Search Results - "Valančiūtė, Angelija"
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The Comparative Experimental Study of Sodium and Magnesium Dichloroacetate Effects on Pediatric PBT24 and SF8628 Cell Glioblastoma Tumors Using a Chicken Embryo Chorioallantoic Membrane Model and on Cells In Vitro
Published in International journal of molecular sciences (09-09-2022)“…In this study, pyruvate dehydrogenase kinase-1 inhibition with dichloroacetate (DCA) was explored as an alternative cancer therapy. The study’s aim was to…”
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The Different Temozolomide Effects on Tumorigenesis Mechanisms of Pediatric Glioblastoma PBT24 and SF8628 Cell Tumor in CAM Model and on Cells In Vitro
Published in International journal of molecular sciences (11-02-2022)“…It is necessary to elucidate the individual effects of temozolomide (TMZ) on carcinogenesis and tumor resistance to chemotherapy mechanisms. The study aimed to…”
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Tumors derived from lung cancer cells respond differently to treatment with sodium valproate (a HDAC inhibitor) in a chicken embryo chorioallantoic membrane model
Published in Histology and histopathology (01-12-2022)“…Lung cancer is the most frequent cause of cancer death. Some human lung malignant tumors have a combined small-cell lung cancer (SCLC) and non-small-cell lung…”
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The Anti-Tumorigenic Activity of Sema3C in the Chick Embryo Chorioallantoic Membrane Model
Published in International journal of molecular sciences (12-11-2019)“…Sema3C protein, a member of the class 3 family of secreted semaphorins, play an important role in tumor development by regulating cell proliferation,…”
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The effect of valproic acid on SLC5A8 expression in gonad-intact and gonadectomized rat thymocytes
Published in International journal of immunopathology and pharmacology (01-01-2022)“…Background Valproic acid (VPA) pharmacological mechanisms are related to the anti-inflammatory and anti-viral effects. VPA is a histone deacetylases inhibitor…”
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The Effectiveness of Dichloroacetate on Human Glioblastoma Xenograft Growth Depends on Na+ and Mg2+ Cations
Published in Dose-response (01-01-2021)“…The study’s aim was to investigate the effectiveness of sodium dichloroacetate (NaDCA) or magnesium dichloroacetate (MgDCA) on adult U87 MG and pediatric PBT24…”
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Differential Impact of Valproic Acid on SLC5A8 , SLC12A2 , SLC12A5 , CDH1 , and CDH2 Expression in Adult Glioblastoma Cells
Published in Biomedicines (25-06-2024)“…Valproic acid (VPA) has anticancer, anti-inflammatory, and epigenetic effects. The study aimed to determine the expression of carcinogenesis-related , , , and…”
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Gender-Related Effect of Sodium Dichloroacetate on the Number of Hassall’s Corpuscles and RNA NKCC1 Expression in Rat Thymus
Published in BioMed research international (01-01-2019)“…The aim was to investigate the effect of dichloroacetate (DCA) on thymus weight, Hassall’s corpuscle number (HCs), and NKCC1 RNA expression in Wistar rats aged…”
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Effect of Laryngeal Squamous Cell Carcinoma Tissue Implantation on the Chick Embryo Chorioallantoic Membrane: Morphometric Measurements and Vascularity
Published in BioMed research international (01-01-2015)“…Background. The aim of this study was to develop chick embryo chorioallantoic membrane (CAM) model of laryngeal squamous cell carcinoma (LSCC) and to evaluate…”
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The Effect of Sodium Valproate on the Glioblastoma U87 Cell Line Tumor Development on the Chicken Embryo Chorioallantoic Membrane and on EZH2 and p53 Expression
Published in BioMed research international (01-01-2017)“…Literature data support evidences that glioblastoma (GBM) patients experience prolonged survival due to sodium valproate (NaVP) treatment. The study assessed…”
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Sodium Valproate Inhibits Small Cell Lung Cancer Tumor Growth on the Chicken Embryo Chorioallantoic Membrane and Reduces the p53 and EZH2 Expression
Published in Dose-response (01-04-2018)“…The study aims to test the effect of different sodium valproate (NaVP) doses on small cell lung cancer NCI-H146 cells tumor in chicken embryo chorioallantoic…”
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The Importance of Gender-Related Anticancer Research on Mitochondrial Regulator Sodium Dichloroacetate in Preclinical Studies In Vivo
Published in Cancers (20-08-2019)“…Sodium dichloroacetate (DCA) is an investigational medicinal product which has a potential anticancer preparation as a metabolic regulator in cancer cells'…”
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Valproic Acid Inhibits NA-K-2CL Cotransporter RNA Expression in Male But Not in Female Rat Thymocytes
Published in Dose-response (01-04-2019)“…Objective: The NKCC1 is a recognized tumorigenesis marker as it is important for tumor cell proliferation, differentiation, apoptosis, and tumor progression…”
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SARS-CoV-2 Infection, Sex-Related Differences, and a Possible Personalized Treatment Approach with Valproic Acid: A Review
Published in Biomedicines (21-04-2022)“…Sex differences identified in the COVID-19 pandemic are necessary to study. It is essential to investigate the efficacy of the drugs in clinical trials for the…”
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Sodium valproate effect on the structure of rat glandule thymus: Gender-related differences
Published in Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie (01-07-2015)“…Sodium valproate (VPA) was shown to inhibit cell growth mechanisms such as cell cycle arrest, proliferation suppression, increase of apoptosis. Many aspects of…”
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Different Effects of Valproic Acid on SLC12A2 , SLC12A5 and SLC5A8 Gene Expression in Pediatric Glioblastoma Cells as an Approach to Personalised Therapy
Published in Biomedicines (22-04-2022)“…Valproic acid (VPA) is a histone deacetylase inhibitor with sex-specific immunomodulatory and anticancer effects. This study aimed to investigate the effect of…”
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Sodium Dichloroacetate Pharmacological Effect as Related to Na–K–2Cl Cotransporter Inhibition in Rats
Published in Dose-response (01-10-2018)“…The study objective was to investigate a possible sodium dichloroacetate (DCA) pharmacological mechanism causing an increase in diuresis in rats. The aim was…”
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Sex-related differences of urethane and sodium valproate effects on Ki-67 expression in urethane-induced lung tumors of mice
Published in Experimental and therapeutic medicine (01-06-2017)“…The aim of the present study was to evaluate sex differences in tumorigenesis by assessing the number of Ki-67-positive cells [Ki-67(+)] in urethane-induced…”
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The effect of dichloroacetate on male rat thymus and on thymocyte cell cycle
Published in International journal of immunopathology and pharmacology (01-12-2016)“…The study aim was to investigate the effect of dichloroacetate (DCA) on thymus and the thymocyte cycle in rats. Wistar male gonad-intact and castrated rats…”
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Histology of human glioblastoma transplanted on chicken chorioallantoic membrane
Published in Medicina (Kaunas, Lithuania) (01-01-2009)“…Glioblastoma is the most malignant tumor in the range of cerebral astrocytic gliomas. A lot of experimental models are used to evaluate various properties of…”
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