Search Results - "Valasinas, A"

Novel Synthetic Polyamines Are Effective in the Treatment of Experimental Microsporidiosis, an Opportunistic AIDS-Associated Infection by BACCHI, Cyrus J, WEISS, Louis M, YARLETT, Nigel, WITTNER, Murray, LANE, Schenella, FRYDMAN, Benjamin, VALASINAS, Aldonia, REDDY, Venodhar, SUN, Jerry S, MARTON, Laurence J, KHAN, Imitiaz A, MORETTO, Magali

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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[1N,12N]Bis(Ethyl)-cis-6,7-Dehydrospermine: a New Drug for Treatment and Prevention of Cryptosporidium parvum Infection of Mice Deficient in T-Cell Receptor Alpha by Waters, W.R, Frydman, B, Marton, L.J, Valasinas, A, Reddy, V.K, Harp, J.A, Wannemuehler, M.J, Yarlett, N

“…Cryptosporidium parvum infection of T-cell receptor alpha (TCR-α)-deficient mice results in a persistent infection. In this study, treatment with a polyamine…”
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Spectroscopic evidence for a porphobilinogen deaminase-tetrapyrrole complex that is an intermediate in the biosynthesis of uroporphyrinogen III by Rose, Sergio, Frydman, Rosalia B, de los Santos, Carlos, Sburlati, Adriana, Valasinas, Aldonia, Frydman, Benjamin

“…Incubation of porphobilinogen (PBG) with PBG deaminase from Rhodopseudomonas sphaeroides in carbonate buffer (pH 9.2) to total PBG consumption resulted in low…”
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Long-chain polyamines (oligoamines) exhibit strong cytotoxicities against human prostate cancer cells by Valasinas, Aldonia, Reddy, Venodhar K, Blokhin, Andrei V, Basu, Hirak S, Bhattacharya, Subhra, Sarkar, Aparajita, Marton, Laurence J, Frydman, Benjamin

“…α N, ω N-bis(ethyl) octamine SL-11160, decamine SL-11159, dodecamine SL-11226, and tetradecamine SL-11175 were chemically synthesized. We called this class of…”
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Suppression and Regression of Choroidal Neovascularization by Polyamine Analogues by Silva, Raquel Lima e, Saishin, Yoshitsugu, Saishin, Yumiko, Akiyama, Hideo, Kachi, Shu, Aslam, Sadia, Rogers, Brian, Deering, Tye, Gong, Yuan Yuan, Hackett, Sean F, Lai, Hong, Frydman, Benjamin J, Valasinas, Aldonia, Marton, Laurence J, Campochiaro, Peter A

“…Polyamine analogues inhibit tumor growth in vitro and in vivo, and oligoamines with a chain length of 10, 12, or 14 are particularly potent. This study was…”
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Cyclopropane-Containing Polyamine Analogues Are Efficient Growth Inhibitors of a Human Prostate Tumor Xenograft in Nude Mice by Frydman, Benjamin, Blokhin, Andrei V, Brummel, Sara, Wilding, George, Maxuitenko, Yulia, Sarkar, Aparajita, Bhattacharya, Subhra, Church, Dawn, Reddy, Venodhar K, Kink, John A, Marton, Laurence J, Valasinas, Aldonia, Basu, Hirak S

“…Polyamine analogues 7, 10, 18, 27, and 32 containing cyclopropane rings were obtained by chemical synthesis. Their antineoplastic activities were assessed…”
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A novel polyamine analog (SL-11093) inhibits growth of human prostate tumor xenografts in nude mice by Frydman, Benjamin, Porter, Carl W, Maxuitenko, Yulia, Sarkar, Aparajita, Bhattacharya, Subhra, Valasinas, Aldonia, Reddy, Venodhar K, Kisiel, Nick, Marton, Laurence J, Basu, Hirak S

“…We tested the polyamine analog SL-11093 (3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane tetrahydrochloride) as an effective chemotherapeutic agent…”
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Cis-Unsaturated Analogues of 3,8,13,18,23-Pentaazapentacosane (BE-4-4-4-4):  Synthesis and Growth Inhibitory Effects on Human Prostate Cancer Cell Lines by Reddy, Venodhar K, Sarkar, Aparajita, Valasinas, Aldonia, Marton, Laurence J, Basu, Hirak S, Frydman, Benjamin

“…From the results of our previous physicochemical studies of polyamine−nucleic acid interactions, we concluded that polyamine analogues in cisoidal conformation…”
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Biosynthesis of Uroporphyrinogens from Porphobilinogen: Mechanism and the Nature of the Process by Frydman, B., Frydman, Rosalia B., Valasinas, Aldonia, Levy, Estrella S., Feinstein, Graciela

