Search Results - "Vala, Milada"

Circulating clonotypic B cells in classic Hodgkin lymphoma by Jones, Richard J., Gocke, Christopher D., Kasamon, Yvette L., Miller, Carole B., Perkins, Brandy, Barber, James P., Vala, Milada S., Gerber, Jonathan M., Gellert, Lan L., Siedner, Mark, Lemas, M. Victor, Brennan, Sarah, Ambinder, Richard F., Matsui, William

“…Although Hodgkin and Reed-Sternberg (HRS) cells are B lymphoid cells, they are unlike any normal cells of that lineage. Moreover, the limited proliferative…”
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Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations by Gerber, Jonathan M, Gucwa, Jessica L, Esopi, David, Gurel, Meltem, Haffner, Michael C, Vala, Milada, Nelson, William G, Jones, Richard J, Yegnasubramanian, Srinivasan

“…The persistence leukemia stem cells (LSCs) in chronic myeloid leukemia (CML) despite tyrosine kinase inhibition (TKI) may explain relapse after TKI withdrawal…”
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Characterization of chronic myeloid leukemia stem cells by Gerber, Jonathan M., Qin, Lu, Kowalski, Jeanne, Smith, B. Douglas, Griffin, Constance A., Vala, Milada S., Collector, Michael I., Perkins, Brandy, Zahurak, Marianna, Matsui, William, Gocke, Christopher D., Sharkis, Saul J., Levitsky, Hyam I., Jones, Richard J.

“…Although tyrosine kinase inhibitors have redefined the care of chronic myeloid leukemia (CML), these agents have not proved curative, likely due to resistance…”
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Effects of imatinib and interferon on primitive chronic myeloid leukaemia progenitors by Angstreich, Greg R., Matsui, William, Huff, Carol Ann, Vala, Milada S., Barber, James, Hawkins, Anita L., Griffin, Constance A., Douglas Smith, B., Jones, Richard J.

“…Summary Imatinib has impressive activity against chronic myeloid leukaemia (CML), but does not appear to completely eradicate the disease. Although responses…”
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A clinically relevant population of leukemic CD34+CD38− cells in acute myeloid leukemia by Gerber, Jonathan M., Smith, B. Douglas, Ngwang, Brownhilda, Zhang, Hao, Vala, Milada S., Morsberger, Laura, Galkin, Steven, Collector, Michael I., Perkins, Brandy, Levis, Mark J., Griffin, Constance A., Sharkis, Saul J., Borowitz, Michael J., Karp, Judith E., Jones, Richard J.

“…Relapse of acute myeloid leukemia (AML) is thought to reflect the failure of current therapies to adequately target leukemia stem cells (LSCs), the rare,…”
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Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria by Brodsky, R A, Vala, M S, Barber, J P, Medof, M E, Jones, R J

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder resulting from mutations in an X-linked gene, PIG-A , that encodes an…”
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Inhibited apoptosis and drug resistance in acute myeloid leukaemia by Smith, B. Douglas, Bambach, Barbara J., Vala, Milada S., Barber, James P., Enger, Cheryl, Brodsky, Robert A., Burke, Philip J., Gore, Steven D., Jones, Richard J.

“…Despite extensive investigation into mechanisms of drug resistance in acute myeloid leukaemia (AML), the aetiology of therapeutic resistance is unclear. We…”
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Autologous bone marrow transplantation with 4‐hydroperoxycyclophosphamide purging for acute myeloid leukaemia beyond first remission: a 10‐year experience by Smith, B. Douglas, Jones, Richard J., Lee, Shing M., Piantadosi, Steve, Vala, Milada S., Fuller, Don, Gore, Steven D., Noga, Steven J., O'Donnell, Paul V., Braine, Hayden, Vogelsang, Georgia B., Fuchs, Ephraim J., Flinn, Ian W., Brodsky, Robert A., Ambinder, Richard F., Miller, Carole B.

“…Between January 1987 and January 1997, 69 eligible patients with acute myeloid leukaemia (AML) in either second (CR2) or third (CR3) complete remission (CR2 =…”
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Growth factor-mediated terminal differentiation of chronic myeloid leukemia by BEDI, A, GRIFFIN, C. A, BARBER, J. P, VALA, M. S, HAWKINS, A. L, SHARKIS, S. J, ZEHNBAUER, B. A, JONES, R. J

“…Expression of the BCR-ABL chimeric gene in chronic myeloid leukemia results in the inhibition of apoptosis, a genetically programmed process of autonomous cell…”
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The Clinical Relevance of Acute Myeloid Leukemia Stem Cells by Gerber, Jonathan M., Smith, B. Douglas, Ngwang, Brownhilda, Zhang, Hao, Vala, Milada, Morsberger, Laura, Galkin, Steven, Collector, Michael, Perkins, Brandy, Levis, Mark J., Griffin, Constance, Sharkis, Saul J., Borowitz, Michael J., Karp, Judith E., Jones, Richard J.

