Search Results - "Valdes‐Mora, Fatima"

Genomic Cytometry and New Modalities for Deep Single‐Cell Interrogation by Salomon, Robert, Martelotto, Luciano, Valdes‐Mora, Fatima, Gallego‐Ortega, David

“…In the past few years, the rapid development of single‐cell analysis techniques has allowed for increasingly in‐depth analysis of DNA, RNA, protein, and…”
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Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer by Law, Andrew M K, Valdes-Mora, Fatima, Gallego-Ortega, David

“…The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and…”
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Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis by Papanicolaou, Michael, Parker, Amelia L., Yam, Michelle, Filipe, Elysse C., Wu, Sunny Z., Chitty, Jessica L., Wyllie, Kaitlin, Tran, Emmi, Mok, Ellie, Nadalini, Audrey, Skhinas, Joanna N., Lucas, Morghan C., Herrmann, David, Nobis, Max, Pereira, Brooke A., Law, Andrew M. K., Castillo, Lesley, Murphy, Kendelle J., Zaratzian, Anaiis, Hastings, Jordan F., Croucher, David R., Lim, Elgene, Oliver, Brian G., Mora, Fatima Valdes, Parker, Benjamin L., Gallego-Ortega, David, Swarbrick, Alexander, O’Toole, Sandra, Timpson, Paul, Cox, Thomas R.

“…The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial role in shaping their…”
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Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains by Khoury, Amanda, Achinger-Kawecka, Joanna, Bert, Saul A., Smith, Grady C., French, Hugh J., Luu, Phuc-Loi, Peters, Timothy J., Du, Qian, Parry, Aled J., Valdes-Mora, Fatima, Taberlay, Phillippa C., Stirzaker, Clare, Statham, Aaron L., Clark, Susan J.

“…The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is orchestrated to maintain long-range gene expression is…”
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Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer by Achinger-Kawecka, Joanna, Valdes-Mora, Fatima, Luu, Phuc-Loi, Giles, Katherine A., Caldon, C. Elizabeth, Qu, Wenjia, Nair, Shalima, Soto, Sebastian, Locke, Warwick J., Yeo-Teh, Nicole S., Gould, Cathryn M., Du, Qian, Smith, Grady C., Ramos, Irene R., Fernandez, Kristine F., Hoon, Dave S., Gee, Julia M. W., Stirzaker, Clare, Clark, Susan J.

“…Endocrine therapy resistance frequently develops in estrogen receptor positive (ER+) breast cancer, but the underlying molecular mechanisms are largely…”
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Disentangling single-cell omics representation with a power spectral density-based feature extraction by Zandavi, Seid Miad, Koch, Forrest C, Vijayan, Abhishek, Zanini, Fabio, Mora, Fatima Valdes, Ortega, David Gallego, Vafaee, Fatemeh

“…Abstract Emerging single-cell technologies provide high-resolution measurements of distinct cellular modalities opening new avenues for generating detailed…”
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Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies by Law, Andrew M K, Rodriguez de la Fuente, Laura, Grundy, Thomas J, Fang, Guocheng, Valdes-Mora, Fatima, Gallego-Ortega, David

“…Over 90% of potential anti-cancer drug candidates results in translational failures in clinical trials. The main reason for this failure can be attributed to…”
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Single-Cell Transcriptomics in Cancer Immunobiology: The Future of Precision Oncology by Valdes-Mora, Fatima, Handler, Kristina, Law, Andrew M K, Salomon, Robert, Oakes, Samantha R, Ormandy, Christopher J, Gallego-Ortega, David

“…Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a myriad of non-cancerous cell types that together with the extracellular…”
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Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes by Ajuyah, Pamela, Mayoh, Chelsea, Lau, Loretta M. S., Barahona, Paulette, Wong, Marie, Chambers, Hazel, Valdes-Mora, Fatima, Senapati, Akanksha, Gifford, Andrew J., D’Arcy, Colleen, Hansford, Jordan R., Manoharan, Neevika, Nicholls, Wayne, Williams, Molly M., Wood, Paul J., Cowley, Mark J., Tyrrell, Vanessa, Haber, Michelle, Ekert, Paul G., Ziegler, David S., Khuong-Quang, Dong-Anh

“…Diffuse midline gliomas (DMG) harbouring H3K27M mutation are paediatric tumours with a dismal outcome. Recently, a new subtype of midline gliomas has been…”
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Tumor dissociation of highly viable cell suspensions for single-cell omic analyses in mouse models of breast cancer by Rodriguez de la Fuente, Laura, Law, Andrew M.K., Gallego-Ortega, David, Valdes-Mora, Fatima

“…Cell preparation with a high rate of viable cells is required to obtain reliable single-cell transcriptomic and epigenomic data. This protocol describes a…”
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Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment by Gallego-Ortega, David, Ramirez de Molina, Ana, Ramos, Maria Angeles, Valdes-Mora, Fatima, Barderas, Maria Gonzalez, Sarmentero-Estrada, Jacinto, Lacal, Juan Carlos