“…The enzymic self-polymerization of porphobilinogen gives rise to the cyclic tetrapyrroles uroporphyrinogen III and uroporphyrinogen I. The former is the…”
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Mechanism of uroporphyrinogen biosynthesis from porphobilinogen by Frydman, R B, Valasinas, A, Frydman, B

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Concerning the Synthesis of 3,7,13,17-Tetramethyl-5,15-diphenylporphyrin, a Sterically Hindered Porphyrin by Valasinas, Aldonia, Hurst, Jorge, Frydman, Benjamin

“…The synthesis of the sterically hindered porphyrin 1 (3,7,13,17-tetramethyl-5,15-diphenylporphyrin) could only be achieved by first preparing a 5,15-meso…”
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Conformationally restricted analogues of 1N, 14N-bisethylhomospermine (BE-4-4-4) : Synthesis and growth inhibitory effects on human prostate cancer cells by VALASINAS, Aldonia, SARKAR, Aparajita, REDDY, Venodhar K, MARTON, Laurence J, BASU, Hirak S, FRYDMAN, Benjamin

“…Twelve analogues of 1N,14N-bisethylhomospermine (BE-4-4-4) with restricted conformations were synthesized in the search for cancer chemotherapeutic agents with…”
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SL-11158, a synthetic oligoamine, inhibits polyamine metabolism of Encephalitozoon cuniculi by Bacchi, C J, Orozco, D, Weiss, L M, Frydman, B, Valasinas, A, Yarlett, N, Marton, L J, Wittner, M

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Synthesis of a decahydrohexapyrrin: A novel oligopyrrole of biosynthetic interest by Kogan, Marcelo, Valasinas, Aldonia, Frydman, Benjamin

“…A decahydrohexapyrrin substituted with 12 acetic and propionic acid residues was prepared using a (2+2+2) type synthesis. The hexapyrrin mimics the unique…”
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Conformationally restricted analogues of 1N, 12N-bisethylspermine : Synthesis and growth inhibitory effects on human tumor cell lines by REDDY, V. K, VALASINAS, A, SARKAR, A, BASU, H. S, MARTON, L. J, FRYDMAN, B

“…Eight analogues of 1N,12N-bisethylspermine (BES) with restricted conformations were synthesized in the search for new spermine mimetics with cytotoxic…”
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A Novel Polyamine Analog Inhibits Growth and Induces Apoptosis in Human Breast Cancer Cells by YI HUANG, HAGER, Erin R, CASERO, Robert A, DAVIDSON, Nancy E, PHILLIPS, Dawn L, DUNN, Valerie R, HACKER, Amy, FRYDMAN, Benjamin, KINK, John A, VALASINAS, Aldonia L, REDDY, Venodhar K, MARTON, Laurence J

“…Polyamine analogs have demonstrated considerable activity against many important solid tumor models including breast cancer. However, the precise mechanisms of…”
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Antizyme induction by polyamine analogues as a factor of cell growth inhibition by Mitchell, John L A, Leyser, Aviva, Holtorff, Michelle S, Bates, Jill S, Frydman, Benjamin, Valasinas, Aldonia L, Reddy, Venodhar K, Marton, Laurence J

“…The polyamines spermidine and spermine and their diamine precursor putrescine are essential for mammalian cell growth and viability, and strategies are sought…”
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SL-11158, a Synthetic Oligoamine, Inhibits Polyamine Metabolism of Encephalitozoon cuniculi by BACCHl, CYRUS J., OROZCO, DANIEL, WEISS, LOUIS M., FRYDMAN, BENJAMIN, VALASINAS, ALDONIA, YARLETT, NIGEL, MARTON, LAURENCE J., WITTNER, MURRAY

“…Polyamine metabolism as a target for drug intervention in rapidly proliferating cells has evolved within the past two decades. The initial impetus was to block…”
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Synthesis of (R)- and (S)-4,5-diaminovaleric acids by Valasinas, Aldonia, Frydman, Benjamin, Friedmann, Herbert C

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Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells by Devereux, Wendy, Wang, Yanlin, Stewart, Tracy Murray, Hacker, Amy, Smith, Renee, Frydman, Benjamin, Valasinas, Aldonia L, Reddy, Venodhar K, Marton, Laurence J, Ward, Tracey D, Woster, Patrick M, Casero, Robert A

“…The induction of polyamine catabolism has been directly associated with the cytotoxic response of various tumor types to the antitumor polyamine analogues…”
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