Search Results - "Valdes, Mario"

Contemporary Systemic Therapy Intensification for Prostate Cancer: A Review for General Practitioners in Oncology by Batra, Anupam, Glick, Daniel, Valdes, Mario

“…Prostate cancer accounts for a significant proportion of cancer diagnoses in Canadian men. Over the past decade, the therapeutic landscape for the management…”
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gmx_MMPBSA: A New Tool to Perform End-State Free Energy Calculations with GROMACS by Valdés-Tresanco, Mario S, Valdés-Tresanco, Mario E, Valiente, Pedro A, Moreno, Ernesto

“…Molecular mechanics/Poisson–Boltzmann (Generalized-Born) surface area is one of the most popular methods to estimate binding free energies. This method has…”
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Contemporary Management of Renal Cell Carcinoma: A Review for General Practitioners in Oncology by Tejura, Anish, Fernandes, Ricardo, Hubay, Stacey, Ernst, Matthew Scott, Valdes, Mario, Batra, Anupam

“…Renal cell carcinoma accounts for a significant proportion of cancer diagnoses in Canadians. Over the past several years, the management of renal cell cancers…”
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Biomarker Turnaround Times and Impact on Treatment Decisions in Patients with Advanced Non-Small Cell Lung Carcinoma at a Large Canadian Community Hospital with an Affiliated Regional Cancer Centre by Fleming, Katelyn E, Hupel, Ava, Mithoowani, Hamid, Lulic-Kuryllo, Tea, Valdes, Mario

“…: Timely reporting of molecular biomarkers is critical in guiding optimal treatment decisions in patients with advanced non-small cell lung carcinoma (NSCLC)…”
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Discovery of potent and selective inhibitors of the Escherichia coli M1-aminopeptidase via multicomponent solid-phase synthesis of tetrazole-peptidomimetics by Méndez, Yanira, De Armas, German, Pérez, Idalia, Rojas, Tamara, Valdés-Tresanco, Mario E., Izquierdo, Maikel, Alonso del Rivero, Maday, Álvarez-Ginarte, Yoanna María, Valiente, Pedro A., Soto, Carmen, de León, Lena, Vasco, Aldrin V., Scott, William L., Westermann, Bernhard, González-Bacerio, Jorge, Rivera, Daniel G.

“…The Escherichia coli neutral M1-aminopeptidase (ePepN) is a novel target identified for the development of antimicrobials. Here we describe a solid-phase…”
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Decoupling immunomodulatory properties from lipid binding in the α-pore-forming toxin Sticholysin II by Rivero-Hernández, Ada L., Hervis, Yadira P., Valdés-Tresanco, Mario E., Escalona-Rodríguez, Felipe A., Cancelliere, Rocco, Relova-Hernández, Ernesto, Romero-Hernández, Glenda, Pérez-Rivera, Eric, Torres-Palacios, Yusniel, Cartaya-Quintero, Patricia, Ros, Uris, Porchetta, Alessandro, Micheli, Laura, Fernández, Luis E., Laborde, Rady, Álvarez, Carlos, Sagan, Sandrine, Lanio, Maria Eliana, Pazos Santos, Isabel F.

“…Sticholysin II (StII), a pore-forming toxin from the marine anemone Stichodactyla helianthus, enhances an antigen-specific cytotoxic T lymphocyte (CTL)…”
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Discovery of tight-binding competitive inhibitors of dipeptidyl peptidase IV by Pascual Alonso, Isel, Valiente, Pedro A., Valdés-Tresanco, Mario E., Arrebola, Yarini, Almeida García, Fabiola, Díaz, Lisset, García, Gabriela, Guirola, Osmany, Pastor, Daniel, Bergado, Gretchen, Sánchez, Belinda, Charli, Jean-Louis

“…Dipeptidyl peptidase IV (DPP-IV, EC 3.4.14.5) is an abundant serine aminopeptidase that preferentially cleaves N-terminal Xaa-Pro or Xaa-Ala dipeptides from…”
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Growth differentiation factor 15 (GDF15) predicts relapse free and overall survival in unresected locally advanced non-small cell lung cancer treated with chemoradiotherapy by Di Pastena, Fiorella, Pond, Gregory, Tsakiridis, Evangelia E, Gouveia, Andre, Ahmadi, Elham, Biziotis, Olga-Demetra, Ali, Amr, Swaminath, Anand, Okawara, Gordon, Ellis, Peter M, Abdulkarim, Bassam, Ahmed, Naseer, Robinson, Andrew, Roa, Wilson, Valdes, Mario, Kavsak, Peter, Wierzbicki, Marcin, Wright, James, Steinberg, Gregory, Tsakiridis, Theodoros

“…Introduction Growth differentiation factor 15 (GDF15) is a cytokine of the TGF[beta] family. Here, we analyzed GDF15 levels in patients with locally advanced…”
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Efficacy of Rhipicephalus (Boophilus) microplus Bm86 against Hyalomma dromedarii and Amblyomma cajennense tick infestations in camels and cattle by Rodríguez-Valle, Manuel, Taoufik, Amar, Valdés, Mario, Montero, Carlos, Hassan, Ibrahim, Hassan, Shawgi Mohammed, Jongejan, Frans, de la Fuente, Jose

