Search Results - "Valanciute, Asta"

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells by Din, Farhat V.N, Valanciute, Asta, Houde, Vanessa P, Zibrova, Daria, Green, Kevin A, Sakamoto, Kei, Alessi, Dario R, Dunlop, Malcolm G

“…Background & Aims Aspirin reduces the incidence of and mortality from colorectal cancer (CRC) by unknown mechanisms. Cancer cells have defects in signaling via…”
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A novel approach to investigation of the pathogenesis of active minimal-change nephrotic syndrome using subtracted cDNA library screening by SAHALI, Djillali, PAWLAK, André, VALANCIUTE, Asta, GRIMBERT, Philippe, LANG, Philippe, REMY, Philippe, BENSMAN, Albert, GUELLAËN, Georges

“…Clinical and experimental observations suggest that minimal-change nephrotic syndrome (MCNS) results from T cell dysfunction, via unknown mechanisms. For the…”
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Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization by Grimbert, Philippe, Valanciute, Asta, Audard, Vincent, Pawlak, André, Le gouvelo, Sabine, Lang, Philippe, Niaudet, Patrick, Bensman, Albert, Guellaën, Georges, Sahali, Djillali

“…Several arguments suggest that minimal change nephrotic syndrome (MCNS) results from yet unknown systemic disorder of T cell function. By screening a cDNA…”
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Transcriptional and post-transcriptional alterations of IκBα in active minimal-change nephrotic syndrome by SAHALI, Djillali, PAWLAK, André, LE GOUVELLO, Sabine, LANG, Philippe, VALANCIUTE, Asta, REMY, Philippe, LOIRAT, Chantal, NIAUDET, Patrick, BENSMAN, Albert, GUELLAEN, Georges

“…Minimal-change nephrotic syndrome (MCNS) is a renal disease characterized by heavy glomerular proteinuria and increased production of cytokines by immune…”
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Phototherapeutic Induction of Immunogenic Cell Death and CD8+ T Cell-Granzyme B Mediated Cytolysis in Human Lung Cancer Cells and Organoids by Valančiūtė, Asta, Mathieson, Layla, O'Connor, Richard A, Scott, Jamie I, Vendrell, Marc, Dorward, David A, Akram, Ahsan R, Dhaliwal, Kevin

“…Augmenting T cell mediated tumor killing via immunogenic cancer cell death (ICD) is the cornerstone of emerging immunotherapeutic approaches. We investigated…”
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Potential Role of Soluble ST2 Protein in Idiopathic Nephrotic Syndrome Recurrence Following Kidney Transplantation by Bruneau, Sarah, Le Berre, Ludmilla, PhD, Hervé, Caroline, PhD, Valanciuté, Asta, PhD, Kamal, Maud, PhD, Naulet, Jeanne, Tesson, Laurent, Foucher, Yohann, PhD, Soulillou, Jean-Paul, MD, Sahali, Djillali, MD, PhD, Dantal, Jacques, MD, PhD

“…Background Corticosteroid-resistant idiopathic nephrotic syndrome (INS) recurs rapidly after transplantation in 30% to 50% of transplant recipients, suggesting…”
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C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase by Kamal, Maud, Pawlak, Andre, BenMohamed, Fatima, Valanciuté, Asta, Dahan, Karine, Candelier, Marina, Lang, Philippe, Guellaën, Georges, Sahali, Djillali

“…In naive T cells, Lck exerts a negative control on the ERK/MAPK pathway. We show that c-mip (c-maf inducing protein) interacts with the p85 subunit of PI3…”
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Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19 by Russell, Clark D, Valanciute, Asta, Gachanja, Naomi N, Stephen, Jillian, Penrice-Randal, Rebekah, Armstrong, Stuart D, Clohisey, Sara, Wang, Bo, Al Qsous, Wael, Wallace, William A, Oniscu, Gabriel C, Stevens, Jo, Harrison, David J, Dhaliwal, Kevin, Hiscox, Julian A, Baillie, J Kenneth, Akram, Ahsan R, Dorward, David A, Lucas, Christopher D

“…Immunopathology occurs in the lung and spleen in fatal coronavirus disease (COVID-19), involving monocytes/macrophages and plasma cells. Antiinflammatory…”
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An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE) by Gaughan, Erin E, Quinn, Tom M, Mills, Andrew, Bruce, Annya M, Antonelli, Jean, MacKinnon, Alison C, Aslanis, Vassilios, Li, Feng, O'Connor, Richard, Boz, Cecilia, Mills, Ross, Emanuel, Philip, Burgess, Matthew, Rinaldi, Giulia, Valanciute, Asta, Mills, Bethany, Scholefield, Emma, Hardisty, Gareth, Findlay, Emily Gwyer, Parker, Richard A, Norrie, John, Dear, James W, Akram, Ahsan R, Koch, Oliver, Templeton, Kate, Dockrell, David H, Walsh, Timothy S, Partridge, Stephen, Humphries, Duncan, Wang-Jairaj, Jie, Slack, Robert J, Schambye, Hans, Phung, De, Gravelle, Lise, Lindmark, Bertil, Shankar-Hari, Manu, Hirani, Nikhil, Sethi, Tariq, Dhaliwal, Kevin