“…The Kennedy pathway generates phosphocoline and phosphoethanolamine through its two branches. Choline Kinase (ChoK) is the first enzyme of the Kennedy branch…”
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Performance comparison of high throughput single-cell RNA-Seq platforms in complex tissues by Colino-Sanguino, Yolanda, Rodriguez de la Fuente, Laura, Gloss, Brian, Law, Andrew M.K., Handler, Kristina, Pajic, Marina, Salomon, Robert, Gallego-Ortega, David, Valdes-Mora, Fatima

“…Single-cell transcriptomics has emerged as the preferred tool to define cell identity through the analysis of gene expression signatures. However, there are…”
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Editorial: Epigenetic therapy against cancer: toward new molecular targets and technologies by Sousa, Ângela, Soares, Christiane P, Chin, Chung Man, Trisciuoglio, Daniela, Valdes-Mora, Fatima

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BCL-2 hypermethylation is a potential biomarker of sensitivity to antimitotic chemotherapy in endocrine-resistant breast cancer by Stone, Andrew, Cowley, Mark J, Valdes-Mora, Fatima, McCloy, Rachael A, Sergio, C Marcelo, Gallego-Ortega, David, Caldon, C Elizabeth, Ormandy, Christopher J, Biankin, Andrew V, Gee, Julia M W, Nicholson, Robert I, Print, Cristin G, Clark, Susan J, Musgrove, Elizabeth A

“…Overexpression of the antiapoptotic factor BCL-2 is a frequent feature of malignant disease and is commonly associated with poor prognosis and resistance to…”
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Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer by Stone, Andrew, Valdés-Mora, Fatima, Gee, Julia M W, Farrow, Lynne, McClelland, Richard A, Fiegl, Heidi, Dutkowski, Carol, McCloy, Rachael A, Sutherland, Robert L, Musgrove, Elizabeth A, Nicholson, Robert I

“…In the present study, we have taken the novel approach of using an in vitro model representative of tamoxifen-withdrawal subsequent to clinical relapse to…”
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Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer by Valdés-Mora, Fatima, Locke, Warwick J, Bandrés, Eva, Gallego-Ortega, David, Cejas, Paloma, García-Cabezas, Miguel Angel, Colino-Sanguino, Yolanda, Feliú, Jaime, Del Pulgar, Teresa Gómez, Lacal, Juan Carlos

“…CDC42 is an oncogenic Rho GTPase overexpressed in colorectal cancer (CRC). Although CDC42 has been shown to regulate gene transcription, the specific molecular…”
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ALTEN: A High‐Fidelity Primary Tissue‐Engineering Platform to Assess Cellular Responses Ex Vivo by Law, Andrew M. K., Chen, Jiamin, Colino‐Sanguino, Yolanda, Fuente, Laura Rodriguez de la, Fang, Guocheng, Grimes, Susan M., Lu, Hongxu, Huang, Robert J., Boyle, Sarah T., Venhuizen, Jeron, Castillo, Lesley, Tavakoli, Javad, Skhinas, Joanna N., Millar, Ewan K. A., Beretov, Julia, Rossello, Fernando J., Tipper, Joanne L., Ormandy, Christopher J., Samuel, Michael S., Cox, Thomas R., Martelotto, Luciano, Jin, Dayong, Valdes‐Mora, Fatima, Ji, Hanlee P., Gallego‐Ortega, David

“…To fully investigate cellular responses to stimuli and perturbations within tissues, it is essential to replicate the complex molecular interactions within the…”
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The H2A.Z-nuclesome code in mammals: emerging functions by Colino-Sanguino, Yolanda, Clark, Susan J, Valdes-Mora, Fatima

“…H2A.Z is a histone variant that provides specific structural and docking-side properties to the nucleosome, resulting in diverse and specialised molecular and…”
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The H2A.Z-nucleosome code in mammals: emerging functions by Colino-Sanguino, Yolanda, Clark, Susan J., Valdes-Mora, Fatima

“…H2A.Z is a histone variant that provides specific structural and docking-side properties to the nucleosome, resulting in diverse and specialised molecular and…”
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Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer by Valdés-Mora, Fátima, Gould, Cathryn M., Colino-Sanguino, Yolanda, Qu, Wenjia, Song, Jenny Z., Taylor, Kylie M., Buske, Fabian A., Statham, Aaron L., Nair, Shalima S., Armstrong, Nicola J., Kench, James G., Lee, Kenneth M. L., Horvath, Lisa G., Qiu, Minru, Ilinykh, Alexei, Yeo-Teh, Nicole S., Gallego-Ortega, David, Stirzaker, Clare, Clark, Susan J.

“…Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active promoters and is associated with oncogene activation in prostate cancer, but its role in…”
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