“…Highlights ► Vaccination trials with Bm86 based vaccine were conducted in cattle and camels. ► Bm86 protected against H. dromedarii in cattle and camels but to…”
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AMDock: a versatile graphical tool for assisting molecular docking with Autodock Vina and Autodock4 by Valdés-Tresanco, Mario S, Valdés-Tresanco, Mario E, Valiente, Pedro A, Moreno, Ernesto

“…AMDock (Assisted Molecular Docking) is a user-friendly graphical tool to assist in the docking of protein-ligand complexes using Autodock Vina and AutoDock4,…”
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Hexahydropyrrolo[2,3‑b]indole Compounds as Potential Therapeutics for Alzheimer’s Disease by Doens, Deborah, Valdés-Tresanco, Mario E, Vasquez, Velmarini, Carreira, Maria Beatriz, De La Guardia, Yila, Stephens, David E, Nguyen, Viet D, Nguyen, Vu T, Gu, Jianhua, Hegde, Muralidhar L, Larionov, Oleg V, Valiente, Pedro A, Lleonart, Ricardo, Fernández, Patricia L

“…Alzheimer’s disease (AD) is the most common form of dementia among the elderly and has become a leading public health concern worldwide. It represents a huge…”
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Systemic Therapy Outcomes in Adult Patients with Ewing Sarcoma Family of Tumors by Valdes, Mario, Nicholas, Garth, Verma, Shailendra, Asmis, Timothy

“…Background: The Ewing sarcoma family of tumors (ESFT) is a rare but curable bone neoplastic entity. The current standard of care involves chemotherapy and…”
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Assessment of Different Parameters on the Accuracy of Computational Alanine Scanning of Protein–Protein Complexes with the Molecular Mechanics/Generalized Born Surface Area Method by Valdés-Tresanco, Mario E., Valdés-Tresanco, Mario S., Moreno, Ernesto, Valiente, Pedro A.

“…Computational alanine scanning with the molecular mechanics generalized Born surface area (MM/GBSA) method constitutes a widely used approach for identifying…”
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Eastern Canadian Gastrointestinal Cancer Consensus Conference 2019 by Gotfrit, Joanna, Goodwin, Rachel, Asmis, Timothy, Hyde, Angela J., Alcindor, Thierry, Aubin, Francine, Berry, Scott, Bossé, Dominick, Brown, Colin, Burkes, Ronald, Burnell, Margot, Colwell, Bruce, Corbett, Jessica, Craswell, Jeff, Daaboul, Nathalie, Doherty, Mark, Fleming, D. A. Barry, Galvis, Luisa, Goel, Rakesh, Harb, Mohammed, Jeyakumar, Alwin, Jonker, Derek, Kennedy, Erin, Lock, Michael, Mahmud, Aamer, McCrea, Patrick H., Nair, Vimoj, Nassabein, Rami, Nessim, Carolyn, Ramjeesingh, Ravi, Raza, Muhammad, Saliba, Wissam, Samimi, Satareh, Singh, Simron, Snow, Stephanie, Tehfé, Mustapha, Thirlwell, Michael, Valdes, Mario, Welch, Stephen, Vickers, Michael

“…The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2019 was held in Morell, Prince Edward Island, 19–21 September 2019. Experts in…”
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Structural Modeling of Nanobodies: A Benchmark of State-of-the-Art Artificial Intelligence Programs by Valdés-Tresanco, Mario S, Valdés-Tresanco, Mario E, Jiménez-Gutiérrez, Daiver E, Moreno, Ernesto

“…The number of applications for nanobodies is steadily expanding, positioning these molecules as fast-growing biologic products in the biotechnology market…”
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Structural Insights into the Design of Synthetic Nanobody Libraries by Valdés-Tresanco, Mario S, Molina-Zapata, Andrea, Pose, Alaín González, Moreno, Ernesto

“…Single domain antibodies from camelids, or nanobodies, are a unique class of antibody fragments with several advantageous characteristics: small monomeric…”
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Tailored Parameterization of the LIE Method for Calculating the Binding Free Energy of Vps34–Inhibitor Complexes by Valdés-Tresanco, Mario S, Valdés-Tresanco, Mario E, Rubio-Carrasquilla, Marcela, Valiente, Pedro A, Moreno, Ernesto

“…Vps34 is the only isoform of the PI3K family in fungi, making this protein an attractive target to develop new treatments against pathogenic fungi. The high…”
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NbThermo: a new thermostability database for nanobodies by Valdés-Tresanco, Mario S, Valdés-Tresanco, Mario E, Molina-Abad, Esteban, Moreno, Ernesto

“…Abstract We present NbThermo—a first-in-class database that collects melting temperatures (Tm), amino acid sequences and several other categories of useful…”
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Protein surface roughness accounts for binding free energy of Plasmepsin II‐ligand complexes by Valdés‐Tresanco, Mario E., Valdés‐Tresanco, Mario S., Valiente, Pedro A., Cocho, Germinal, Mansilla, Ricardo, Nieto‐Villar, J.M.

“…The calculation of absolute binding affinities for protein‐inhibitor complexes remains as one of the main challenges in computational structure‐based ligand…”
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A program to automate the discovery of drugs for West Nile and Dengue virus-programmatic screening of over a billion compounds on PubChem, generation of drug leads and automated in silico modelling by Geoffrey, Ben, Sanker, Akhil, Madaj, Rafal, Tresanco, Mario Sergio Valdés, Upadhyay, Manish, Gracia, Judith

“…Our work is composed of a python program for programmatic data mining of PubChem to collect data to implement a machine learning-based AutoQSAR algorithm to…”
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