Resveratrol and metformin have been shown to mimic some aspects of caloric restriction and exercise. However, it remains unknown if these molecules…”
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Shared resistance to aging and ALS in neuromuscular junctions of specific muscles by Valdez, Gregorio, Tapia, Juan C, Lichtman, Jeff W, Fox, Michael A, Sanes, Joshua R

“…Normal aging and neurodegenerative diseases both lead to structural and functional alterations in synapses. Comparison of synapses that are generally similar…”
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KLF15 overexpression in myocytes fails to ameliorate ALS-related pathology or extend the lifespan of SOD1G93A mice by Massopust, Ryan, Juros, Devin, Shapiro, Dillon, Lopes, Mikayla, Haldar, Saptarsi M., Taetzsch, Thomas, Valdez, Gregorio

“…Amyotrophic Lateral Sclerosis (ALS) is a currently incurable disease that causes progressive motor neuron loss, paralysis and death. Skeletal muscle pathology…”
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The ALS-inducing factors, TDP43A315T and SOD1G93A, directly affect and sensitize sensory neurons to stress by Vaughan, Sydney K., Sutherland, Natalia M., Zhang, Sihui, Hatzipetros, Theo, Vieira, Fernando, Valdez, Gregorio

“…There is increased recognition that sensory neurons located in dorsal root ganglia (DRG) are affected in amyotrophic lateral sclerosis (ALS). However, it…”
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The role of muscle microRNAs in repairing the neuromuscular junction by Valdez, Gregorio, Heyer, Mary P, Feng, Guoping, Sanes, Joshua R

“…microRNAs have been implicated in mediating key aspects of skeletal muscle development and responses to diseases and injury. Recently, we demonstrated that a…”
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Agrin and synaptic laminin are required to maintain adult neuromuscular junctions by Samuel, Melanie A, Valdez, Gregorio, Tapia, Juan C, Lichtman, Jeff W, Sanes, Joshua R

“…As synapses form and mature the synaptic partners produce organizing molecules that regulate each other's differentiation and ensure precise apposition of pre-…”
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Cellular and molecular alterations to muscles and neuromuscular synapses in a mouse model of MEGF10-related myopathy by Juros, Devin, Avila, Mary Flordelys, Hastings, Robert Louis, Pendragon, Ariane, Wilson, Liam, Kay, Jeremy, Valdez, Gregorio

“…Loss-of-function mutations in MEGF10 lead to a rare and understudied neuromuscular disorder known as MEGF10-related myopathy. There are no treatments for the…”
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Dynamic UTR Usage Regulates Alternative Translation to Modulate Gap Junction Formation during Stress and Aging by Zeitz, Michael J., Calhoun, Patrick J., James, Carissa C., Taetzsch, Thomas, George, Kijana K., Robel, Stefanie, Valdez, Gregorio, Smyth, James W.

“…Connexin43 (Cx43; gene name GJA1) is the most ubiquitously expressed gap junction protein, and understanding of its regulation largely falls under…”
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Attenuating Cholinergic Transmission Increases the Number of Satellite Cells and Preserves Muscle Mass in Old Age by Vaughan, Sydney K, Sutherland, Natalia M, Valdez, Gregorio

“…In addition to driving contraction of skeletal muscles, acetylcholine (ACh) acts as an anti-synaptogenic agent at neuromuscular junctions (NMJs). Previous…”
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Aging alters mechanisms underlying voluntary movements in spinal motor neurons of mice, primates, and humans by Castro, Ryan W, Lopes, Mikayla C, Settlage, Robert E, Valdez, Gregorio

“…Spinal motor neurons have been implicated in the loss of motor function that occurs with advancing age. However, the cellular and molecular mechanisms that…”
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Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging by Larouche, Jacqueline A, Mohiuddin, Mahir, Choi, Jeongmoon J, Ulintz, Peter J, Fraczek, Paula, Sabin, Kaitlyn, Pitchiaya, Sethuramasundaram, Kurpiers, Sarah J, Castor-Macias, Jesus, Liu, Wenxuan, Hastings, Robert Louis, Brown, Lemuel A, Markworth, James F, De Silva, Kanishka, Levi, Benjamin, Merajver, Sofia D, Valdez, Gregorio, Chakkalakal, Joe V, Jang, Young C, Brooks, Susan V, Aguilar, Carlos A

“…During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle volume and function impacting mobility and quality of life. Muscle loss…”
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Trk-signaling endosomes are generated by Rac-dependent macroendocytosis by Valdez, Gregorio, Philippidou, Polyxeni, Rosenbaum, Julie, Akmentin, Wendy, Shao, Yufang, Halegoua, Simon

“…Why neurotrophins and their Trk receptors promote neuronal differentiation and survival whereas receptor tyrosine kinases for other growth factors, such as…”
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Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction by Nishimune, Hiroshi, Valdez, Gregorio, Jarad, George, Moulson, Casey L, Müller, Ulrich, Miner, Jeffrey H, Sanes, Joshua R

“…A prominent feature of synaptic maturation at the neuromuscular junction (NMJ) is the topological transformation of the acetylcholine receptor (AChR)-rich…”
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Trk retrograde signaling requires persistent, Pincher-directed endosomes by Philippidou, Polyxeni, Valdez, Gregorio, Akmentin, Wendy, Bowers, William J., Federoff, Howard J., Halegoua, Simon, Mandel, Gail

“…Target-derived neurotrophins use retrogradely transported Trk-signaling endosomes to promote survival and neuronal phenotype at the soma. Despite their…”
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Podosomes are present in a postsynaptic apparatus and participate in its maturation by Proszynski, Tomasz J, Gingras, Jacinthe, Valdez, Gregorio, Krzewski, Konrad, Sanes, Joshua R

“…A critical step in synapse formation is the clustering of neurotransmitter receptors in the postsynaptic membrane, directly opposite the nerve terminal. At the…”
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