“…High circulating galectin-3 is associated with poor outcomes in patients with coronavirus disease (COVID-19). We hypothesized that GB0139, a potent inhaled…”
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Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics by Quinn, Tom M., Gaughan, Erin E., Bruce, Annya, Antonelli, Jean, O'Connor, Richard, Li, Feng, McNamara, Sarah, Koch, Oliver, MacKintosh, Claire, Dockrell, David, Walsh, Timothy, Blyth, Kevin G., Church, Colin, Schwarze, Jürgen, Boz, Cecilia, Valanciute, Asta, Burgess, Matthew, Emanuel, Philip, Mills, Bethany, Rinaldi, Giulia, Hardisty, Gareth, Mills, Ross, Findlay, Emily Gwyer, Jabbal, Sunny, Duncan, Andrew, Plant, Sinéad, Marshall, Adam D.L., Young, Irene, Russell, Kay, Scholefield, Emma, Nimmo, Alastair F., Nazarov, Islom B., Churchill, Grant C., McCullagh, James S.O., Ebrahimi, Kourosh H., Ferrett, Colin, Templeton, Kate, Rannard, Steve, Owen, Andrew, Moore, Anne, Finlayson, Keith, Shankar-Hari, Manu, Norrie, John, Parker, Richard A., Akram, Ahsan R., Anthony, Daniel C., Dear, James W., Hirani, Nik, Dhaliwal, Kevin

“…Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials in COVID19 without characterisation of Pharmacokinetics /Pharmacodynamics including…”
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Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1 by Dunbar, Karen, Valanciute, Asta, Lima, Ana Cristina Silva, Vinuela, Paz Freile, Jamieson, Thomas, Rajasekaran, Vidya, Blackmur, James, Ochocka-Fox, Anna-Maria, Guazzelli, Alice, Cammareri, Patrizia, Arends, Mark J., Sansom, Owen J., Myant, Kevin B., Farrington, Susan M., Dunlop, Malcolm G., Din, Farhat V.N.

“…Aspirin reduces colorectal cancer (CRC) incidence and mortality. Understanding the biology responsible for this protective effect is key to developing…”
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NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome by Valanciuté, Asta, le Gouvello, Sabine, Solhonne, Brigitte, Pawlak, André, Grimbert, Philippe, Lyonnet, Luc, Hue, Sophie, Lang, Philippe, Remy, Philippe, Salomon, Rémy, Bensman, Albert, Guellaën, Georges, Sahali, Djillali

“…Mechanisms underlying the pathophysiology of minimal change nephrotic syndrome (MCNS), the most frequent of glomerular diseases in children, remain elusive,…”
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C-mip interacts physically with RelA and inhibits nuclear factor kappa B activity by Kamal, Maud, Valanciute, Asta, Dahan, Karine, Ory, Virginie, Pawlak, Andre, Lang, P., Guellaen, Georges, Sahali, Djillali

“…The fine regulation of NF-κB activity is crucial for both resting and stimulated cells and relies on complex balance between multiple activators and…”
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The Filamin-A is a partner of Tc-mip, a new adapter protein involved in c-maf-dependent Th2 signaling pathway by Grimbert, Philippe, Valanciute, Asta, Audard, Vincent, Lang, Philippe, Guellaën, Georges, Sahali, Djillali

“…Using a yeast two-hybrid screen, we identified Filamin-A as a binding partner of the new adapter protein c-mip (c-maf inducing protein) and it’s splice variant…”
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Abnormal RNA processing and altered expression of serin-rich proteins in minimal-change nephrotic syndrome by GRIMBERT, Philippe, AUDARD, Vincent, VALANCIUTE, Asta, PAWLAK, André, LANG, Philippe, GUELLAËN, Georges, SAHALI, Djillali

“…Mechanisms underlying the pathophysiology of minimal-change nephrotic syndrome (MCNS), the most frequent glomerular disease in children, remain elusive, but…”
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NF-{kappa}B p65 Antagonizes IL-4 Induction by c-maf in Minimal Change Nephrotic Syndrome by Valanciute, Asta, le Gouvello, Sabine, Solhonne, Brigitte, Pawlak, Andre, Grimbert, Philippe, Lyonnet, Luc, Hue, Sophie, Lang, Philippe, Remy, Philippe, Salomon, Remy, Bensman, Albert, Guellaen, Georges, Sahali, Djillali

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Transcriptional and post-transcriptional alterations of IkappaBalpha in active minimal-change nephrotic syndrome by Sahali, Djillali, Pawlak, André, Gouvello, Sabine LE, Lang, Philippe, Valanciuté, Asta, Remy, Philippe, Loirat, Chantal, Niaudet, Patrick, Bensman, Albert, Guellaen, Georges

“…Minimal-change nephrotic syndrome (MCNS) is a renal disease characterized by heavy glomerular proteinuria and increased production of cytokines by immune…”
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