“…Abstract 240▪▪This icon denotes a clinically relevant abstract Relapse of acute myeloid leukemia (AML) is hypothesized to reflect the failure of current…”
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Differentiation therapy in poor risk myeloid malignancies: Results of a dose finding study of the combination bryostatin-1 and GM-CSF by Smith, B. Douglas, Jones, Richard J, Cho, Eunpi, Kowalski, Jeanne, Karp, Judith E, Gore, Steven D, Vala, Milada, Meade, Brooke, Baker, Sharyn D, Zhao, Ming, Piantadosi, Steven, Zhang, Zhe, Blumenthal, Gideon, Warlick, Erica D, Brodsky, Robert A, Murgo, Anthony, Rudek, Michelle A, Matsui, William H

“…Abstract Purpose Pharmacologic differentiating agents have had relatively limited clinical success outside of the use of ATRA in acute promyelocytic leukemia…”
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BCR-ABL-Mediated Inhibition of Apoptosis With Delay of G2/M Transition After DNA Damage: A Mechanism of Resistance to Multiple Anticancer Agents by Bedi, Atul, Barber, James P., Bedi, Gauri C., El-Deiry, Wafik S., Sidransky, David, Vaia, Milada S., Akhtar, Adil J., Hilton, John, Jones, Richard J.

“…A critical determinant of the efficacy of antineoplastic therapy is the response of malignant cells to DNA damage induced by anticancer agents. The p53…”
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Anti-Leukemic Effect of Maintenance Chemotherapy Is Mediated by Induction of Differentiation by Lin, Tara L., Matsui, William, Vala, Milada S., Brennan, Sarah, Smith, B. Douglas, Jones, Richard J.

“…The clinical benefit of maintenance therapy (prolonged post-remission low-dose therapy) has been limited to two diseases, acute lymphocytic leukemia (ALL) and…”
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Assessment of Aldehyde Dehydrogenase in Viable Cells by Jones, Richard J., Barber, James P., Vala, Milada S., Collector, Michael I., Kaufmann, Scott H., Ludeman, Susan M., Colvin, O.Michael, Hilton, John

“…Cytosolic aldehyde dehydrogenase (ALDH), an enzyme responsible for oxidizing intracellular aldehydes, has an important role in ethanol, vitamin A, and…”
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Anti‐tumour activity of interferon‐alpha in multiple myeloma: role of interleukin 6 and tumor cell differentiation by Matsui, William, Huff, Carol Ann, Vala, Milada, Barber, James, Smith, B. Douglas, Jones, Richard J.

“…Interferon‐alpha (IFN‐α) is a pleotropic cytokine that has clinical activity against a wide variety of malignancies, including multiple myeloma (MM). In vitro,…”
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The role of growth factors in the activity of pharmacological differentiation agents by MATSUI, William H, GLADSTONE, Douglas E, VALA, Milada S, BARBER, James P, BRODSKY, Robert A, SMITH, B. Douglas, JONES, Richard J

“…Bryostatin-1 inhibits acute myeloid leukemia (AML) in vitroat doses that stimulate the growth of normal hematopoietic progenitors.Although bryostatin-1 has a…”
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Cancer Stem Cell Targeting in Multiple Myeloma by GRN163L, a Novel and Potent Telomerase Inhibitor by Matsui, William, Wang, Qiuju, Vala, Milada, Barber, James P., Meeker, Alan, Tressler, Robert, Harley, Calvin, Huff, Carol A., Smith, B. Douglas, Jones, Richard J.

“…Telomerase activity (TA) is required within normal cells capable of long-term replication, including stem cells and is upregulated in many cancers. In the…”
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Requirement for myeloid growth factors in the differentiation of acute promyelocytic leukaemia by Matsui, William, Douglas Smith, B., Vala, Milada, Beal, Nikeshia, Huff, Carol Ann, Diehl, Louis F., Jones, Richard J.

“…Summary It is well known that the differentiation of acute promyelocytic leukaemia (APL) cells by all‐trans‐retinoic acid (ATRA) may be enhanced by myeloid…”
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Characterization of Mouse Lymphohematopoietic Stem Cells Lacking Spleen Colony-Forming Activity by Jones, Richard J., Collector, Michael I., Barber, James P., Vala, Milada S., Fackler, Mary J., May, W. Stratford, Griffin, Constance A., Hawkins, Anita L., Zehnbauer, Barbara A., Hilton, John, Colvin, O. Michael, Sharkis, Saul J.

“…The classical definition of lymphohematopoietic stem cells (LHSC), the most primitive progenitors of all blood cells, requires that they have the capacity for…”
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Differentiation Therapy for Poor Risk Myeloid Malignancies: Results of a Dose Finding Study of Bryostatin-1 (BRYO) + GM-CSF by Smith, B. Douglas, Matsui, William H., Gladstone, Douglas E., Karp, Judith E., Gore, Steven D., Huff, Carol Ann, Vala, Milada, Baker, Sharyn, Zhao, Ming, Piantadosi, Steven, Jones, Richard J.

“…Clinically effective differentiating therapy has been limited to the use of all-trans-retinoic acid in patients (pts) with acute promyelocytic leukemia. We…”
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